Business Hotels in Southern Illinois 2025

Featured Southern Illinois Business Hotels

Drury Inn & Suites Marion

Drury Inn & Suites Marion

3 out of 5
2706 W DeYoung St Marion IL
Fully refundableReserve now, pay when you stay
Opens in a new windowDrury Inn & Suites Marion
Radisson Hotel Fairview Heights - St. Louis

Radisson Hotel Fairview Heights - St. Louis

3 out of 5
319 Fountains Pkwy Fairview Heights IL
Opens in a new windowRadisson Hotel Fairview Heights - St. Louis
Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destination

Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destination

3.5 out of 5
100 E Front St Metropolis IL
Opens in a new windowHarrah's Metropolis Hotel & Casino - A Caesars Rewards Destination
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Super 8 by Wyndham Mattoon

Super 8 by Wyndham Mattoon

2 out of 5
205 Mcfall Rd Mattoon IL
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Super 8 by Wyndham Collinsville St. Louis

Super 8 by Wyndham Collinsville St. Louis

2 out of 5
2 Gateway Dr Collinsville IL
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Red Roof Inn St Louis - Troy, IL

Red Roof Inn St Louis - Troy, IL

2 out of 5
2030 Formosa Road Troy IL
Fully refundableReserve now, pay when you stay
Opens in a new windowRed Roof Inn St Louis - Troy, IL
Econo Lodge Inn & Suites Fairview Heights - St. Louis

Econo Lodge Inn & Suites Fairview Heights - St. Louis

2 out of 5
305 Salem Pl Fairview Heights IL
Opens in a new windowEcono Lodge Inn & Suites Fairview Heights - St. Louis
Super 8 by Wyndham Belleville St. Louis Area

Super 8 by Wyndham Belleville St. Louis Area

2 out of 5
600 East Main Street Belleville IL
Opens in a new windowSuper 8 by Wyndham Belleville St. Louis Area
Comfort Inn & Suites Marion I-57

Comfort Inn & Suites Marion I-57

2.5 out of 5
2403 Black Diamond Dr Marion IL
Opens in a new windowComfort Inn & Suites Marion I-57
Days Inn by Wyndham Collinsville/St. Louis

Days Inn by Wyndham Collinsville/St. Louis

2.5 out of 5
12 Commerce Drive Collinsville IL
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Holiday Inn Express & Suites Effingham by IHG

Holiday Inn Express & Suites Effingham by IHG

2.5 out of 5
1604 West Fayette Avenue Effingham IL
Fully refundable
Opens in a new windowHoliday Inn Express & Suites Effingham by IHG
La Quinta Inn & Suites by Wyndham Collinsville - St. Louis

La Quinta Inn & Suites by Wyndham Collinsville - St. Louis

3 out of 5
6 Gateway Dr Collinsville IL
Opens in a new windowLa Quinta Inn & Suites by Wyndham Collinsville - St. Louis
Holiday Inn Express Troy by IHG

Holiday Inn Express Troy by IHG

2.5 out of 5
2011 Formosa Road Troy IL
Fully refundable
Opens in a new windowHoliday Inn Express Troy by IHG
Country Inn & Suites by Radisson, Marion, IL

Country Inn & Suites by Radisson, Marion, IL

2.5 out of 5
1306 Halfway Road Marion IL
Opens in a new windowCountry Inn & Suites by Radisson, Marion, IL
Comfort Inn & Suites O'Fallon - St. Louis Area

Comfort Inn & Suites O'Fallon - St. Louis Area

2 out of 5
116 Regency Park O'Fallon IL
Opens in a new windowComfort Inn & Suites O'Fallon - St. Louis Area
Holiday Inn Express & Suites Edwardsville by IHG

Holiday Inn Express & Suites Edwardsville by IHG

2.5 out of 5
1000 Plummer Drive Edwardsville IL
Fully refundable
Opens in a new windowHoliday Inn Express & Suites Edwardsville by IHG
Holiday Inn Express & Suites Mattoon by IHG

Holiday Inn Express & Suites Mattoon by IHG

2.5 out of 5
121 Swords Dr Mattoon IL
Fully refundable
Opens in a new windowHoliday Inn Express & Suites Mattoon by IHG
Drury Inn & Suites St. Louis O'Fallon, IL

Drury Inn & Suites St. Louis O'Fallon, IL

3 out of 5
1118 Central Park Drive O'Fallon IL
Fully refundableReserve now, pay when you stay
Opens in a new windowDrury Inn & Suites St. Louis O'Fallon, IL
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Southern Illinois, Illinois, United States of America
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