Business Hotels in Chillicothe 2026
Photo by Aaron Littler
Featured Chillicothe Business Hotels
Quality Inn & Suites
24517 US Highway 23 S Circleville OH
Fairfield Inn and Suites by Marriott Chillicothe
300 North Plaza Boulevard Chillicothe OH
Fully refundableReserve now, pay when you stay
Christopher Inn and Suites
30 North Plaza Boulevard Chillicothe OH
Fully refundableReserve now, pay when you stay
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Comfort Inn
7525 US 23 Piketon OH
Quality Inn
605 E Main St Jackson OH
Quality Inn Chillicothe
20 N Plaza Blvd Chillicothe OH
Best Western Adena Inn
1250 N Bridge Street Chillicothe OH
Fully refundableReserve now, pay when you stay
Red Roof Inn Jackson, OH
1000 Acy Ave Jackson OH
Fully refundableReserve now, pay when you stay
Holiday Inn Express Circleville by IHG
23911 Us Rt 23 S Circleville OH
Fully refundable
Ameristay Hotel Inn & Suites Waverly
800 W. Emmitt Ave Waverly OH
Hampton Inn & Suites Chillicothe
100 N Plaza Blvd Chillicothe OH
Fully refundableReserve now, pay when you stay
Holiday Inn Express Chillicothe East by IHG
1003 E Main Street Chillicothe OH
Fully refundable
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.