2026 5 Star Hotels in Santa Maria Novella

Choose two or more items and save on your trip:

Featured Santa Maria Novella 5 Star Hotels

W Florence

W Florence

5 out of 5
Piazza Dell'Unita Italiana 3/4 Florence FI
Fully refundableReserve now, pay when you stay
W Florence
The St. Regis Florence

The St. Regis Florence

5 out of 5
Piazza Ognissanti 1 Florence FI
Fully refundableReserve now, pay when you stay
The St. Regis Florence
The Excelsior, a Luxury Collection Hotel, Florence

The Excelsior, a Luxury Collection Hotel, Florence

5 out of 5
Piazza Ognissanti 3 Florence FI
Fully refundableReserve now, pay when you stay
The Excelsior, a Luxury Collection Hotel, Florence
Dimora Palanca Boutique & SPA

Dimora Palanca Boutique & SPA

5 out of 5
Via della Scala, 72 Florence FI
Fully refundableReserve now, pay when you stay
Dimora Palanca Boutique & SPA
Sina Villa Medici, Autograph Collection

Sina Villa Medici, Autograph Collection

5 out of 5
Via Il Prato 42 Florence FI
Fully refundableReserve now, pay when you stay
Sina Villa Medici, Autograph Collection
Anglo American Hotel Florence, Curio Collection by Hilton

Anglo American Hotel Florence, Curio Collection by Hilton

5 out of 5
Via Solferino, 6 Florence FI
Fully refundableReserve now, pay when you stay
Anglo American Hotel Florence, Curio Collection by Hilton
See all 822 properties in Santa Maria Novella
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.