Flights from Chicago to Upstate South Carolina

Cheapest flights from Chicago

These prices were available within the past 7 days. Prices quoted are per person, round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Fri, Jul 4 - Sat, Jul 12

ORD

O'Hare Intl.

GSP

Greenville-Spartanburg Intl.

$195 Roundtrip, found 2 days ago

$195

Roundtrip

found 2 days ago

Select American Airlines flight, departing Fri, Jul 4 from O'Hare Intl. to Greenville-Spartanburg Intl., returning Sat, Jul 12, priced at $195 found 2 days ago

Fri, Jul 4 - Sat, Jul 12

ORD

O'Hare Intl.

GSP

Greenville-Spartanburg Intl.

$195 Roundtrip, found 2 days ago

$195

Roundtrip

found 2 days ago

Select United flight, departing Fri, Jul 4 from O'Hare Intl. to Greenville-Spartanburg Intl., returning Sat, Jul 12, priced at $195 found 2 days ago

Fri, Jul 4 - Sat, Jul 12

ORD

O'Hare Intl.

GSP

Greenville-Spartanburg Intl.

$202 Roundtrip, found 2 days ago

$202

Roundtrip

found 2 days ago

Select American Airlines flight, departing Fri, Jul 4 from O'Hare Intl. to Greenville-Spartanburg Intl., returning Sat, Jul 12, priced at $202 found 2 days ago

Fri, Jul 4 - Sat, Jul 12

ORD

O'Hare Intl.

GSP

Greenville-Spartanburg Intl.

$205 Roundtrip, found 2 days ago

$205

Roundtrip

found 2 days ago

Select United flight, departing Fri, Jul 4 from O'Hare Intl. to Greenville-Spartanburg Intl., returning Sat, Jul 12, priced at $205 found 2 days ago

Sat, Jul 19 - Wed, Jul 23

ORD

O'Hare Intl.

AVL

Asheville Regional

$207 Roundtrip, found 4 days ago

$207

Roundtrip

found 4 days ago

Select United flight, departing Sat, Jul 19 from O'Hare Intl. to Asheville Regional, returning Wed, Jul 23, priced at $207 found 4 days ago

Tue, Jul 1 - Wed, Jul 9

ORD

O'Hare Intl.

GSP

Greenville-Spartanburg Intl.

$215 Roundtrip, found 2 days ago

$215

Roundtrip

found 2 days ago

Select Delta flight, departing Tue, Jul 1 from O'Hare Intl. to Greenville-Spartanburg Intl., returning Wed, Jul 9, priced at $215 found 2 days ago

Fri, Jun 13 - Mon, Jun 23

ORD

O'Hare Intl.

GSP

Greenville-Spartanburg Intl.

$219 Roundtrip, found 20 hours ago

$219

Roundtrip

found 20 hours ago

Select American Airlines flight, departing Fri, Jun 13 from O'Hare Intl. to Greenville-Spartanburg Intl., returning Mon, Jun 23, priced at $219 found 20 hours ago

Mon, Jul 7 - Sat, Jul 12

ORD

O'Hare Intl.

GSP

Greenville-Spartanburg Intl.

$222 Roundtrip, found 2 days ago

$222

Roundtrip

found 2 days ago

Select Delta flight, departing Mon, Jul 7 from O'Hare Intl. to Greenville-Spartanburg Intl., returning Sat, Jul 12, priced at $222 found 2 days ago

Wed, Jul 16 - Tue, Jul 22

MDW

Midway Intl.

AVL

Asheville Regional

$227 Roundtrip, found 4 days ago

$227

Roundtrip

found 4 days ago

Select Delta flight, departing Wed, Jul 16 from Midway Intl. to Asheville Regional, returning Tue, Jul 22, priced at $227 found 4 days ago

Sat, Jul 19 - Sat, Jul 26

ORD

O'Hare Intl.

