Southeast Missouri Vacation Packages for 2025
Build a Flight + Hotel Bundle & Save up to $536 On Your Vacation*
Southeast Missouri Flight + Hotel packages
Price found within the past 48 hours. Click for updated prices.
Hilton Garden Inn Chesterfield
Price was $811, price is now $601 per person
$601
per person
Nov 21 - Nov 26
found 1 hour ago
Roundtrip non-stop flight included
Baltimore (BWI) to St. Louis (STL)
Stay at this 3-star business-friendly hotel in Chesterfield. Enjoy free WiFi, free parking, and breakfast (surcharge). Popular attractions The J - Chesterfield Gym & Fitness Center and Topgolf are located nearby.
The Wildwood Hotel
Save 100% on your flight
Price was $1,078, price is now $620 per person
$620
per person
Nov 21 - Nov 26
found 1 hour ago
Roundtrip non-stop flight included
Baltimore (BWI) to St. Louis (STL)
Stay at this 3.5-star business-friendly hotel in Wildwood. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the convenient parking in our reviews. Popular attractions Six Flags St. Louis and Skid Row are located nearby.
Angad Arts Hotel St. Louis, Tapestry Collection by Hilton
Grand Center
Price was $928, price is now $685 per person
$685
per person
Nov 21 - Nov 26
found 1 hour ago
Roundtrip non-stop flight included
Baltimore (BWI) to St. Louis (STL)
Stay at this 4-star business-friendly hotel in St. Louis. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the bar and the helpful staff in our reviews. Popular attractions St. Louis Union Station and Busch Stadium are located nearby.
Ameristar Casino Resort and Spa
Price was $1,107, price is now $833 per person
$833
per person
Nov 21 - Nov 26
found 1 hour ago
Roundtrip non-stop flight included
Baltimore (BWI) to St. Louis (STL)
Stay at this 4.5-star luxury hotel in St. Charles. Enjoy an outdoor pool, a full-service spa, and 6 restaurants. Our guests praise the clean rooms and the property condition in our reviews. Popular attractions Ameristar Casino St. Charles and Hollywood Casino Amphitheatre are located nearby.
Hampton Inn By Hilton St Louis Airport
Woodson Terrace
Price was $829, price is now $629 per person
$629
per person
Nov 21 - Nov 26
found 1 hour ago
Roundtrip non-stop flight included
Baltimore (BWI) to St. Louis (STL)
Stay at this hotel in St. Louis. Enjoy free breakfast, free WiFi, and a free airport shuttle. Popular attractions Hollywood Casino Amphitheatre and Payne-Gentry Historical House are located nearby.
Hilton Garden Inn St. Louis/O'Fallon MO
Price was $868, price is now $660 per person
$660
per person
Nov 21 - Nov 26
found 1 hour ago
Roundtrip non-stop flight included
Baltimore (BWI) to St. Louis (STL)
Stay at this 3-star hotel in O'Fallon. Enjoy free WiFi, free parking, and breakfast (surcharge). Popular attractions 9-11 Memorial and August A. Busch Memorial Conservation Area are located nearby.
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See all available trips from Columbus to Southeast Missouri
View all tripsSoutheast Missouri Vacation Packages
Looking for ways save money and time on your next holiday to Southeast Missouri? Don't worry, as AARP Travel Center Powered by Expedia® is here to help. We can assist you with hotel bookings, flights, car rentals and more. You can get almost everything you need here to make your trip to Southeast Missouri incredible. In only a few clicks, you can choose the best Southeast Missouri vacation package for you and your family. AARP Travel Center has a fabulous choice of accommodations and flight, and Southeast Missouri activities to pull from.
Hotel Deals in Southeast Missouri
You can choose from around 604 hotels. Whether you want to stay in the heart of the city or pick a spot that is near all the Southeast Missouri hot spots, we have plenty of options available.
We have competitive rates on everything from luxury hotels that check off all the vacation must-haves to affordable hotels perfect for those on looking to save. You can browse all the options and choose the accommodation that is best for you. With AARP Travel Center's Southeast Missouri hotel packages, you not only get a great rate on your flight, but also a great place to stay.
Things to do in Southeast Missouri
People from all over make this city their vacation destination, and with good reason. A little curiosity and asking the right people, like your hotel's concierge, goes a long way into having a unique experience.
