Santa Isabel Vacations
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Santa Isabel Flight + Hotel packages
Price found within the past 48 hours. Click for updated prices.
Riande Aeropuerto Hotel & Casino
$739
per person
Oct 24 - Oct 28
found 17 hours ago
Roundtrip non-stop flight included
Orlando (MCO) to Panama City (PTY)
Book a stay at this family-friendly resort in Tocumen. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in our reviews. Popular attractions Metromall Panama and Los Pueblos Commercial Center are located nearby.
Good value for money close to the airport, clean room, simple but good breakfast (starting at 6:30 am), nice pool with tropical vibe (open till 10 pm)
Reviewed on Aug 11, 2026
Central Hotel Panama Casco Viejo
Casco Viejo
$793
per person
Oct 24 - Oct 28
found 17 hours ago
Roundtrip non-stop flight included
Orlando (MCO) to Panama City (PTY)
Book a stay at this spa hotel in Panama City. Enjoy free WiFi, a full-service spa, and 3 restaurants. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.
Nice hotel. Great location. Good breakfast. Our only complaint is about noise. The hotel has live music in the atrium from early in the morning until about 10 pm. Our room, along with many others, had windows facing into the atrium, and the noise from the music, and sometimes large tour groups at breakfast, may disturb your sleep.
Reviewed on Aug 10, 2026
Megapolis Hotel Panamá
San Francisco
$874
per person
Oct 24 - Oct 28
found 17 hours ago
Roundtrip non-stop flight included
Orlando (MCO) to Panama City (PTY)
Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Albrook Shopping Mall and Avenida Balboa are located nearby.
Hyatt Regency Panama City
Bella Vista
$819
per person
Oct 24 - Oct 28
found 17 hours ago
Roundtrip non-stop flight included
Orlando (MCO) to Panama City (PTY)
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, free valet parking, and 2 restaurants. Popular attractions Albrook Shopping Mall and Via Espana are located nearby.
Great staff, clean rooms, excellent value
Reviewed on Aug 11, 2026
Hotel Riu Plaza Panama
Bella Vista
$969
per person
Nov 2 - Nov 6
found 1 day ago
Roundtrip non-stop flight included
New York (NYC) to Panama City (PTY)
Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and 3 restaurants. Our guests praise the breakfast and the pool in our reviews. Popular attractions Albrook Shopping Mall and Avenida Balboa are located nearby.
Beautiful hotel. Excelente service. Location is also great but the highlight of our stay was definitely the breakfast. It was delicious and had a great variety of foods. Will definitely stay here again
Reviewed on Aug 12, 2026
Sofitel Legend Casco Viejo, Panama City
Casco Viejo
$1,166
per person
Oct 24 - Oct 28
found 17 hours ago
Roundtrip non-stop flight included
Orlando (MCO) to Panama City (PTY)
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the helpful staff and the property condition in our reviews. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.
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See all available trips from Columbus to Santa Isabel
View all tripsSanta Isabel Vacation Packages
Looking for ways save time and money on your upcoming holiday to Santa Isabel? The AARP Travel Center Powered by Expedia® can help you do both. We can assist you with hotel bookings, flights, car rentals and more. You can get almost everything you need here to make your trip to Santa Isabel incredible. In only a few clicks, you can pick the best vacation package for you. We have a huge choice of flights and lodgings, as well as local activities to pick from.
Santa Isabel Hotels
Our listings include lodgings that are close to all the Santa Isabel points of interest, and others that are just outside the city center for a quieter retreat.
From Santa Isabel hotels with swimming pools and on-site restaurants, to boutique accommodations that add all the thoughtful amenities, you'll get a hotel here that will make your trip astounding. With AARP Travel Center's Santa Isabel hotel packages, you not only get a great rate on your flight, but also a fantastic place to stay.
Things to do in Santa Isabel
You'll discover that Santa Isabel always has something going on. A little curiosity and asking the right people, like your hotel's concierge, goes a long way into having a unique experience.
Looking for more? Then Check out AARP Travel Center's "Things to Do" Page.
