2025 5 Star Hotels in Santa Maria Novella

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Featured Santa Maria Novella 5 Star Hotels

Anglo American Hotel Florence, Curio Collection by Hilton

Anglo American Hotel Florence, Curio Collection by Hilton

5 out of 5
Via Solferino, 6, Florence, FI
Anglo American Hotel Florence, Curio Collection by Hilton
The St. Regis Florence

The St. Regis Florence

5 out of 5
Piazza Ognissanti 1, Florence, FI
Fully refundableReserve now, pay when you stay
The St. Regis Florence
Sina Villa Medici, Autograph Collection

Sina Villa Medici, Autograph Collection

5 out of 5
Via Il Prato 42, Florence, FI
Fully refundableReserve now, pay when you stay
Sina Villa Medici, Autograph Collection
Dimora Palanca Boutique & SPA

Dimora Palanca Boutique & SPA

5 out of 5
Via della Scala, 72, Florence, FI
Dimora Palanca Boutique & SPA
The Excelsior, a Luxury Collection Hotel, Florence

The Excelsior, a Luxury Collection Hotel, Florence

5 out of 5
Piazza Ognissanti 3, Florence, FI
The Excelsior, a Luxury Collection Hotel, Florence
See all 739 properties in Santa Maria Novella
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.