Skip to main content

Hilton Jacksonville At Mayo Clinic

4.5 star property
Luxury hotel with area shuttle service and a fitness center

Choose dates to view prices

A short walk from Mayo Clinic Florida, Hilton Jacksonville At Mayo Clinic provides a grocery/convenience store, a firepit, and dry cleaning/laundry services. The on-site American cuisine restaurant, Coastal Kitchen, offers breakfast, lunch, dinner, and kids' meals. Stay connected with free in-room WiFi, with speed of 25+ Mbps, and guests can find other amenities such as a bar and a gym.

Reviews

9.6 out of 10
Exceptional

Popular amenities

  • Breakfast available
  • Pool
  • Room service
  • Bar
  • Parking included
  • Gym

Room options

Available filters for rooms
Showing 20 of 20 rooms

View all photos for Room, 1 King Bed

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 1 King Bed

Highlights

Air conditioning
Heating
Free cribs/infant beds
Mini-fridge
Smart TV
Premium bedding
Blackout drapes/curtains
Hair dryer
  • Sleeps 2
  • 1 King Bed

View all photos for Deluxe Room, 1 King Bed (Water View)

View from room

Deluxe Room, 1 King Bed (Water View)

Highlights

Air conditioning
Heating
Free cribs/infant beds
Mini-fridge
Smart TV
Sofa bed - single
Premium bedding
Blackout drapes/curtains
  • Water view
  • Sleeps 2
  • 1 King Bed

View all photos for Deluxe Room, 1 King Bed, Accessible (Roll-In Shower)

View from room

Deluxe Room, 1 King Bed, Accessible (Roll-In Shower)

Highlights

Air conditioning
Heating
Free cribs/infant beds
Mini-fridge
Smart TV
Premium bedding
Blackout drapes/curtains
Hair dryer
  • Sleeps 2
  • 1 King Bed

View all photos for Junior Suite, 1 King Bed

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Junior Suite, 1 King Bed

Highlights

Air conditioning
Heating
Free cribs/infant beds
Mini-fridge
Smart TV
Sofa bed - single
Premium bedding
Blackout drapes/curtains
  • Sleeps 4
  • 1 King Bed

View all photos for Junior Suite, 1 King Bed, Corner

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Junior Suite, 1 King Bed, Corner

Highlights

Air conditioning
Heating
Free cribs/infant beds
Mini-fridge
Smart TV
Sofa bed - single
Premium bedding
Blackout drapes/curtains
  • Sleeps 4
  • 1 King Bed

View all photos for Junior Suite, 1 King Bed, Accessible (Roll-In Shower)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Junior Suite, 1 King Bed, Accessible (Roll-In Shower)

Highlights

Air conditioning
Heating
Free cribs/infant beds
Mini-fridge
Smart TV
Premium bedding
Blackout drapes/curtains
Hair dryer
  • Sleeps 2
  • 1 King Bed

View all photos for Junior Suite, 1 King Bed, Accessible (Roll-In Shower)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Junior Suite, 1 King Bed, Accessible (Roll-In Shower)

Highlights

Air conditioning
Heating
Free cribs/infant beds
Mini-fridge
Smart TV
Premium bedding
Blackout drapes/curtains
Hair dryer
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed, Accessible (Mobility & Hearing, Roll-In Shower)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Suite, 1 King Bed, Accessible (Mobility & Hearing, Roll-In Shower)

Highlights

Air conditioning
Heating
Free cribs/infant beds
Mini-fridge
Smart TV
Premium bedding
Blackout drapes/curtains
Hair dryer
  • Sleeps 2
  • 1 King Bed

View all photos for Room, 1 King Bed (Zero Count)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 1 King Bed (Zero Count)

Highlights

Air conditioning
Heating
Free cribs/infant beds
Mini-fridge
Smart TV
Premium bedding
Blackout drapes/curtains
Hair dryer
  • Sleeps 2
  • 1 King Bed

View all photos for Room, 1 King Bed (Water View)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 1 King Bed (Water View)

8.0 out of 10
Very good
(1 review)

