Business Hotels in Florence 2026
Featured Florence Business Hotels
Best Western Plus Tuscumbia Muscle Shoals Hotel and Suites
1934 Highway 20 Tuscumbia AL
Fully refundableReserve now, pay when you stay
Baymont by Wyndham Florence/Muscle Shoals
115 Ana Drive Florence AL
Best Western Plus Russellville Hotel & Suites
13770 Highway 43 Russellville AL
Fully refundableReserve now, pay when you stay
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Comfort Suites Florence Shoals Area
140 Matthew Paul Ct Florence AL
Microtel Inn & Suites by Wyndham Tuscumbia/Muscle Shoals
1852 Highway 72 E Tuscumbia AL
Clarion Inn Sheffield Muscle Shoals
4900 Hatch Blvd Sheffield AL
Hampton Inn & Suites Florence-Downtown
505 S Court St Florence AL
Fully refundableReserve now, pay when you stay
Hampton Inn Florence Midtown near University of North Alabama
2281 Florence Blvd Florence AL
Fully refundableReserve now, pay when you stay
Holiday Inn Express Hotel & Suites FLORENCE NORTHEAST by IHG
180 Etta Gray Street Florence AL
Fully refundable
Renaissance Shoals Resort and Spa
10 Hightower Place Florence AL
Fully refundableReserve now, pay when you stay
Americas Best Value Inn
14184 Highway 43 Russellville AL
Econo Lodge Russellville
13600 Highway 43 Russellville AL
Residence Inn Florence Marriott
1000 Sweetwater Ave Florence AL
Fully refundableReserve now, pay when you stay
The ColdWater Inn
712 Hwy 72 W Tuscumbia AL
Quality Inn Florence Muscle Shoals
150 Etta Gray Drive Florence AL
Lake View Inn & Suites
101 Highway 72 Killen AL
Comfort Inn & Suites Tuscumbia - Muscle Shoals
5101 Hwy 43 S Tuscumbia AL
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.