Package Your Santa Isabel Vacation and Save
As an AARP Member, you can benefit from all the great deals. You can save on select hotels worldwide, flights, and car rentals. No matter what vacation package you choose, you can rest easy knowing that you already saved on your trip. So what are you waiting for? Book today and get ready for your Santa Isabel vacation.
Top Hotel Deals
Cocoloco - Catamaran Lagoon 52F SAN BLAS
El Porvenir Narganá Guna Yala
Book a stay at this beach cruise ship in San Blas Islands. Enjoy free breakfast, free WiFi, and a beach locale. Popular attractions Porvenir Museum and Isla ...
Private Ocean-Front Cabin with private bathroom on San Blas Island
Diablo Island Narganá Guna Yala
Stay at this hotel in San Blas Islands. Enjoy free breakfast, an airport shuttle (surcharge), and a garden. Popular attractions Isla Diablo and Isla Chichime ...
Private wood Cabins on San Blas island - private bathroom
Wailidup Island Narganá Guna Yala
Stay at this hotel in San Blas Islands. Enjoy free breakfast, a beach locale, and a marina. Popular attractions Isla Chichime and Isla Diablo are located ...
Cabins on paradise San Blas island
9.587566, -78.879820 Narganá San Blas
Stay at this hotel in Narganá. Enjoy free breakfast, an airport shuttle (surcharge), and a snack bar/deli. Popular attraction Museum is located nearby.
Paradise Over the Water Cabins in San Blas
G4V2 48 Narganá Guna Yala
Book a stay at this beach cabin in San Blas Islands. Enjoy free breakfast, a beach locale, and an airport shuttle (surcharge). Popular attractions Porvenir Museum ...
Trips Guna Yala
Urgandi, Mamardub Narganá Guna Yala
Stay at this B&B in Narganá. Enjoy free breakfast, daily housekeeping, and an outdoor pool. Popular attraction Museum is located nearby.
Hotel El Porvenir
Isla Porvenir Narganá Guna Yala
Stay at this hotel in San Blas Islands. Enjoy free breakfast, a beach locale, and a bar/lounge. Popular attractions Porvenir Museum and Isla Chichime are located ...
The Jungle Lodge at Kalu Yala - Glamping
7P47 2M Cerro Azul San Martín Panama
Book a stay at this family-friendly campground in San Martín. Enjoy free WiFi, free parking, and 5 outdoor pools. Popular attraction Honeycreeper Ridge Trail ...
The Camp at Kalu Yala
San Martín San Martín Panama Province
Book a stay at this family-friendly campground in San Martín. Enjoy free parking, 10 outdoor pools, and breakfast (surcharge). Popular attraction Honeycreeper ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top Flight Deals
These prices were available within the past 7 days. Prices quoted are per person, round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.
Thu, Oct 29 - Fri, Oct 30
SJO
Juan Santamaría Intl.
PTY
Tocumen Intl.
$243
Roundtrip
found 17 hours ago
Thu, Oct 29 - Fri, Oct 30
SJO
Juan Santamaría Intl.
PTY
Tocumen Intl.
$268
Roundtrip
found 17 hours ago
Thu, Sep 24 - Tue, Sep 29
MIA
Miami Intl.
PTY
Tocumen Intl.
$416
Roundtrip
found 23 hours ago
Tue, Oct 20 - Mon, Oct 26
FLL
Fort Lauderdale - Hollywood Intl.
PTY
Tocumen Intl.
$537
Roundtrip
found 17 hours ago
Sun, Sep 20 - Sun, Sep 27
MIA
Miami Intl.
PTY
Tocumen Intl.
$686
Roundtrip
found 13 hours ago
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All accommodation types in Santa Isabel
More Types of Hotels
- Hotels with Bars in Santa Isabel
- Hotels with a Pool in Santa Isabel
- Beach Hotels in Santa Isabel
- Family Hotels in Santa Isabel
- Hotels with Balconies in Santa Isabel
- Hotels with WiFi in Santa Isabel
- Hotels with Complimentary Breakfast in Santa Isabel
- Hotel with wifi in Santa Isabel
- Hotels with Air Conditioning in Santa Isabel