
Southern Illinois In Southern Illinois 2025
Featured Southern Illinois Hotels with Restaurants

Drury Plaza Hotel Mt. Vernon
145 North 44th Street Mount Vernon IL
Fully refundableReserve now, pay when you stay

Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destination
100 E Front St Metropolis IL

Drury Inn & Suites Marion
2706 W DeYoung St Marion IL
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Drury Inn & Suites St. Louis O'Fallon, IL
1118 Central Park Drive O'Fallon IL
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Drury Inn & Suites St. Louis Collinsville
602 N Bluff Rd Collinsville IL
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Drury Inn & Suites St. Louis Fairview Heights
12 Ludwig Dr Fairview Heights IL
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La Quinta Inn & Suites by Wyndham Effingham
1103 Avenue Of Mid America Effingham IL

Best Western Marion Hotel
400 Comfort Dr Marion IL
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Country Inn & Suites by Radisson, Marion, IL
1306 Halfway Road Marion IL

La Quinta Inn & Suites by Wyndham Collinsville - St. Louis
6 Gateway Dr Collinsville IL

Comfort Inn & Suites Marion I-57
2403 Black Diamond Dr Marion IL

DoubleTree by Hilton Collinsville - St. Louis
1000 Eastport Plaza Dr Collinsville IL
Fully refundableReserve now, pay when you stay

Super 8 by Wyndham Fairview Heights-St. Louis
45 Ludwig Dr Fairview Heights IL

Country Inn & Suites by Radisson, Effingham, IL
1200 N Raney Effingham IL

Comfort Inn & Suites O'Fallon - St. Louis Area
116 Regency Park O'Fallon IL

Radisson Hotel Fairview Heights - St. Louis
319 Fountains Pkwy Fairview Heights IL

Rodeway Inn Effingham North
1400 Thelma Keller Ave Effingham IL

Days Inn by Wyndham Collinsville/St. Louis
12 Commerce Drive Collinsville IL
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.