$409 Cheap American Airlines flights Houston (HOU) to Knoxville (TYS)

View $409 flight on Fri, Dec 19, 2025Opens in a new window

$409 Cheap American Airlines flights Houston (HOU) to Knoxville (TYS)

Prices were available within the past 7 days and start at $409 for one-way flights and $579 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Fri, Dec 19 - Sat, Dec 20
HOU
Houston
TYS
Knoxville
$579 Roundtrip, found 22 hours ago
$579
Roundtrip
found 22 hours ago
Select American Airlines flight, departing Fri, Dec 19 from Houston to Knoxville, returning Sat, Dec 20, priced at $579 found 22 hours ago
American Airlines
Fri, Dec 19 - Sat, Dec 20
HOU
Houston
TYS
Knoxville
$619 Roundtrip, found 22 hours ago
$619
Roundtrip
found 22 hours ago
Select American Airlines flight, departing Fri, Dec 19 from Houston to Knoxville, returning Sat, Dec 20, priced at $619 found 22 hours ago
American Airlines
Fri, Dec 19 - Sat, Dec 20
HOU
Houston
TYS
Knoxville
$629 Roundtrip, found 22 hours ago
$629
Roundtrip
found 22 hours ago
Select American Airlines flight, departing Fri, Dec 19 from Houston to Knoxville, returning Sat, Dec 20, priced at $629 found 22 hours ago
American Airlines
Fri, Dec 19 - Sat, Dec 20
HOU
Houston
TYS
Knoxville
$669 Roundtrip, found 22 hours ago
$669
Roundtrip
found 22 hours ago
Select American Airlines flight, departing Fri, Dec 19 from Houston to Knoxville, returning Sat, Dec 20, priced at $669 found 22 hours ago
American Airlines
Fri, Dec 19 - Sat, Dec 20
HOU
Houston
TYS
Knoxville
$693 Roundtrip, found 22 hours ago
$693
Roundtrip
found 22 hours ago
Select American Airlines flight, departing Fri, Dec 19 from Houston to Knoxville, returning Sat, Dec 20, priced at $693 found 22 hours ago
American Airlines
Fri, Dec 19 - Sat, Dec 20
HOU
Houston
TYS
Knoxville
$709 Roundtrip, found 22 hours ago
$709
Roundtrip
found 22 hours ago
Select American Airlines flight, departing Fri, Dec 19 from Houston to Knoxville, returning Sat, Dec 20, priced at $709 found 22 hours ago
American Airlines
Fri, Dec 19 - Sat, Dec 20
HOU
Houston
TYS
Knoxville
$719 Roundtrip, found 22 hours ago
$719
Roundtrip
found 22 hours ago
Select American Airlines flight, departing Fri, Dec 19 from Houston to Knoxville, returning Sat, Dec 20, priced at $719 found 22 hours ago
American Airlines
Fri, Dec 19 - Sat, Dec 20
HOU
Houston
TYS
Knoxville
$733 Roundtrip, found 22 hours ago
$733
Roundtrip
found 22 hours ago
Select American Airlines flight, departing Fri, Dec 19 from Houston to Knoxville, returning Sat, Dec 20, priced at $733 found 22 hours ago

Find the cheapest month to fly from Houston (HOU) to Knoxville (TYS)

November is typically the cheapest month to fly

From $188 - $477 per traveler.

Alternative airports near Knoxville

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to McGhee Tyson TYS. Cheapest and Closest option available. Average driving time to city center is 22 minutes. Flights from $479
TYS
McGhee Tyson
CheapestClosest
Average driving time to city center22 min
Flights from $479
Flights from Houston (HOU) to Knoxville (TYS)
Origin airport
William P. Hobby
Destination airport
McGhee Tyson
Airlines serving
American Airlines, Delta
Popular airline
Delta
Distance
1249 km
Average flight time
3 hours 1 min