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Residence Inn Durham McPherson/Duke University Medical Cntr

Property class: 3

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Photo gallery for Residence Inn Durham McPherson/Duke University Medical Cntr

An outdoor patio with wicker furniture, a stone fire pit, and a brick building in the background. - Residence Inn Durham McPherson/Duke University Medical Cntr (Durham)
A multi-story brick building with a modern entrance and a parking lot. - Residence Inn Durham McPherson/Duke University Medical Cntr (Durham)
A gym with treadmills, elliptical machines, a bench press, and a blue balance board. - Residence Inn Durham McPherson/Duke University Medical Cntr (Durham)
A hotel room with two beds, a desk, a TV, and a sofa. - Residence Inn Durham McPherson/Duke University Medical Cntr (Durham)
A spacious lobby with a reception desk, seating area, and a beverage kiosk. - Residence Inn Durham McPherson/Duke University Medical Cntr (Durham)
You can look forward to free to-go breakfast, a free grocery shopping service, and a terrace at Residence Inn Durham McPherson/Duke University Medical Cntr. Free in-room WiFi is available to all guests, along with dry cleaning/laundry services and a fireplace in the lobby.

Reviews

9.2 out of 10
Wonderful

Popular amenities

  • Pet friendly
  • Free WiFi
  • Air conditioning

Off-peak, on budget: 30% or more off select hotels in our fall sale

Skip the crowds, keep the savings. AARP members save more after Labor Day. Book by Oct 7, 2026.

Room options

Available filters for rooms
Showing 10 of 10 rooms

View all photos for Suite, 1 Bedroom

32-inch Smart TV with cable channels, TV, Netflix

Suite, 1 Bedroom

8.8 out of 10
Excellent
(6 reviews)
  • 44 sq m
  • Sleeps 3
  • 1 King Bed and 1 Double Sofa Bed OR 1 Queen Bed

View all photos for Studio, 1 King Bed with Sofa bed

A modern hotel room with a bed, a desk, a chair, a television, and a small table.

Studio, 1 King Bed with Sofa bed

8.8 out of 10
Excellent
(38 reviews)
  • 45 sq m
  • 1 bedroom
  • Sleeps 3
  • 1 King Bed and 1 Double Sofa Bed

View all photos for Studio, 1 Queen Bed with Sofa bed

A modern hotel room with a bed, a TV, a kitchenette, and a dining area.

Studio, 1 Queen Bed with Sofa bed

9.8 out of 10
Exceptional
(16 reviews)
  • 39 sq m
  • Sleeps 3
  • 1 Queen Bed and 1 Double Sofa Bed

View all photos for Suite, 1 Bedroom (Hearing Accessible)

A hotel room with a bed, a desk, a chair, and a TV.

Suite, 1 Bedroom (Hearing Accessible)

8.8 out of 10
Excellent
(3 reviews)
  • 1 bedroom
  • Sleeps 3
  • 1 King Bed and 1 Double Sofa Bed OR 1 Queen Bed

View all photos for Studio, 1 King Bed with Sofa bed (Mobility/Hearing Accessible, Tub)

A modern hotel room with a bed, a desk, a chair, a television, and a small table.

Studio, 1 King Bed with Sofa bed (Mobility/Hearing Accessible, Tub)

10.0 out of 10
Exceptional
(2 reviews)
  • 44 sq m
  • 1 bedroom
  • Sleeps 3
  • 1 King Bed and 1 Double Sofa Bed

View all photos for Studio, 1 King Bed with Sofa bed (Mobility Accessible, Tub)

A modern hotel room with a bed, a desk, a chair, a television, and a small table.

Studio, 1 King Bed with Sofa bed (Mobility Accessible, Tub)

  • 45 sq m
  • 1 bedroom
  • Sleeps 3
  • 1 King Bed and 1 Double Sofa Bed

View all photos for Studio, 1 King Bed with Sofa bed (Hearing Accessible)

A modern hotel room with a bed, a desk, a chair, a television, and a small table.

Studio, 1 King Bed with Sofa bed (Hearing Accessible)

  • 45 sq m
  • 1 bedroom
  • Sleeps 3
  • 1 King Bed and 1 Double Sofa Bed

View all photos for Studio, 1 Queen Bed with Sofa bed (Hearing Accessible)

A hotel room with a bed, a desk, a chair, and a TV.

Studio, 1 Queen Bed with Sofa bed (Hearing Accessible)

  • 40 sq m
  • Sleeps 3
  • 1 Queen Bed and 1 Double Sofa Bed

View all photos for Suite, Multiple Beds (Mobility Accessible, Tub)

A hotel room with two beds, a flat-screen TV mounted on the wall, a wooden headboard, and a window with sheer curtains.

