2026 4 Star Hotels in Main Street Fort Pierce

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Featured Main Street Fort Pierce 4 Star Hotels

Costa d'Este Beach Resort and Spa

Costa d'Este Beach Resort and Spa

4 out of 5
3244 Ocean Drive Vero Beach FL
Fully refundableReserve now, pay when you stay
Costa d'Este Beach Resort and Spa
Hutchinson Shores Resort & Spa

Hutchinson Shores Resort & Spa

4 out of 5
3793 NE Ocean Boulevard Jensen Beach FL
Fully refundableReserve now, pay when you stay
Hutchinson Shores Resort & Spa
Kimpton Vero Beach Hotel & Spa by IHG

Kimpton Vero Beach Hotel & Spa by IHG

4 out of 5
3500 Ocean Dr Vero Beach FL
Fully refundable
Kimpton Vero Beach Hotel & Spa by IHG
402 On Hutchinson Island

402 On Hutchinson Island

4.5 out of 5
9800 S Ocean Drive Jensen Beach FL
402 On Hutchinson Island
Ocean Drive Villas- Unit A

Ocean Drive Villas- Unit A

4 out of 5
711 South Ocean Drive Fort Pierce FL
Ocean Drive Villas- Unit A
404 On Hutchinson Island

404 On Hutchinson Island

4 out of 5
9800 S Ocean Dr Jensen Beach FL
404 On Hutchinson Island
The Old Apartment

The Old Apartment

4 out of 5
219 N 2nd Street Fort Pierce FL
The Old Apartment
Sunrise Island Retreat

Sunrise Island Retreat

4 out of 5
1703 Francis Court Fort Pierce FL
Sunrise Island Retreat
Ocean Song House

Ocean Song House

4 out of 5
1931 Cypress Avenue Fort Pierce FL
Ocean Song House
See all 2,951 properties in Main Street Fort Pierce
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.