AVL

Asheville Regional

$227 Roundtrip, found 4 days ago

$227

Roundtrip

found 4 days ago

Select Delta flight, departing Sat, Jul 19 from O'Hare Intl. to Asheville Regional, returning Sat, Jul 26, priced at $227 found 4 days ago

Sat, Jul 19 - Thu, Jul 24

ORD

O'Hare Intl.

AVL

Asheville Regional

$228 Roundtrip, found 4 days ago

$228

Roundtrip

found 4 days ago

Select Delta flight, departing Sat, Jul 19 from O'Hare Intl. to Asheville Regional, returning Thu, Jul 24, priced at $228 found 4 days ago

Mon, Jul 7 - Sun, Jul 13

ORD

O'Hare Intl.

GSP

Greenville-Spartanburg Intl.

$229 Roundtrip, found 2 days ago

$229

Roundtrip

found 2 days ago

Select Delta flight, departing Mon, Jul 7 from O'Hare Intl. to Greenville-Spartanburg Intl., returning Sun, Jul 13, priced at $229 found 2 days ago

Fri, Jun 13 - Mon, Jun 23

ORD

O'Hare Intl.

GSP

Greenville-Spartanburg Intl.

$229 Roundtrip, found 20 hours ago

$229

Roundtrip

found 20 hours ago

Select United flight, departing Fri, Jun 13 from O'Hare Intl. to Greenville-Spartanburg Intl., returning Mon, Jun 23, priced at $229 found 20 hours ago

Sat, Jul 19 - Wed, Jul 23

ORD

O'Hare Intl.

AVL

Asheville Regional

$231 Roundtrip, found 4 days ago

$231

Roundtrip

found 4 days ago

Select United flight, departing Sat, Jul 19 from O'Hare Intl. to Asheville Regional, returning Wed, Jul 23, priced at $231 found 4 days ago

Sat, Jul 19 - Wed, Jul 23

ORD

O'Hare Intl.

AVL

Asheville Regional

$232 Roundtrip, found 4 days ago

$232

Roundtrip

found 4 days ago

Select United flight, departing Sat, Jul 19 from O'Hare Intl. to Asheville Regional, returning Wed, Jul 23, priced at $232 found 4 days ago

Fri, Jul 4 - Sat, Jul 12

ORD

O'Hare Intl.

GSP

Greenville-Spartanburg Intl.

$237 Roundtrip, found 2 days ago

$237

Roundtrip

found 2 days ago

Select Delta flight, departing Fri, Jul 4 from O'Hare Intl. to Greenville-Spartanburg Intl., returning Sat, Jul 12, priced at $237 found 2 days ago

Tue, Jun 10 - Sun, Jun 15

ORD

O'Hare Intl.

AVL

Asheville Regional

$239 Roundtrip, found 5 days ago

$239

Roundtrip

found 5 days ago

Select Delta flight, departing Tue, Jun 10 from O'Hare Intl. to Asheville Regional, returning Sun, Jun 15, priced at $239 found 5 days ago

Sat, Jul 19 - Wed, Jul 23

ORD

O'Hare Intl.

AVL

Asheville Regional

$241 Roundtrip, found 4 days ago

$241

Roundtrip

found 4 days ago

Select American Airlines flight, departing Sat, Jul 19 from O'Hare Intl. to Asheville Regional, returning Wed, Jul 23, priced at $241 found 4 days ago

Fri, Jul 4 - Sat, Jul 12

ORD

O'Hare Intl.

GSP

Greenville-Spartanburg Intl.

$242 Roundtrip, found 2 days ago

$242

Roundtrip

found 2 days ago

Select United flight, departing Fri, Jul 4 from O'Hare Intl. to Greenville-Spartanburg Intl., returning Sat, Jul 12, priced at $242 found 2 days ago

Fri, Jun 13 - Mon, Jun 23

MDW

Midway Intl.

GSP

Greenville-Spartanburg Intl.

$484 Roundtrip, found 20 hours ago

$484

Roundtrip

found 20 hours ago

Select Delta flight, departing Fri, Jun 13 from Midway Intl. to Greenville-Spartanburg Intl., returning Mon, Jun 23, priced at $484 found 20 hours ago