Cayos Los Grullos Vacation Packages for 2026
Build a Flight + Hotel Bundle & Save up to $536 On Your Vacation*
Cayos Los Grullos Flight + Hotel packages
Price found within the past 48 hours. Click for updated prices.
Riande Aeropuerto Hotel & Casino
Price was $1,727, price is now $1,168 per person
$1,168
per person
Sep 23 - Sep 30
found 1 day ago
Roundtrip non-stop flight included
Detroit (DTW) to Panama City (PTY)
Book a stay at this family-friendly resort in Tocumen. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in our reviews. Popular attractions Metromall Panama and Los Pueblos Commercial Center are located nearby.
Central Hotel Panama Casco Viejo
Casco Viejo
Save 100% on your flight
Price was $2,831, price is now $1,345 per person
$1,345
per person
Sep 23 - Sep 30
found 1 day ago
Roundtrip non-stop flight included
Detroit (DTW) to Panama City (PTY)
Book a stay at this spa hotel in Panama City. Enjoy free WiFi, a full-service spa, and 3 restaurants. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.
The staff are very professional and helpful; the property is in excellent condition.
Reviewed on Aug 1, 2026
Megapolis Hotel Panamá
San Francisco
Save 100% on your flight
Price was $2,593, price is now $1,624 per person
$1,624
per person
Sep 23 - Sep 30
found 1 day ago
Roundtrip non-stop flight included
Detroit (DTW) to Panama City (PTY)
Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Albrook Shopping Mall and Avenida Balboa are located nearby.
Hotel Riu Plaza Panama
Bella Vista
Price was $1,650, price is now $1,180 per person
$1,180
per person
Sep 23 - Sep 30
found 1 day ago
Roundtrip non-stop flight included
Detroit (DTW) to Panama City (PTY)
Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and 3 restaurants. Our guests praise the breakfast and the pool in our reviews. Popular attractions Albrook Shopping Mall and Via Espana are located nearby.
Everything was wonderful, the service, the employees, hospitality,the food, the environment. The cleanest of the hotel and overall the staff were great
Reviewed on Aug 1, 2026
Hyatt Regency Panama City
Bella Vista
Price was $1,717, price is now $1,282 per person
$1,282
per person
Sep 23 - Sep 30
found 1 day ago
Roundtrip non-stop flight included
Detroit (DTW) to Panama City (PTY)
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, free valet parking, and 2 restaurants. Popular attractions Albrook Shopping Mall and Via Espana are located nearby.
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Reviewed on Aug 1, 2026
Las Americas Golden Tower Panama
San Francisco
Price was $1,630, price is now $1,285 per person
$1,285
per person
Sep 23 - Sep 30
found 1 day ago
Roundtrip non-stop flight included
Detroit (DTW) to Panama City (PTY)
Book a stay at this spa hotel in Panama City. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Albrook Shopping Mall and Avenida Balboa are located nearby.
Tuve una muy buena experiencia. El lugar estaba limpio, bien ubicado y el personal fue muy amable y atento durante toda la estancia. El proceso de check-in fue rápido y todo funcionó tal como se esperaba.
Sin duda volvería a hospedarme aquí y lo recomendaría a quienes busquen una opción cómoda, con buen servicio y una excelente relación calidad-precio.
Reviewed on Jul 31, 2026
Don't see what you're looking for?
See all available trips from Columbus to Cayos Los Grullos
View all tripsTop Hotel Deals
San Blas Private Beach Cabin
Nusatupo Narganá Guna Yala
0.56 km from city center
Book a stay at this beach cabin in Narganá. Enjoy free breakfast, a beach locale, and an airport shuttle (surcharge). Popular attractions Museum of the Kuna ...
San Blas Private Over-the-Water Cabin
Nusatupo Narganá Guna Yala
0.56 km from city center
Book a stay at this beach cabin in Narganá. Enjoy free breakfast, a beach locale, and an airport shuttle (surcharge). Popular attractions Museum of the Kuna ...
