$409 Cheap American Airlines flights Houston (HOU) to Knoxville (TYS)

View $409 flight on Fri, Dec 19, 2025Opens in a new window

$409 Cheap American Airlines flights Houston (HOU) to Knoxville (TYS)

Prices were available within the past 7 days and start at $409 for one-way flights and $619 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Fri, Dec 19 - Sat, Dec 20
HOU
Houston
TYS
Knoxville
$619 Roundtrip, found 3 hours ago
$619
Roundtrip
found 3 hours ago
Select American Airlines flight, departing Fri, Dec 19 from Houston to Knoxville, returning Sat, Dec 20, priced at $619 found 3 hours ago
American Airlines
Fri, Dec 19 - Sat, Dec 20
HOU
Houston
TYS
Knoxville
$659 Roundtrip, found 3 hours ago
$659
Roundtrip
found 3 hours ago
Select American Airlines flight, departing Fri, Dec 19 from Houston to Knoxville, returning Sat, Dec 20, priced at $659 found 3 hours ago
American Airlines
Fri, Dec 19 - Sat, Dec 20
HOU
Houston
TYS
Knoxville
$669 Roundtrip, found 3 hours ago
$669
Roundtrip
found 3 hours ago
Select American Airlines flight, departing Fri, Dec 19 from Houston to Knoxville, returning Sat, Dec 20, priced at $669 found 3 hours ago
American Airlines
Fri, Dec 19 - Sat, Dec 20
HOU
Houston
TYS
Knoxville
$674 Roundtrip, found 3 hours ago
$674
Roundtrip
found 3 hours ago
Select American Airlines flight, departing Fri, Dec 19 from Houston to Knoxville, returning Sat, Dec 20, priced at $674 found 3 hours ago
American Airlines
Fri, Dec 19 - Sat, Dec 20
HOU
Houston
TYS
Knoxville
$709 Roundtrip, found 3 hours ago
$709
Roundtrip
found 3 hours ago
Select American Airlines flight, departing Fri, Dec 19 from Houston to Knoxville, returning Sat, Dec 20, priced at $709 found 3 hours ago
American Airlines
Fri, Dec 19 - Sat, Dec 20
HOU
Houston
TYS
Knoxville
$714 Roundtrip, found 3 hours ago
$714
Roundtrip
found 3 hours ago
Select American Airlines flight, departing Fri, Dec 19 from Houston to Knoxville, returning Sat, Dec 20, priced at $714 found 3 hours ago
American Airlines
Fri, Dec 19 - Sat, Dec 20
HOU
Houston
TYS
Knoxville
$733 Roundtrip, found 3 hours ago
$733
Roundtrip
found 3 hours ago
Select American Airlines flight, departing Fri, Dec 19 from Houston to Knoxville, returning Sat, Dec 20, priced at $733 found 3 hours ago
American Airlines
Fri, Dec 19 - Sat, Dec 20
HOU
Houston
TYS
Knoxville
$749 Roundtrip, found 3 hours ago
$749
Roundtrip
found 3 hours ago
Select American Airlines flight, departing Fri, Dec 19 from Houston to Knoxville, returning Sat, Dec 20, priced at $749 found 3 hours ago
American Airlines
Fri, Dec 19 - Sat, Dec 20
HOU
Houston
TYS
Knoxville
$749 Roundtrip, found 3 hours ago
$749
Roundtrip
found 3 hours ago
Select American Airlines flight, departing Fri, Dec 19 from Houston to Knoxville, returning Sat, Dec 20, priced at $749 found 3 hours ago

Find the cheapest month to fly from Houston (HOU) to Knoxville (TYS)

November is typically the cheapest month to fly

From $188 - $477 per traveler.

Alternative airports near Knoxville

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to McGhee Tyson TYS. Cheapest and Closest option available. Average driving time to city center is 22 minutes. Flights from $479
TYS
McGhee Tyson
CheapestClosest
Average driving time to city center22 min
Flights from $479
Flights from Houston (HOU) to Knoxville (TYS)
Origin airport
William P. Hobby
Destination airport
McGhee Tyson
Airlines serving
American Airlines, Delta
Popular airline
American Airlines
Distance
1249 km
Average flight time
3 hours 1 min