2026 4 Star Hotels in Mainz City Center

Choose two or more items and save on your trip:

Featured Mainz City Center 4 Star Hotels

NH Collection Frankfurt Spin Tower

NH Collection Frankfurt Spin Tower

4.5 out of 5
Güterplatz 1 Frankfurt Hessen
Fully refundableReserve now, pay when you stay
NH Collection Frankfurt Spin Tower
NH Frankfurt Airport

NH Frankfurt Airport

4 out of 5
Moerfelder Strasse 113 Kelsterbach HE
Fully refundableReserve now, pay when you stay
NH Frankfurt Airport
Radisson Blu Hotel, Frankfurt

Radisson Blu Hotel, Frankfurt

4.5 out of 5
Franklinstr. 65 Frankfurt HE
Fully refundableReserve now, pay when you stay
Radisson Blu Hotel, Frankfurt
The Frankfurt Hotel

The Frankfurt Hotel

4 out of 5
Am Hauptbahnhof 2 Frankfurt HE
The Frankfurt Hotel
Hotel Monopol

Hotel Monopol

4 out of 5
Mannheimer Str. 11-13 Frankfurt HE
Hotel Monopol
Welcome Hotel Darmstadt City Center

Welcome Hotel Darmstadt City Center

4 out of 5
Karolinenplatz 4 Darmstadt HE
Fully refundableReserve now, pay when you stay
Welcome Hotel Darmstadt City Center
Best Western Plus Welcome Hotel Frankfurt

Best Western Plus Welcome Hotel Frankfurt

4 out of 5
Leonardo-da-Vinci-Allee 2 Frankfurt HE
Fully refundableReserve now, pay when you stay
Best Western Plus Welcome Hotel Frankfurt
ATLANTIC Hotel Frankfurt - New opening

ATLANTIC Hotel Frankfurt - New opening

4.5 out of 5
Europa-Allee 68 Frankfurt
Fully refundableReserve now, pay when you stay
ATLANTIC Hotel Frankfurt - New opening
Vital Hotel Frankfurt

Vital Hotel Frankfurt

4.5 out of 5
Niederhofheimer Straße 67 Hofheim am Taunus HE
Fully refundableReserve now, pay when you stay
Vital Hotel Frankfurt
See all 1,344 properties in Mainz City Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.