2025 5 Star Hotels in Santa Cruz

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Featured Santa Cruz 5 Star Hotels

Hotel Alfonso XIII, a Luxury Collection Hotel, Seville

Hotel Alfonso XIII, a Luxury Collection Hotel, Seville

5 out of 5
San Fernando 2 Seville Seville
Fully refundableReserve now, pay when you stay
Hotel Alfonso XIII, a Luxury Collection Hotel, Seville
EME Catedral Mercer Hotel

EME Catedral Mercer Hotel

5 out of 5
Calle Alemanes 27 Seville Seville
Fully refundableReserve now, pay when you stay
EME Catedral Mercer Hotel
See all 437 properties in Santa Cruz
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.