Suite, Multiple Beds (Mobility Accessible, Tub)

8.0 out of 10
Very good
(3 reviews)
  • 1 bedroom
  • Sleeps 5
  • 2 Queen Beds and 1 Double Sofa Bed

View all photos for Suite, 1 Bedroom (Mobility Accessible, Roll-in Shower)

A hotel room with a bed, a desk, a chair, and a TV.

Suite, 1 Bedroom (Mobility Accessible, Roll-in Shower)

10.0 out of 10
Exceptional
(1 review)
  • 1 bedroom
  • Sleeps 3
  • 1 King Bed and 1 Double Sofa Bed OR 1 Queen Bed

About the neighborhood

Located in Trinity Park, a neighborhood in Durham, Residence Inn Durham McPherson/Duke University Medical Cntr is near a train station. Travelers who have shopping on the agenda can visit Streets at Southpoint Mall and Brier Creek Commons. Durham Performing Arts Center and Sarah P. Duke Gardens are also worth visiting. Visit our Durham travel guide
Map
1108 West Main Street, Durham, NC, 27701

What's nearby

  • A cobblestone street lined with brick buildings, benches, and trees.
    Brightleaf Square
    3 min walk - 0.2 miles
  • A large Gothic-style cathedral with intricate stonework and multiple spires.
    Duke University
    3 min walk - 0.2 miles
  • Durham Convention Center
    12 min walk - 0.7 miles
  • Carolina Theatre
    12 min walk - 0.7 miles
  • Durham Performing Arts Center
    16 min walk - 0.9 miles

Getting around

  • Durham Station
    8 min walk
  • Raleigh-Durham International Airport (RDU)
    21 min drive

Restaurants

  • Grub Durham
    12 min walk
  • Dakine's Kava
    11 min walk
  • The Federal
    3 min walk
  • Atomic Clock Brewing Co
    11 min walk
  • Emmy Squared
    5 min walk

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Property amenities

Internet

  • Available in all rooms: Free WiFi
  • Available in some public areas: Free WiFi

Parking and transportation

  • Free area shuttle
  • Self parking on site (USD 15 per day)
  • Wheelchair-accessible parking available

Food and drink

  • Free on-the-go breakfast available daily 7:00 AM to 9:00 AM
  • Coffee and tea in common areas

Things to do

  • 24-hour gym

Family friendly

  • Dining table
  • Free area shuttle
  • Grocery/convenience store
  • In-room full-sized refrigerator/freezer
  • In-room kitchen
  • In-room microwave
  • Laundry facilities

Conveniences

  • 24-hour front desk
  • Free newspapers in lobby
  • Grocery/convenience store
  • Laundry facilities
  • Luggage storage
  • Safe at front desk

Guest services

  • Change of bedsheets (on request)
  • Change of towels on request
  • Concierge services
  • Dry cleaning/laundry service
  • Free grocery shopping service
  • Housekeeping (daily)
  • Wedding services

Business services

  • 2,530 square feet of conference space
  • Business center
  • Computer station

Outdoors

  • Terrace

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • 7 on-site accessible parking spaces
  • Assistive listening devices in meeting rooms
  • Braille/raised signage
  • Elevator (42 inch wide door)
  • Hardwood flooring in room
  • Lever door handles
  • Thin carpet in room
  • Visual alarms in hallways
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible business center
  • Wheelchair-accessible gym
  • Wheelchair-accessible lounge
  • Wheelchair-accessible parking
  • Wheelchair-accessible path of travel
  • Wheelchair-accessible path to elevator
  • Wheelchair-accessible registration desk (34 inches high)
  • Wheelchair-accessible restaurant

More

  • 5 floors
  • Banquet hall
  • Built in 2015
  • Double-glazed windows
  • Fireplace in lobby
  • No plastic coffee stirrers
  • No plastic drinking straws
  • Non-plastic coffee stirrers available
  • Renovated entire property - April 2024
  • Smoking not allowed
  • Vegan dining options
  • Vegetarian breakfast available
  • Vegetarian dining options

Room amenities

Bedroom

  • Bedsheets provided
  • Blackout drapes

Bathroom

  • Free toiletries
  • Hair dryer
  • Shower/bathtub combination
  • Towels provided

Entertainment

  • 32-inch smart TV with premium cable channels
  • Netflix
  • Pay movies

Food and drink

  • Coffee/tea maker
  • Cookware, dishware, and utensils
  • Dining table
  • Dishwasher
  • Full-sized refrigerator/freezer
  • Kitchen
  • Microwave
  • Stovetop

