Southern Illinois In Southern Illinois 2025

Featured Southern Illinois Hotels with Restaurants

Drury Plaza Hotel Mt. Vernon

Drury Plaza Hotel Mt. Vernon

3 out of 5
145 North 44th Street  Mount Vernon IL
Fully refundableReserve now, pay when you stay
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Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destination

Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destination

3.5 out of 5
100 E Front St Metropolis IL
Opens in a new windowHarrah's Metropolis Hotel & Casino - A Caesars Rewards Destination
Drury Inn & Suites Marion

Drury Inn & Suites Marion

3 out of 5
2706 W DeYoung St Marion IL
Fully refundableReserve now, pay when you stay
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Drury Inn & Suites St. Louis O'Fallon, IL

Drury Inn & Suites St. Louis O'Fallon, IL

3 out of 5
1118 Central Park Drive O'Fallon IL
Fully refundableReserve now, pay when you stay
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Drury Inn & Suites St. Louis Collinsville

Drury Inn & Suites St. Louis Collinsville

3 out of 5
602 N Bluff Rd Collinsville IL
Fully refundableReserve now, pay when you stay
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Drury Inn & Suites St. Louis Fairview Heights

Drury Inn & Suites St. Louis Fairview Heights

3 out of 5
12 Ludwig Dr Fairview Heights IL
Fully refundableReserve now, pay when you stay
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La Quinta Inn & Suites by Wyndham Effingham

La Quinta Inn & Suites by Wyndham Effingham

3 out of 5
1103 Avenue Of Mid America Effingham IL
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Best Western Marion Hotel

Best Western Marion Hotel

2.5 out of 5
400 Comfort Dr Marion IL
Fully refundableReserve now, pay when you stay
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Country Inn & Suites by Radisson, Marion, IL

Country Inn & Suites by Radisson, Marion, IL

2.5 out of 5
1306 Halfway Road Marion IL
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La Quinta Inn & Suites by Wyndham Collinsville - St. Louis

La Quinta Inn & Suites by Wyndham Collinsville - St. Louis

3 out of 5
6 Gateway Dr Collinsville IL
Opens in a new windowLa Quinta Inn & Suites by Wyndham Collinsville - St. Louis
Comfort Inn & Suites Marion I-57

Comfort Inn & Suites Marion I-57

2.5 out of 5
2403 Black Diamond Dr Marion IL
Opens in a new windowComfort Inn & Suites Marion I-57
DoubleTree by Hilton Collinsville - St. Louis

DoubleTree by Hilton Collinsville - St. Louis

4 out of 5
1000 Eastport Plaza Dr Collinsville IL
Fully refundableReserve now, pay when you stay
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Super 8 by Wyndham Fairview Heights-St. Louis

Super 8 by Wyndham Fairview Heights-St. Louis

2 out of 5
45 Ludwig Dr Fairview Heights IL
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Country Inn & Suites by Radisson, Effingham, IL

Country Inn & Suites by Radisson, Effingham, IL

2.5 out of 5
1200 N Raney Effingham IL
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Comfort Inn & Suites O'Fallon - St. Louis Area

Comfort Inn & Suites O'Fallon - St. Louis Area

2 out of 5
116 Regency Park O'Fallon IL
Opens in a new windowComfort Inn & Suites O'Fallon - St. Louis Area
Radisson Hotel Fairview Heights - St. Louis

Radisson Hotel Fairview Heights - St. Louis

3 out of 5
319 Fountains Pkwy Fairview Heights IL
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Rodeway Inn Effingham North

Rodeway Inn Effingham North

2 out of 5
1400 Thelma Keller Ave Effingham IL
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Days Inn by Wyndham Collinsville/St. Louis

Days Inn by Wyndham Collinsville/St. Louis

2.5 out of 5
12 Commerce Drive Collinsville IL
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Southern Illinois, Illinois, United States of America
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