Río Sereno Vacations
Build a Flight + Hotel Bundle & Save up to $536 On Your Vacation*
Río Sereno Flight + Hotel packages
Price found within the past 48 hours. Click for updated prices.
Hotel Riu Plaza Panama
Bella Vista
Price was $1,221, price is now $880 per person
$880
per person
May 14 - May 19
found 18 hours ago
Roundtrip non-stop flight included
New York (JFK) to Panama City (PTY)
Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and 3 restaurants. Our guests praise the breakfast and the pool in our reviews. Popular attractions Via Espana and Avenida Balboa are located nearby.
Central Hotel Panama Casco Viejo
Casco Viejo
Save 100% on your flight
Price was $2,782, price is now $1,930 per person
$1,930
per person
Apr 17 - Apr 24
found 10 hours ago
Roundtrip flight included
Sioux Falls (FSD) to Panama City (PTY)
Book a stay at this spa hotel in Panama City. Enjoy free WiFi, a full-service spa, and 3 restaurants. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Cinta Costera and Amador Causeway are located nearby.
Megapolis Hotel Panamá
San Francisco
Price was $1,498, price is now $1,071 per person
$1,071
per person
May 14 - May 19
found 14 hours ago
Roundtrip non-stop flight included
New York (JFK) to Panama City (PTY)
Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Avenida Balboa and Via Espana are located nearby.
Dreams Playa Bonita Panama - All Inclusive
Price was $2,407, price is now $1,827 per person
$1,827
per person
Apr 17 - Apr 24
found 10 hours ago
Roundtrip flight included
Sioux Falls (FSD) to Panama City (PTY)
Book a stay at this beach property in Veracruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the pool and the helpful staff in our reviews. Popular attractions Amador Causeway and Albrook Shopping Mall are located nearby.
Hyatt Regency Panama City
Bella Vista
Price was $1,858, price is now $1,436 per person
$1,436
per person
Apr 17 - Apr 24
found 10 hours ago
Roundtrip flight included
Sioux Falls (FSD) to Panama City (PTY)
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, free valet parking, and a full-service spa. Popular attractions Via Espana and Avenida Balboa are located nearby.
Riande Aeropuerto Hotel & Casino
Price was $1,606, price is now $1,257 per person
$1,257
per person
Apr 17 - Apr 24
found 10 hours ago
Roundtrip flight included
Sioux Falls (FSD) to Panama City (PTY)
Book a stay at this family-friendly resort in Tocumen. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in our reviews. Popular attractions Metromall Panama and Los Pueblos Commercial Center are located nearby.
Top Hotel Deals
Hotel Bambito By Faranda Boutique, a member of Radisson Individuals
Volcan, Via Cerro Punta Volcan Chiriqui
23.02 km from city center
Book a stay at this family-friendly hotel in Volcan. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Barriles and Área Silvestre Protegida ...
Los Brezos Boutique Hotel
Calle Tercera Norte Volcan Chiriquí
22.79 km from city center
Book a stay at this business-friendly hotel in Volcan. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Barriles and Área Silvestre Protegida ...
Hotel Finca Lerida
Alto Quiel Los Naranjos Chiriqui
40.11 km from city center
Stay at this hotel in Los Naranjos. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Finca Lérida Coffee Estate and Los Ladrillos are located ...
Casa Grande Bambito Resort
Calle El Manantial Paso Ancho Chiriqui
24.67 km from city center
Book a stay at this family-friendly hotel in Paso Ancho. Enjoy free WiFi, free parking, and breakfast (surcharge). Popular attractions Barriles and Área Silvestre ...
Los Quetzales Ecolodge & Spa
Guadalupe Cerro Punta Chiriqui
30.21 km from city center
Book a stay at this spa lodge in Cerro Punta. Enjoy free WiFi, free parking, and a full-service spa. Popular attractions Finca Dracula Orchid Sanctuary and The ...
Hotel Dos Rios
43, Nueva California Nueva California
20.04 km from city center
Stay at this hotel in Nueva California. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Barriles and Área Silvestre Protegida Lagunas ...
Hostal Victoria Volcán Chiriquí S. A.
Volcan Chiriquí Nueva California Chiriquí
21.77 km from city center
Stay at this hostal in Nueva California. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Barriles and Área Silvestre Protegida Lagunas ...
Risco de Hugo
2 Volcancito Road Boquete Chiriquí Province
39.46 km from city center
Stay at this lodge in Boquete. Enjoy free WiFi, free parking, and furnished balconies. Popular attractions Finca Lérida Coffee Estate and Los Ladrillos are located ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top Flight Deals
These prices were available within the past 7 days. Prices quoted are per person, round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.
Sun, Jun 7 - Mon, Jun 8
PTY
Tocumen Intl.
DAV
Enrique Malek Intl.
$116 Roundtrip, found 3 days ago
$116
Roundtrip
found 3 days ago
Sun, Jun 7 - Mon, Jun 8
PTY
Tocumen Intl.
DAV
Enrique Malek Intl.
$140 Roundtrip, found 3 days ago
$140
Roundtrip
found 3 days ago
Sun, Jun 7 - Mon, Jun 8
PTY
Tocumen Intl.
DAV
Enrique Malek Intl.
$154 Roundtrip, found 3 days ago
$154
Roundtrip
found 3 days ago
Sun, Jun 7 - Mon, Jun 8
PTY
Tocumen Intl.
DAV
Enrique Malek Intl.
$164 Roundtrip, found 3 days ago
$164
Roundtrip
found 3 days ago