Downtown Vacation Packages for 2025

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Downtown Flight + Hotel packages

Price found within the past 48 hours. Click for updated prices.
Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

3.5 out of 5
per person
Aug 7 - Aug 13
found 14 hours ago
Roundtrip non-stop flight included
St. Louis (STL) to Greenville (GSP)
Stay at this 3.5-star business-friendly hotel in Greenville. Enjoy free WiFi, free parking, and 2 restaurants. Our guests praise the helpful staff and the room service in our reviews. Popular attractions Haywood Mall and Bon Secours Wellness Arena are located nearby.

La Quinta Inn & Suites by Wyndham Greenville Haywood

La Quinta Inn & Suites by Wyndham Greenville Haywood

3 out of 5
per person
Aug 7 - Aug 13
found 14 hours ago
Roundtrip non-stop flight included
St. Louis (STL) to Greenville (GSP)
Stay at this 3-star hotel in Greenville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Haywood Mall and Bon Secours Wellness Arena are located nearby.

Residence Inn by Marriott Greenville-Spartanburg Airport

Residence Inn by Marriott Greenville-Spartanburg Airport

3 out of 5
per person
Aug 7 - Aug 13
found 14 hours ago
Roundtrip non-stop flight included
St. Louis (STL) to Greenville (GSP)
Stay at this 3-star business-friendly hotel in Greenville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Haywood Mall and BMW Performance Center are located nearby.

Hotel Hartness

Hotel Hartness

4 out of 5
per person
Aug 7 - Aug 13
found 14 hours ago
Roundtrip non-stop flight included
St. Louis (STL) to Greenville (GSP)
Stay at this 4-star spa hotel in Greenville. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Haywood Mall and BMW Performance Center are located nearby.

Holiday Inn Greenville - Woodruff Road by IHG

Holiday Inn Greenville - Woodruff Road by IHG

3 out of 5
per person
Aug 7 - Aug 13
found 14 hours ago
Roundtrip non-stop flight included
St. Louis (STL) to Greenville (GSP)
Stay at this 3-star business-friendly hotel in Greenville. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff in our reviews. Popular attractions Haywood Mall and Bon Secours Wellness Arena are located nearby.

Comfort Inn Greenville - Haywood Mall

Comfort Inn Greenville - Haywood Mall

2.5 out of 5
per person
Aug 7 - Aug 13
found 14 hours ago
Roundtrip non-stop flight included
St. Louis (STL) to Greenville (GSP)
Book a stay at this business-friendly hotel in Greenville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Haywood Mall and Bon Secours Wellness Arena are located nearby.

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Top Hotel Deals

Quality Inn Seneca US-123

Quality Inn Seneca US-123

2.5 out of 5
226 Hi Tech Rd, Seneca, SC
0.59 km from Downtown
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
Best Western Plus Clemson Hotel & Conference Center

Best Western Plus Clemson Hotel & Conference Center

2.5 out of 5
1310 Tiger Blvd, Clemson, SC
11.78 km from Downtown
Book a stay at this business-friendly hotel in Clemson. Enjoy free parking, an outdoor pool, and a 24-hour fitness center. Our guests praise the helpful staff ...
Days Inn by Wyndham Anderson

Days Inn by Wyndham Anderson

2 out of 5
1007 George Smith Mill Rd, Anderson, SC
25.64 km from Downtown
Book a stay at this business-friendly motel in Anderson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson

4 out of 5
110 Sloan St, Clemson, SC
10.61 km from Downtown
Stay at this 4-star hotel in Clemson. Enjoy free WiFi, breakfast (surcharge), and valet parking (surcharge). Our guests praise the helpful staff and the clean ...
Lakeside Lodge Clemson

Lakeside Lodge Clemson

2.5 out of 5
13500 Clemson Blvd, Seneca, SC
8.58 km from Downtown
Stay at this hotel in Seneca. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
Wooded Cottage - 3 Mi to Clemson University

