2026 2 Star Hotels in Uptown

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Featured Uptown 2 Star Hotels

Tru By Hilton St. Louis Downtown

Tru By Hilton St. Louis Downtown

2.5 out of 5
1221 Locus Street St. Louis MO
Fully refundableReserve now, pay when you stay
Tru By Hilton St. Louis Downtown
The West End

The West End

2 out of 5
4215 Lindell Blvd St. Louis MO
Fully refundableReserve now, pay when you stay
The West End
Red Roof Inn PLUS+ St Louis - Forest Park/ Hampton Ave 

Red Roof Inn PLUS+ St Louis - Forest Park/ Hampton Ave 

2.5 out of 5
5823 Wilson Avenue St. Louis MO
Fully refundableReserve now, pay when you stay
Red Roof Inn PLUS+ St Louis - Forest Park/ Hampton Ave 
Best Western St. Louis Fairview Heights

Best Western St. Louis Fairview Heights

2.5 out of 5
150 Ludwig Dr Fairview Heights IL
Best Western St. Louis Fairview Heights
Days Inn by Wyndham Downtown St. Louis

Days Inn by Wyndham Downtown St. Louis

2 out of 5
2810 N 9th St St. Louis MO
Days Inn by Wyndham Downtown St. Louis
The Knight Center at Washington University

The Knight Center at Washington University

2.5 out of 5
Throop Drive and Snow Way St. Louis MO
Fully refundableReserve now, pay when you stay
The Knight Center at Washington University
Super 8 by Wyndham O'Fallon

Super 8 by Wyndham O'Fallon

2 out of 5
1100 Eastgate Dr O'Fallon IL
Super 8 by Wyndham O'Fallon
AC Hotel St. Louis Clayton

AC Hotel St. Louis Clayton

2 out of 5
227 South Central Ave St. Louis MO
Fully refundableReserve now, pay when you stay
AC Hotel St. Louis Clayton
Motel 6 Caseyville, IL - Caseyville Il

Motel 6 Caseyville, IL - Caseyville Il

2 out of 5
2431 Old Country Inn Dr Caseyville IL
Motel 6 Caseyville, IL - Caseyville Il
See all 1,588 properties in Uptown
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.