Downtown Vacation Packages for 2025

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Top Hotel Deals

Quality Inn Seneca Clemson Area US-123

Quality Inn Seneca Clemson Area US-123

2.5 out of 5
226 Hi Tech Rd, Seneca, SC
0.59 km from Downtown
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
Days Inn by Wyndham Anderson

Days Inn by Wyndham Anderson

2 out of 5
1007 George Smith Mill Rd, Anderson, SC
25.64 km from Downtown
Book a stay at this business-friendly motel in Anderson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
Wooded Cottage - 3 Mi to Clemson University

Wooded Cottage - 3 Mi to Clemson University

3 out of 5
12.41 km from Downtown
Stay at this 3-star cottage in Clemson. Enjoy free parking and air conditioning. Popular attractions Clemson Area African American Museum and Larry W. Abernathy ...
Best Western Plus Clemson Hotel & Conference Center

Best Western Plus Clemson Hotel & Conference Center

2.5 out of 5
1310 Tiger Blvd, Clemson, SC
11.78 km from Downtown
Book a stay at this business-friendly hotel in Clemson. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the helpful staff and the ...
Comfort Inn & Suites Clemson - University Area

Comfort Inn & Suites Clemson - University Area

2.5 out of 5
1305 Tiger Blvd, Clemson, SC
11.67 km from Downtown
Book a stay at this business-friendly hotel in Clemson. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the helpful staff and the ...
The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson

4 out of 5
110 Sloan St, Clemson, SC
10.61 km from Downtown
Stay at this 4-star hotel in Clemson. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the clean rooms in our ...
Lakeside Lodge Clemson

Lakeside Lodge Clemson

2.5 out of 5
13500 Clemson Blvd, Seneca, SC
8.58 km from Downtown
Stay at this hotel in Seneca. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
Microtel Inn & Suites by Wyndham Anderson/Clemson

Microtel Inn & Suites by Wyndham Anderson/Clemson

2 out of 5
102 Electric City Blvd, Anderson, SC
24.8 km from Downtown
Book a stay at this business-friendly hotel in Anderson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
Hilton Garden Inn Anderson

Hilton Garden Inn Anderson

3 out of 5
115 Destination Blvd, Anderson, SC
25.66 km from Downtown
Stay at this 3-star business-friendly hotel in Anderson. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and the ...
Inn @ Clemson

Inn @ Clemson

2.5 out of 5
1303 Tiger Blvd, Clemson, SC
11.64 km from Downtown
Book a stay at this business-friendly hotel in Clemson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
Clemson University's James F. Martin Inn

Clemson University's James F. Martin Inn

3 out of 5
240 Madren Center Drive, Clemson, SC
10.3 km from Downtown
Stay at this 3-star golf hotel in Clemson. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff and the clean rooms in our ...
Woodspring Suites Anderson North I-85

Woodspring Suites Anderson North I-85

2.5 out of 5
155 Threlkeld Boulevard, Anderson, SC
25.37 km from Downtown
Stay at this hotel in Anderson. Enjoy free WiFi, free parking, and a 24-hour fitness center. Popular attractions Regal Starlight - Anderson and Anderson Civic ...
Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area

2.5 out of 5
800 BYPASS 123, Seneca, SC
2.01 km from Downtown
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the helpful staff in our reviews. ...
Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area

2.5 out of 5
1011 East North 1st Street, Seneca, SC
2.18 km from Downtown
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area

2 out of 5
11015 N Radio Station Rd, Seneca, SC
3.11 km from Downtown
Stay at this motel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Applewood ...
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Flight Deals

These prices were available within the past 7 days. Prices quoted are per person, round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Wed, Nov 19 - Thu, Nov 27
DCA
Ronald Reagan Washington National
GSP
Greenville-Spartanburg Intl.
$204 Roundtrip, found 15 hours ago
$204
Roundtrip
found 15 hours ago
Select American Airlines flight, departing Wed, Nov 19 from Ronald Reagan Washington National to Greenville-Spartanburg Intl., returning Thu, Nov 27, priced at $204 found 15 hours ago
American Airlines
Sun, Nov 9 - Sun, Nov 16
LGA
LaGuardia
GSP
Greenville-Spartanburg Intl.
$219 Roundtrip, found 5 days ago
$219
Roundtrip
found 5 days ago
Select American Airlines flight, departing Sun, Nov 9 from LaGuardia to Greenville-Spartanburg Intl., returning Sun, Nov 16, priced at $219 found 5 days ago
Delta
Tue, Nov 18 - Mon, Nov 24
DCA
Ronald Reagan Washington National
GSP
Greenville-Spartanburg Intl.
$224 Roundtrip, found 15 hours ago
$224
Roundtrip
found 15 hours ago
Select Delta flight, departing Tue, Nov 18 from Ronald Reagan Washington National to Greenville-Spartanburg Intl., returning Mon, Nov 24, priced at $224 found 15 hours ago
United
Fri, Dec 5 - Tue, Dec 9
DFW
Dallas-Fort Worth Intl.
GSP
Greenville-Spartanburg Intl.
$396 Roundtrip, found 3 days ago
$396
Roundtrip
found 3 days ago
Select United flight, departing Fri, Dec 5 from Dallas-Fort Worth Intl. to Greenville-Spartanburg Intl., returning Tue, Dec 9, priced at $396 found 3 days ago