Wooded Cottage - 3 Mi to Clemson University

3 out of 5
12.41 km from Downtown
Stay at this 3-star cottage in Clemson. Enjoy free parking and air conditioning. Popular attractions Clemson Area African American Museum and Larry W. Abernathy ...
Inn @ Clemson

Inn @ Clemson

2.5 out of 5
1303 Tiger Blvd, Clemson, SC
11.64 km from Downtown
Book a stay at this business-friendly hotel in Clemson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
Comfort Inn & Suites Clemson - University Area

Comfort Inn & Suites Clemson - University Area

2.5 out of 5
1305 Tiger Blvd, Clemson, SC
11.67 km from Downtown
Book a stay at this business-friendly hotel in Clemson. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the helpful staff and the ...
The Inn at Patrick Square

The Inn at Patrick Square

3.5 out of 5
115 Market Street, Clemson, SC
15.23 km from Downtown
Stay at this 3.5-star hotel in Clemson. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our ...
Holiday Inn Express & Suites Clemson by IHG

Holiday Inn Express & Suites Clemson by IHG

2.5 out of 5
1381 Tiger Blvd, Clemson, SC
12.42 km from Downtown
Book a stay at this business-friendly hotel in Clemson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson

2.5 out of 5
13050 Clemson Blvd, Seneca, SC
8.33 km from Downtown
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
Microtel Inn & Suites by Wyndham Anderson/Clemson

Microtel Inn & Suites by Wyndham Anderson/Clemson

2 out of 5
102 Electric City Blvd, Anderson, SC
24.8 km from Downtown
Book a stay at this business-friendly hotel in Anderson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
Holiday Inn Express Hotel & Suites Anderson-I-85 by IHG

Holiday Inn Express Hotel & Suites Anderson-I-85 by IHG

2.5 out of 5
107 Interstate Blvd, Anderson, SC
24.97 km from Downtown
Book a stay at this business-friendly hotel in Anderson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area

2.5 out of 5
800 BYPASS 123, Seneca, SC
2.01 km from Downtown
Book a stay at this business-friendly hotel in Seneca. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the helpful staff in our reviews. ...
Hampton Inn & Suites Lavonia

Hampton Inn & Suites Lavonia

2.5 out of 5
115 Owens Drive, Lavonia, GA
30.72 km from Downtown
Book a stay at this business-friendly hotel in Lavonia. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Flight Deals

These prices were available within the past 7 days. Prices quoted are per person, round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Fri, Jul 4 - Sat, Jul 12
ORD
O'Hare Intl.
GSP
Greenville-Spartanburg Intl.
$195 Roundtrip, found 23 hours ago
$195
Roundtrip
found 23 hours ago
Select American Airlines flight, departing Fri, Jul 4 from O'Hare Intl. to Greenville-Spartanburg Intl., returning Sat, Jul 12, priced at $195 found 23 hours ago
Delta
Sun, Jun 15 - Sun, Jun 22
LGA
LaGuardia
GSP
Greenville-Spartanburg Intl.
$209 Roundtrip, found 5 days ago
$209
Roundtrip
found 5 days ago
Select Delta flight, departing Sun, Jun 15 from LaGuardia to Greenville-Spartanburg Intl., returning Sun, Jun 22, priced at $209 found 5 days ago
United
Tue, Jul 29 - Tue, Aug 5
DFW
Dallas-Fort Worth Intl.
GSP
Greenville-Spartanburg Intl.
$279 Roundtrip, found 2 days ago
$279
Roundtrip
found 2 days ago
Select United flight, departing Tue, Jul 29 from Dallas-Fort Worth Intl. to Greenville-Spartanburg Intl., returning Tue, Aug 5, priced at $279 found 2 days ago
Delta
Tue, Jul 29 - Tue, Aug 5
DAL
Love Field
GSP
Greenville-Spartanburg Intl.
$401 Roundtrip, found 2 days ago
$401
Roundtrip
found 2 days ago
Select Delta flight, departing Tue, Jul 29 from Love Field to Greenville-Spartanburg Intl., returning Tue, Aug 5, priced at $401 found 2 days ago