More

  • Air conditioning (climate-controlled)
  • Desk
  • Desk chair
  • Free local calls
  • Iron/ironing board
  • Laptop workspace
  • LED lighting
  • Phone
  • Recycling
  • Safe
  • Separate sitting area
  • Water-efficient showers

Policies

Check-in

Check-in start time: 3 PM; Check-in end time: midnight
Express check-in available
Minimum check-in age: 21

Check-out

Check-out before noon
Contactless check-out available
Express check-out available

Special check-in instructions

Front desk staff will greet guests on arrival at the property
Information provided by the property may be translated using automated translation tools

Access methods

Staffed front desk

Pets

Pets allowed for an extra charge of USD 100.00 per pet (varies based on length of stay)
Service animals are welcome, and are exempt from fees
2 total (up to 100 lbs per pet)
Restrictions apply; for more information contact the property at the number on the booking confirmation

Children and extra beds

Children are welcome
Rollaway/extra beds are not available
Cribs (infant beds) are not available

Property payment types

American ExpressDiners ClubDiscoverJCB InternationalMastercardVisa

Important information

Optional extras

  • Self parking fee: USD 15 per day
  • Pet fee: USD 100.00 per pet (varies based on length of stay)
  • Service animals are exempt from fees

The above list may not be comprehensive. Fees and deposits may not include tax and are subject to change.

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
This property accepts credit cards; cash is not accepted
Safety features at this property include a carbon monoxide detector, a fire extinguisher, and a smoke detector

We should mention

Guests under 18 years old are not allowed in the fitness facility, and guests under 18 years old are only allowed in the swimming pool and fitness facility with adult supervision
This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly)

Frequently asked questions

Is Residence Inn Durham McPherson/Duke University Medical Cntr pet-friendly?

Yes, Residence Inn Durham McPherson/Duke University Medical Cntr allows pets (limit 2 total) with a maximum weight of up to 100 lbs per pet. There's a fee of USD 100.00 per pet, per stay. Service animals are exempt from fees. Some restrictions may apply, so please contact the property for more details.

How much is parking?

Self parking is available for USD 15 per day.

What time is check-in at Residence Inn Durham McPherson/Duke University Medical Cntr?

Check-in start time: 3 PM; Check-in end time: midnight.

What time is check-out at Residence Inn Durham McPherson/Duke University Medical Cntr?

Check-out is at noon.

Where is Residence Inn Durham McPherson/Duke University Medical Cntr located?

Located in Trinity Park, this hotel is within 1 mi (2 km) of Brightleaf Square and Duke University. North Carolina Mutual Life Insurance and Carolina Theatre are also within 15 minutes. Durham Station is 8 minutes by foot.

Can I cancel my reservation for free and receive a full refund?

Yes, this property offers free cancellation on select room rates, because flexibility matters! Please refer to the property cancellation policy on our site for more details about any exclusions or requirements.

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Reviews

Residence Inn Durham McPherson/Duke University Medical Cntr Reviews

9.2

Wonderful

9.4

Cleanliness

9.0

Location

9.4

Staff & service

9.2

Property conditions & facilities
Rating 10 - Excellent. 336 out of 500 reviews
Rating 8 - Good. 113 out of 500 reviews
Rating 6 - Okay. 31 out of 500 reviews
Rating 4 - Poor. 8 out of 500 reviews
Rating 2 - Terrible. 12 out of 500 reviews

Reviews

Verified review

10/10 Excellent

MOHAMMAD AAMIR

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Shuttle service within 3 mile radius was really helpful. Both the drivers Brad and Kayla, were friendly and always ready to help. 1000/10 for them.
Stayed 13 nights in Jul 2026
Verified review

10/10 Excellent

Shelly

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Room was very spacious, staff very friendly
Stayed 1 night in May 2026
Verified review

8/10 Good

Sarah

Liked: Cleanliness, staff & service, amenities
Room was clean. Comfortable bed. Basic hotel breakfast. Lots of parking. Had A/C issue quickly resolved by a really nice technician. Close to 9th St where there’s lots of restaurants. Vin Rouge was delicious and JuJu. Would stay here again.
Stayed 2 nights in Jul 2026
Verified review

10/10 Excellent

Tiffany

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Clean, spacious rooms with an extremely helpful staff! Highly recommended!!
Stayed 3 nights in Apr 2026
Verified review

10/10 Excellent

Jeff

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Very clean and spacious room. Hotel staff that I had contact with were very hospitable and professional.
Stayed 1 night in May 2026
Verified review

10/10 Excellent

RICHARD

Liked: Cleanliness, staff & service, property conditions & facilities
Great downtown location
Stayed 1 night in Mar 2026
Verified review