Cabanas Narasgandub - Naranjo Chico
Kuna Yala Narganá Guna Yala
0.59 km from city center
Book a stay at this beach hotel in Narganá. Enjoy free breakfast, a 24-hour front desk, and an airport shuttle (surcharge). Popular attraction Museum of the ...
San Blas Secluded Paradise Beach Cabins
Nusatupo Narganá Guna Yala
0.56 km from city center
Book a stay at this beach cabin in Narganá. Enjoy free breakfast, a beach locale, and daily housekeeping. Popular attractions Museum of the Kuna Nation and Isla ...
Cocoloco - Catamaran Lagoon 52F SAN BLAS
El Porvenir Narganá Guna Yala
16.92 km from city center
Book a stay at this beach cruise ship in San Blas Islands. Enjoy free breakfast, free WiFi, and a beach locale. Popular attractions Porvenir Museum and Isla ...
san blas luxury tour
guna yala Nusatupo Guna Yala
9.03 km from city center
Book a stay at this beach cabin in Narganá. Enjoy free breakfast, free WiFi, and a private beach.
Private Ocean-Front Cabin with private bathroom on San Blas Island
Diablo Island Narganá Guna Yala
10.39 km from city center
Stay at this hotel in San Blas Islands. Enjoy free breakfast, an airport shuttle (surcharge), and a garden. Popular attractions Isla Diablo and Isla Chichime ...
Konsenda San Blas
Llano Cartí Km 11 El Llano Panamá Province
30.65 km from city center
Stay at this hotel in El Llano. Enjoy free breakfast, free parking, and a garden.
Private Bedroom on Paradise San Blas Island
Isla Yansailadup Narganá Guna Yala
9.87 km from city center
Stay at this guesthouse in Narganá. Enjoy free breakfast, a beach locale, and an airport shuttle (surcharge). Popular attractions Isla Diablo and Museum of the ...
Discovery Gunayar
Archipiélago de San Blas Narganá Guna Yala
5.89 km from city center
Book a stay at this beach lodge in Narganá. Enjoy free breakfast, a beach locale, and an airport shuttle (surcharge). Popular attractions Isla Chichime and Isla ...
San Blas Tour Aridub
Urgandi, Guna Yala, Panamá Narganá Guna Yala
8.9 km from city center
Book a stay at this beach cabin in Narganá. Enjoy beach cabanas (surcharge), a beach shuttle (surcharge), and daily housekeeping.
San Blas Private Oceanfront Cabin
C5W9 4M Nusatupo Narganá Guna Yala
9.03 km from city center
Book a stay at this beach cabin in Narganá. Enjoy free breakfast, a beach locale, and an airport shuttle (surcharge).
Private wood Cabins on San Blas island - private bathroom
Wailidup Island Narganá Guna Yala
11.46 km from city center
Stay at this hotel in San Blas Islands. Enjoy free breakfast, a beach locale, and a marina. Popular attractions Isla Chichime and Isla Diablo are located ...
Don't see what you're looking for?
See all available properties in Cayos Los Grullos
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top Flight Deals
These prices were available within the past 7 days. Prices quoted are per person, round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.
Thu, Oct 15 - Mon, Oct 26
MIA
Miami Intl.
PTY
Tocumen Intl.
$422 Roundtrip, found 3 days ago
$422
Roundtrip
found 3 days ago
Tue, Sep 15 - Sun, Sep 27
MIA
Miami Intl.
PTY
Tocumen Intl.
$438 Roundtrip, found 5 days ago
$438
Roundtrip
found 5 days ago
Sat, Oct 3 - Sat, Oct 31
MIA
Miami Intl.
PTY
Tocumen Intl.
$450 Roundtrip, found 4 days ago
$450
Roundtrip
found 4 days ago
Sun, Sep 20 - Sun, Sep 27
FLL
Fort Lauderdale - Hollywood Intl.
PTY
Tocumen Intl.
$477 Roundtrip, found 4 days ago
$477
Roundtrip
found 4 days ago
Tue, Oct 27 - Mon, Nov 16
ATL
Hartsfield-Jackson Atlanta Intl.
PTY
Tocumen Intl.
$590 Roundtrip, found 2 days ago
$590
Roundtrip
found 2 days ago