Opelousas Vacations

Build a Flight + Hotel Bundle & Save up to $536 On Your Vacation*

Choose two or more items and save on your trip:

Top Hotel Deals

Days Inn & Suites by Wyndham Opelousas

Days Inn & Suites by Wyndham Opelousas

2 out of 5
5761 I-49 S Service Rd, Opelousas, LA
2.32 km from city center
Book a stay at this business-friendly hotel in Opelousas. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
Evangeline Downs Hotel, Ascend Hotel Collection

Evangeline Downs Hotel, Ascend Hotel Collection

3 out of 5
2235 Creswell Ln Ext, Lot B, Opelousas, LA
2.19 km from city center
Stay at this 3-star business-friendly hotel in Opelousas. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
Holiday Inn Express & Suites Opelousas by IHG

Holiday Inn Express & Suites Opelousas by IHG

3 out of 5
5696 I-49 N Service Rd, Opelousas, LA
2.29 km from city center
Stay at this 3-star business-friendly hotel in Opelousas. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
Motel 6 Opelousas, LA

Motel 6 Opelousas, LA

2 out of 5
4165 I-49 S Service Rd, Opelousas, LA
6.35 km from city center
Stay at this motel in Opelousas. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions South Park and Evangeline Downs Racetrack & Casino ...
Spark by Hilton Opelousas

Spark by Hilton Opelousas

2.5 out of 5
5454 I-49 North Service Rd., Opelousas, LA
2.57 km from city center
Book a stay at this business-friendly hotel in Opelousas. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the property condition in our ...
Hampton Inn Opelousas

Hampton Inn Opelousas

2.5 out of 5
1700 Commerce Blvd, Opelousas, LA
1.84 km from city center
Stay at this hotel in Opelousas. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Evangeline Downs Racetrack & Casino and Jim Bowie Museum ...
Studio 6 Opelousas, LA

Studio 6 Opelousas, LA

2 out of 5
5791 I-49 S Service Road, Opelousas, LA
2.31 km from city center
Stay at this hotel in Opelousas. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Evangeline Downs Racetrack & Casino and South Park ...
DoubleTree by Hilton Hotel Lafayette

DoubleTree by Hilton Hotel Lafayette

4 out of 5
1521 W Pinhook Rd, Lafayette, LA
37.93 km from city center
Book a stay at this business-friendly hotel in Lafayette. Enjoy free WiFi, free parking, and 2 bars/lounges. Our guests praise the helpful staff and the clean ...
La Quinta Inn & Suites by Wyndham Lafayette Oil Center

La Quinta Inn & Suites by Wyndham Lafayette Oil Center

2.5 out of 5
1321 W Pinhook Rd, Lafayette, LA
37.66 km from city center
Book a stay at this business-friendly hotel in Lafayette. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
Microtel Inn & Suites by Wyndham Scott/Lafayette

Microtel Inn & Suites by Wyndham Scott/Lafayette

2 out of 5
301 Ambassador Caffery Pkwy, Scott, LA
32.65 km from city center
Stay at this hotel in Scott. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
Smart Stay Inn

Smart Stay Inn

2 out of 5
1620 N University Ave, Lafayette, LA
31.72 km from city center
Stay at this hotel in Lafayette. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
Comfort Suites Oil Center

Comfort Suites Oil Center

2.5 out of 5
114 Rue Fernand, Lafayette, LA
38.39 km from city center
Book a stay at this business-friendly hotel in Lafayette. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
Tru by Hilton Lafayette River Ranch

Tru by Hilton Lafayette River Ranch

2.5 out of 5
1310 Camellia Blvd, Lafayette, LA
40.86 km from city center
Stay at this hotel in Lafayette. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Cajundome ...
Holiday Inn Express Hotel & Suites Lafayette by IHG

Holiday Inn Express Hotel & Suites Lafayette by IHG

2.5 out of 5
3903 Ambassador Caffery Pkwy, Lafayette, LA
40.59 km from city center
Book a stay at this business-friendly hotel in Lafayette. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
Hilton Garden Inn Lafayette/Cajundome

Hilton Garden Inn Lafayette/Cajundome

3 out of 5
2350 W Congress St, Lafayette, LA
35.08 km from city center
Stay at this 3-star business-friendly hotel in Lafayette. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff in our ...
Don't see what you're looking for?
See all available properties in Opelousas
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Flight Deals

These prices were available within the past 7 days. Prices quoted are per person, round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Tue, Jun 24 - Mon, Jun 30
IND
Indianapolis Intl.
LFT
Lafayette Regional
$249 Roundtrip, found 6 days ago
$249
Roundtrip
found 6 days ago
Select Delta flight, departing Tue, Jun 24 from Indianapolis Intl. to Lafayette Regional, returning Mon, Jun 30, priced at $249 found 6 days ago
United
Tue, Jun 24 - Mon, Jun 30
IND
Indianapolis Intl.
LFT
Lafayette Regional
$249 Roundtrip, found 6 days ago
$249
Roundtrip
found 6 days ago
Select United flight, departing Tue, Jun 24 from Indianapolis Intl. to Lafayette Regional, returning Mon, Jun 30, priced at $249 found 6 days ago
United
Tue, Jun 24 - Mon, Jun 30
IND
Indianapolis Intl.
LFT
Lafayette Regional
$254 Roundtrip, found 6 days ago
$254
Roundtrip
found 6 days ago
Select United flight, departing Tue, Jun 24 from Indianapolis Intl. to Lafayette Regional, returning Mon, Jun 30, priced at $254 found 6 days ago
American Airlines
Tue, Jun 24 - Mon, Jun 30
IND
Indianapolis Intl.
LFT
Lafayette Regional
$329 Roundtrip, found 6 days ago
$329
Roundtrip
found 6 days ago
Select American Airlines flight, departing Tue, Jun 24 from Indianapolis Intl. to Lafayette Regional, returning Mon, Jun 30, priced at $329 found 6 days ago