10/10 Excellent

Diana

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The rooms are spacious and the location is great in downtown Durham. Easy walk to Duke east. Several good restaurants and ice cream are just a block away. There's a charge for parking here. Breakfast was tasty. I would stay here again.
Stayed 2 nights in May 2026
Verified review

8/10 Good

Robert

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Excellent breakfast. The staff was outstanding. The room's television did not work the first night and the front desk clerk spent extensive time troubleshooting and escalating the outage. The room's heating, cooling and fan did not respond to the in-room thermostat.
Stayed 2 nights in Jul 2026
Verified review

6/10 Okay

Irena

Liked: Staff & service
Disliked: Amenities
Good location. Poorly designed rooms. Poor cleaning. Good breakfast. Good parking. Efficient staff -Daniasia was very helpful.
Stayed 4 nights in Jun 2026
Verified review

10/10 Excellent

Anna F

Liked: Cleanliness, amenities, property conditions & facilities
Courteous staff, spotless rooms, comfortable bed and pillows.
Stayed 4 nights in Dec 2025
Verified review

10/10 Excellent

Lisa

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Hotel was great - very friendly staff.
Stayed 2 nights in Sep 2025
Verified review

8/10 Good

Vincent

Liked: Cleanliness, staff & service, property conditions & facilities
Overall it was a decent and very nice review 54 stars because the hotel was so clean and nice. Vincent Jackson room 322.hotel, the breakfast was very good and everyone was pleasant and friendly; however, I found the mattress in my room to be hard and uncomfortable, after talking to staff they put a softer cover on the bed that helped some but that wasn't until the last night of a 3 night stay.theere was no hot water in my room for the entire stay,I had to revert back to my old military days and wash accordingly. I let the hotel receptionist know of this many times but nothing was ever done about it. Iwas surprised because I never experienced this ever at a residence inn anywhere before. I was not offered any room rate reduction or compensation, I found this to be a bit strange. I still give a 4 star re irw
Stayed 3 nights in Aug 2026
Verified review

10/10 Excellent

David

Liked: Cleanliness, staff & service, amenities
We love this hotel. The staff is excellent and the rooms are well designed and comfortable. The breakfast is delicious.
Stayed 10 nights in Dec 2025
Verified review

10/10 Excellent

Athena

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
I had a great stay overall. The service was excellent, and the staff was incredibly friendly, welcoming, and helpful throughout my visit. They really made the experience enjoyable. Rooms are spacious and beds are comfortable. The only area that could use improvement is the breakfast. The selection was very basic, mostly eggs and pork options, with limited healthier choices available. The fruit also did not seem very fresh. I think revamping the breakfast menu with fresher ingredients and more healthy variety would make the stay even better. Despite that, I would still recommend this hotel because the customer service was outstanding.
Stayed 1 night in May 2026
Verified review

10/10 Excellent

Judy

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Great location with some incredible Restaurants nearby
Stayed 3 nights in Oct 2024
Verified review

10/10 Excellent

Margaret

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Great and reasonably priced place to stay as a family in the center of Durham.
Stayed 1 night in Sep 2024
Verified review

10/10 Excellent

Tim

Liked: Cleanliness, staff & service, amenities
Great stay. The hotel breakfast left a little something to be desired but the room was clean, the staff was helpful. This was everything I expected.
Stayed 2 nights in Nov 2025
Verified review

10/10 Excellent

Wendy

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Clean, friendly, great location.
Stayed 1 night in Sep 2024
Verified review

10/10 Excellent

Hong

Liked: Cleanliness, staff & service, property conditions & facilities
Nice staff, very helpful. Close to Duke University, great place to stay.
Stayed 6 nights in Jan 2025
Verified review

10/10 Excellent

Mustafa

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
comfortable stay
Stayed 3 nights in Nov 2023
Verified review

10/10 Excellent

LaMeesha

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
I am thankful for the very hospitable staff that I encountered at the hotel. Everyone was smiling at the front desk every time I passed by.
Stayed 8 nights in Jun 2025
Verified review

10/10 Excellent

Timothy

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Great location in Durham!
Stayed 1 night in Apr 2024
Verified review

8/10 Good

Heman

Liked: Cleanliness, amenities, property conditions & facilities
Laura and Tiffany were extremely helpful and accommodating. The whole staff was very friendly and welcoming!
Stayed 9 nights in Jul 2025
Verified review

10/10 Excellent

Kelly

Liked: Property conditions & facilities
Very nice staff and very clean!
Stayed 1 night in Feb 2024
Verified review

10/10 Excellent

Timmy

Liked: Cleanliness, amenities, property conditions & facilities
It was very clean and the staff was excellent. The stay was really good. The attendant was great at checking.
Stayed 1 night in Jun 2025