
Santo Domingo Vacations
Build a Flight + Hotel Bundle & Save up to $536 On Your Vacation*
Santo Domingo Flight + Hotel packages
Price found within the past 48 hours. Click for updated prices.

Hotel Riu Plaza Panama
Bella Vista
Price was $1,199, price is now $887 per person
$887
per person
Dec 25 - Dec 30
found 1 day ago
Roundtrip non-stop flight included
Charlotte (CLT) to Panama City (PTY)
Stay at this 5-star luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and 3 restaurants. Our guests praise the breakfast and the pool in our reviews. Popular attractions Albrook Shopping Mall and Via Espana are located nearby.

Central Hotel Panama Casco Viejo
Casco Viejo
Save 100% on your flight
Price was $2,628, price is now $1,516 per person
$1,516
per person
Dec 25 - Dec 30
found 1 day ago
Roundtrip non-stop flight included
Charlotte (CLT) to Panama City (PTY)
Stay at this 4-star spa hotel in Panama City. Enjoy free WiFi, a full-service spa, and 3 restaurants. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.

Dreams Playa Bonita Panama - All Inclusive
Save 100% on your flight
Price was $2,538, price is now $1,872 per person
$1,872
per person
Dec 25 - Dec 30
found 1 day ago
Roundtrip non-stop flight included
Charlotte (CLT) to Panama City (PTY)
Stay at this 4-star beach property in Veracruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the pool and the helpful staff in our reviews. Popular attractions Albrook Shopping Mall and Amador Causeway are located nearby.

Megapolis Hotel Panamá
San Francisco
Price was $1,324, price is now $984 per person
$984
per person
Dec 25 - Dec 30
found 1 day ago
Roundtrip non-stop flight included
Charlotte (CLT) to Panama City (PTY)
Stay at this 4.5-star luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Albrook Shopping Mall and Avenida Balboa are located nearby.

Bristol Panama, a Registry Collection Hotel
Bella Vista
Price was $1,465, price is now $1,106 per person
$1,106
per person
Dec 25 - Dec 30
found 1 day ago
Roundtrip non-stop flight included
Charlotte (CLT) to Panama City (PTY)
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, free valet parking, and a full-service spa. Our guests praise the helpful staff and the property condition in our reviews. Popular attractions Albrook Shopping Mall and Via Espana are located nearby.

MARINN PLACE Financial District
Bella Vista
Price was $1,427, price is now $1,081 per person
$1,081
per person
Dec 25 - Dec 30
found 1 day ago
Roundtrip non-stop flight included
Charlotte (CLT) to Panama City (PTY)
Stay at this 3.5-star business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Albrook Shopping Mall and Via Espana are located nearby.
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Hotel Bambito By Faranda Boutique, a member of Radisson Individuals
Volcan, Via Cerro Punta, Volcan, Chiriqui
33.1 km from city center
Stay at this 3-star family-friendly hotel in Volcan. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Área Silvestre Protegida Lagunas ...

Las Olas Resort
Avenida Don Antonio Anguizola, Playa La Barqueta, Guarumal, Chiriqui
27.23 km from city center
Stay at this 3-star beach resort in Guarumal. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews.

Los Brezos Boutique Hotel
Calle Tercera Norte, Volcan, Chiriquí
33.52 km from city center
Stay at this 3.5-star business-friendly hotel in Volcan. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Área Silvestre Protegida Lagunas ...

Hotel Dos Rios
43, Nueva California, Nueva California
34.81 km from city center
Stay at this 3-star hotel in Nueva California. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Área Silvestre Protegida Lagunas de Volcán ...

Little Italy B&B
Urb. Dona Fela 40, Varital de Boqueron, Tijeras
17.4 km from city center
Stay at this 3-star business-friendly B&B in Tijeras. Enjoy free breakfast, free WiFi, and free parking.

Parque Central
Residencial Parque Central, La Concepción, Chiriqui Province
12.92 km from city center
Stay at this chalet in La Concepción. Enjoy free parking, free airport pick-up, and laundry facilities.

Casa Little Italy
Urbanizacion Dona Fela 40, Tijeras, Chiriqui
17.35 km from city center
Stay at this 3-star vacation home in Tijeras. Enjoy free WiFi, free parking, and an airport shuttle (surcharge).

Hotel Las Canarias
Carretera puerto armuelles, Paso Canoas, Provincia de Chiriquí
11.91 km from city center
Stay at this 3-star hotel in Paso Canoas. Enjoy free WiFi, free parking, and 4 restaurants.

Big Daddy's Beach Club and Hotel
Puerto Armuelles, Puerto Armuelles
29.17 km from city center
Book a stay at this beach hotel in Puerto Armuelles. Enjoy free WiFi, free parking, and a beach locale.

Hostal Victoria Volcán Chiriquí S. A.
Volcan Chiriquí, Calle Estudiante Calle 3era y Calle 4ta, Nueva California, Chiriquí
34.2 km from city center
Stay at this hostal in Nueva California. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Área Silvestre Protegida Lagunas de Volcán ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top Flight Deals
These prices were available within the past 7 days. Prices quoted are per person, round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Tue, Jan 20 - Sun, Jan 25
PTY
Tocumen Intl.
DAV
Enrique Malek Intl.
$128 Roundtrip, found 1 day ago
$128
Roundtrip
found 1 day ago

Tue, Jan 20 - Sun, Jan 25
PTY
Tocumen Intl.
DAV
Enrique Malek Intl.
$138 Roundtrip, found 1 day ago
$138
Roundtrip
found 1 day ago

Tue, Jan 20 - Wed, Jan 21
PTY
Tocumen Intl.
DAV
Enrique Malek Intl.
$144 Roundtrip, found 1 day ago
$144
Roundtrip
found 1 day ago

Tue, Jan 20 - Sun, Jan 25
PTY
Tocumen Intl.
DAV
Enrique Malek Intl.
$150 Roundtrip, found 1 day ago
$150
Roundtrip
found 1 day ago