2026 5 Star Hotels in Santa Cruz

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Featured Santa Cruz 5 Star Hotels

Hotel Alfonso XIII, a Luxury Collection Hotel, Seville

Hotel Alfonso XIII, a Luxury Collection Hotel, Seville

5 out of 5
San Fernando 2 Seville Seville
Fully refundableReserve now, pay when you stay
Hotel Alfonso XIII, a Luxury Collection Hotel, Seville
EME Catedral Mercer Hotel

EME Catedral Mercer Hotel

5 out of 5
Calle Alemanes 27 Seville Seville
EME Catedral Mercer Hotel
See all 432 properties in Santa Cruz
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.