You can also check out our "Things to Do" tab for more inspiration or to book an activity in Southeast Missouri.
Package Your Southeast Missouri Vacation and Save
As an AARP Member, you get to cash in on all the great savings. You can save on select hotels worldwide, flights, and also car rentals. No matter what vacation package you select, you can rest easy knowing that you already saved on your trip. So what are you waiting for? Book now and get ready for your Southeast Missouri vacation.
Top Hotel Deals
Baymont Inn and Suites by Wyndham Farmington, MO
1625 W Columbia St, Farmington, MO
61.18 km from city center
Book a stay at this business-friendly hotel in Farmington. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the breakfast and the helpful ...
Drury Plaza Hotel Cape Girardeau Conference Center
3351 Percy Drive, Cape Girardeau, MO
75.5 km from city center
Stay at this 3-star business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
The Riverview
777 Main St, Cape Girardeau, MO
81.09 km from city center
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free WiFi, free parking, and 2 restaurants. Popular attractions Isle Casino Cape Girardeau ...
The Farmstead Hotel
778 E 3rd St, Caruthersville, MO
134.14 km from city center
Stay at this hotel in Caruthersville. Enjoy free WiFi, free parking, and a casino. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
Pear Tree Inn Cape Girardeau Near the Medical Center
3248 William St, Cape Girardeau, MO
75.8 km from city center
Stay at this hotel in Cape Girardeau. Enjoy free WiFi, a 24-hour front desk, and daily housekeeping. Our guests praise the helpful staff and the clean rooms ...
Pear Tree Inn Cape Girardeau West
103 Cape West Pkwy, Cape Girardeau, MO
75.35 km from city center
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
3003 SOUTH OLD ORCHARD ROAD, Jackson, MO
73.6 km from city center
Stay at this 3-star business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
Drury Inn & Suites Sikeston, MO
2608 East Malone Ave, Miner, Sikeston, MO
87.14 km from city center
Stay at this 3-star business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
Motel 6 Poplar Bluff, MO
4101 Highway 67 N, Poplar Bluff, MO
46.95 km from city center
Stay at this motel in Poplar Bluff. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
La Quinta Inn & Suites by Wyndham Festus - St. Louis South
1001 Veterans Blvd, Festus, MO
110.1 km from city center
Stay at this 3-star business-friendly hotel in Festus. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
Comfort Inn Festus - St Louis South
1303 Veterans Blvd, Festus, MO
110.13 km from city center
Book a stay at this business-friendly hotel in Festus. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
Courtyard by Marriott Cape Girardeau Downtown
400 Broadway St., Cape Girardeau, MO
80.52 km from city center
Stay at this 3-star business-friendly hotel in Cape Girardeau. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff ...
Fairfield Inn & Suites by Marriott Poplar Bluff
3109 Oak Grove, Poplar Bluff, MO
48.35 km from city center
Book a stay at this business-friendly hotel in Poplar Bluff. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
Don't see what you're looking for?
See all available properties in Southeast Missouri
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top Flight Deals
These prices were available within the past 7 days. Prices quoted are per person, round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.
Mon, Sep 29 - Mon, Oct 6
EWR
Newark Liberty Intl. Airport
STL
Lambert-St. Louis Intl.
$154 Roundtrip, found 1 hour ago
$154
Roundtrip
found 1 hour ago
Sat, Dec 6 - Tue, Dec 9
JFK
John F. Kennedy Intl.
STL
Lambert-St. Louis Intl.
$159 Roundtrip, found 6 days ago
$159
Roundtrip
found 6 days ago
Sun, Dec 7 - Mon, Dec 8
DEN
Denver Intl.
STL
Lambert-St. Louis Intl.
$197 Roundtrip, found 13 hours ago
$197
Roundtrip
found 13 hours ago
Tue, Sep 30 - Tue, Oct 7
EWR
Newark Liberty Intl. Airport
STL
Lambert-St. Louis Intl.
$224 Roundtrip, found 1 hour ago
$224
Roundtrip
found 1 hour ago
Wed, Oct 1 - Sun, Oct 5
EWR
Newark Liberty Intl. Airport
STL
Lambert-St. Louis Intl.
$245 Roundtrip, found 1 hour ago
$245
Roundtrip
found 1 hour ago