$221 Cheap Delta flights Detroit (DTW) to St. Louis (STL)

View $221 flight on Fri, Jan 23, 2026Opens in a new window

$221 Cheap Delta flights Detroit (DTW) to St. Louis (STL)

Prices were available within the past 7 days and start at $221 for one-way flights and $378 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Thu, Feb 26 - Fri, Mar 13
DTW
Detroit
STL
St. Louis
$378 Roundtrip, found 8 hours ago
$378
Roundtrip
found 8 hours ago
Select Delta flight, departing Thu, Feb 26 from Detroit to St. Louis, returning Fri, Mar 13, priced at $378 found 8 hours ago

Find the cheapest month to fly from Detroit (DTW) to St. Louis (STL)

October is typically the cheapest month to fly

From $60 - $312 per traveler.

Alternative airports near St. Louis

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Lambert-St. Louis Intl. STL. Cheapest option available. Average driving time to city center is 20 minutes. Flights from $155
STL
Lambert-St. Louis Intl.
Cheapest
Average driving time to city center20 min
Flights from $155
0
Flights from Detroit (DTW) to St. Louis (STL)
Origin airport
Detroit Metropolitan Wayne County
Destination airport
Lambert-St. Louis Intl.
Airlines serving
American Airlines, Delta, Frontier Airlines, Southwest Airlines, United
Popular airline
United
Distance
703 km