Business Hotels in Southern Illinois 2025
Featured Southern Illinois Business Hotels
Drury Inn & Suites Marion
2706 W DeYoung St Marion IL
Fully refundableReserve now, pay when you stay
Radisson Hotel Fairview Heights - St. Louis
319 Fountains Pkwy Fairview Heights IL
Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destination
100 E Front St Metropolis IL
Save an average of 15% on thousands of hotels when you're signed in
Super 8 by Wyndham Mattoon
205 Mcfall Rd Mattoon IL
Super 8 by Wyndham Collinsville St. Louis
2 Gateway Dr Collinsville IL
Red Roof Inn St Louis - Troy, IL
2030 Formosa Road Troy IL
Fully refundableReserve now, pay when you stay
Econo Lodge Inn & Suites Fairview Heights - St. Louis
305 Salem Pl Fairview Heights IL
Super 8 by Wyndham Belleville St. Louis Area
600 East Main Street Belleville IL
Comfort Inn & Suites Marion I-57
2403 Black Diamond Dr Marion IL
Days Inn by Wyndham Collinsville/St. Louis
12 Commerce Drive Collinsville IL
Holiday Inn Express & Suites Effingham by IHG
1604 West Fayette Avenue Effingham IL
Fully refundable
La Quinta Inn & Suites by Wyndham Collinsville - St. Louis
6 Gateway Dr Collinsville IL
Holiday Inn Express Troy by IHG
2011 Formosa Road Troy IL
Fully refundable
Country Inn & Suites by Radisson, Marion, IL
1306 Halfway Road Marion IL
Comfort Inn & Suites O'Fallon - St. Louis Area
116 Regency Park O'Fallon IL
Holiday Inn Express & Suites Edwardsville by IHG
1000 Plummer Drive Edwardsville IL
Fully refundable
Holiday Inn Express & Suites Mattoon by IHG
121 Swords Dr Mattoon IL
Fully refundable
Drury Inn & Suites St. Louis O'Fallon, IL
1118 Central Park Drive O'Fallon IL
Fully refundableReserve now, pay when you stay
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.