Lake City Vacations

Build a Flight + Hotel Bundle & Save up to $536 On Your Vacation*

Choose two or more items and save on your trip:

Top Hotel Deals

The Inn at the Crossroads

The Inn at the Crossroads

128 West Main Street Lake City SC
0.16 km from city center
Book a stay at this business-friendly hotel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
Quality Inn & Suites Lake City

Quality Inn & Suites Lake City

202 N Ron Mcnair Blvd Lake City SC
0.81 km from city center
Book a stay at this business-friendly hotel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
Days Inn by Wyndham Lake City

Days Inn by Wyndham Lake City

170 S Ron Mcnair Blvd Lake City SC
0.64 km from city center
Book a stay at this business-friendly motel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Lynches Lake Historical Society ...
Comfort Inn & Suites Florence Center Area

Comfort Inn & Suites Florence Center Area

527 Woody Jones Blvd Florence SC
35.46 km from city center
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the breakfast and the helpful ...
Days Inn by Wyndham Florence Near Civic Center

Days Inn by Wyndham Florence Near Civic Center

140 Dunbarton Dr Florence SC
36.3 km from city center
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
SpringHill Suites by Marriott Florence

SpringHill Suites by Marriott Florence

2670 Hospitality Blvd Florence SC
35.65 km from city center
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the helpful staff and the clean ...
Quality Inn & Suites Florence Civic Center

Quality Inn & Suites Florence Civic Center

150 Dunbarton Dr Florence SC
36.35 km from city center
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
Hampton Inn & Suites Florence Center

Hampton Inn & Suites Florence Center

3000 W Radio Dr Florence SC
36.2 km from city center
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
TownePlace Suites by Marriott Florence

TownePlace Suites by Marriott Florence

2650 Hospitality Boulevard Florence SC
35.63 km from city center
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, a 24-hour fitness center, and parking (surcharge). Our guests praise the helpful ...
Florence Inn and Suites

Florence Inn and Suites

3821 Bancroft Rd Florence SC
33.16 km from city center
Stay at this hotel in Florence. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Florence Rail Trail and Regal Swamp Fox are located ...
Aloft by Marriott Florence

Aloft by Marriott Florence

820 WOODY JONES BOULEVARD Florence SC
35.43 km from city center
Book a stay at this business-friendly hotel in Florence. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Popular attractions Regal Swamp ...
Staybridge Suites Florence - Civic Center by IHG

Staybridge Suites Florence - Civic Center by IHG

150 Westpark Drive Florence SC
35.79 km from city center
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr by IHG

Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr by IHG

3440 W Radio Dr Florence SC
35.81 km from city center
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
Hilton Garden Inn Florence

Hilton Garden Inn Florence

2671 Hospitality Boulevard Florence SC
35.75 km from city center
Book a stay at this family-friendly hotel in Florence. Enjoy free parking, breakfast (surcharge), and room service. Our guests praise the helpful staff in our ...
Home2 Suites by Hilton Florence, SC

Home2 Suites by Hilton Florence, SC

900 Woody Jones Blvd Florence SC
35.51 km from city center
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
Don't see what you're looking for?
See all available properties in Lake City
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.