Otay Mesa, CA

San Diego

A city skyline with high-rise buildings and a bridge over a body of water.

An aerial view of a densely populated city with a mix of residential and commercial buildings, surrounded by greenery and a clear sky.

A hillside town with a winding road, a bridge in the distance, and a river in the foreground.

Visit Otay Mesa

Things to do

Hotels

San Diego Travel Guide

Stay near popular Otay Mesa attractions

Cross Border Xpress

Cross Border Xpress is just one of the places to see in San Diego, so why not enjoy the other things to explore during your travels? Visit the shops in this family-friendly area, or simply enjoy its restaurants.

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Things to do

Tour from San Diego to Rosarito / Portales / Puerto Nuevo Lobster

Tour of San Diego>Rosarito >Giant Christ>Puerto Nuevo Lobster

$150

per adult

Tijuana Downtown Self Guided Walking Tour

$10

per adult

100% of travellers recommend

Tijuana Urban Art Walk from San Diego

$80

per adult

Introduction Rosarito Day Tour from San Diego

$157

per adult

Mexican Street Food: Tijuana Day Trip from San Diego

$129

per adult

100% of travellers recommend

Intro to Mexico Walking Tour: Tijuana Day Trip from San Diego

$73

per adult

100% of travellers recommend

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Otay Mesa Hotel Deals

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

2296 Niels Bohr Ct San Diego CA

Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...

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Wyndham San Diego Bayside

1355 N Harbor Drive San Diego CA

Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...

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Hard Rock Hotel San Diego

207 5th Ave San Diego CA

Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the helpful staff and the convenient parking in our reviews. ...

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Handlery Hotel

950 Hotel Cir N San Diego CA

Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the helpful staff ...

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Paradise Point Resort & Spa

1404 Vacation Rd San Diego CA

Book a stay at this beach resort in San Diego. Enjoy free WiFi, 5 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...

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Best Western Seven Seas

411 Hotel Circle South San Diego CA

Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, free parking, and 2 hot tubs. Our guests praise the pool and the restaurant in our ...

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See all 5,065 properties in Otay Mesa

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Otay Mesa

Find the best Otay Mesa areas and neighborhoods for the activities you enjoy most. Learn more about Otay Mesa

A large stadium with the sign "Cobo Park" and palm trees around it.

Downtown San Diego

Petco Park and Port of San Diego are a few top attractions in Downtown San Diego. Hop around the city on the metro at Civic Center Station or Civic Center Station and check out the area's fantastic nightlife, fascinating museums, and beautiful waterfront views.

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A pier extending into the ocean with buildings at the end, under a partly cloudy sky.

Pacific Beach

The stunning beaches and fantastic nightlife are just a few highlights of Pacific Beach. Make a stop by Mission Bay or Pacific Beach while you're exploring the area.

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Gaslamp Quarter

Fantastic nightlife and popular shops are a few of the things travelers enjoy most about Gaslamp Quarter. A visit to Gaslamp Museum at the Davis-Horton House or Nova SD is also recommended, and you can jump aboard the metro at Gaslamp Quarter Station to get around town.

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