Highlights

Air conditioning
Heating
Free cribs/infant beds
Mini-fridge
Smart TV
Premium bedding
Blackout drapes/curtains
Hair dryer
  • Water view
  • Sleeps 2
  • 1 King Bed

View all photos for Room, 1 King Bed (Water View, Roll-In Shower)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 1 King Bed (Water View, Roll-In Shower)

Highlights

Air conditioning
Heating
Free cribs/infant beds
Mini-fridge
Smart TV
Premium bedding
Blackout drapes/curtains
Hair dryer
  • Water view
  • Sleeps 2
  • 1 King Bed

View all photos for Room, 1 King Bed, Accessible (Hearing)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 1 King Bed, Accessible (Hearing)

Highlights

Air conditioning
Heating
Free cribs/infant beds
Mini-fridge
Smart TV
Premium bedding
Blackout drapes/curtains
Hair dryer
  • Sleeps 2
  • 1 King Bed

View all photos for Room, 1 King Bed, Accessible (Roll-In Shower)

Room, 1 King Bed, Accessible (Roll-In Shower) | Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 1 King Bed, Accessible (Roll-In Shower)

Highlights

Air conditioning
Heating
Free cribs/infant beds
Mini-fridge
Smart TV
Premium bedding
Blackout drapes/curtains
Hair dryer
  • Sleeps 2
  • 1 King Bed

View all photos for Room, 1 King Bed, Accessible (Hearing)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 1 King Bed, Accessible (Hearing)

Highlights

Air conditioning
Heating
Free cribs/infant beds
Mini-fridge
Smart TV
Premium bedding
Blackout drapes/curtains
Hair dryer
  • Sleeps 2
  • 1 King Bed

View all photos for Room, 2 Queen Beds

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 2 Queen Beds

9.8 out of 10
Exceptional
(6 reviews)

Highlights

Air conditioning
Heating
Free cribs/infant beds
Mini-fridge
Smart TV
Premium bedding
Blackout drapes/curtains
Hair dryer
  • Sleeps 4
  • 2 Queen Beds

View all photos for Room, 2 Queen Beds, Accessible (Water View, Hearing)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 2 Queen Beds, Accessible (Water View, Hearing)

Highlights

Air conditioning
Heating
Free cribs/infant beds
Mini-fridge
Smart TV
Premium bedding
Blackout drapes/curtains
Hair dryer
  • Water view
  • Sleeps 4
  • 2 Queen Beds

View all photos for Room, 2 Queen Beds, Accessible, Bathtub

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 2 Queen Beds, Accessible, Bathtub

Highlights

Air conditioning
Heating
Free cribs/infant beds
Mini-fridge
Smart TV
Premium bedding
Blackout drapes/curtains
Hair dryer
  • Sleeps 4
  • 2 Queen Beds

View all photos for Room, 2 Queen Beds, Accessible (Hearing)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 2 Queen Beds, Accessible (Hearing)

Highlights

Air conditioning
Heating
Free cribs/infant beds
Mini-fridge
Smart TV
Premium bedding
Blackout drapes/curtains
Hair dryer
  • Sleeps 4
  • 2 Queen Beds

View all photos for Room, 2 Queen Beds (Water View)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 2 Queen Beds (Water View)

Highlights

Air conditioning
Heating
Free cribs/infant beds
Mini-fridge
Smart TV
Premium bedding
Blackout drapes/curtains
Hair dryer
  • Water view
  • Sleeps 4
  • 2 Queen Beds

View all photos for Room, 2 Queen Beds, Accessible, Bathtub (View)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 2 Queen Beds, Accessible, Bathtub (View)

Highlights

Air conditioning
Heating
Free cribs/infant beds
Mini-fridge
Smart TV
Premium bedding
Blackout drapes/curtains
Hair dryer
  • Sleeps 4
  • 2 Queen Beds

You may also like

Ad
Indoor pool, 2 outdoor pools, cabanas (surcharge), pool umbrellas

Omni Amelia Island Resort & Spa

Fernandina Beach
  • Pool
  • Hot Tub
  • Spa
  • Pet friendly
8.8 out of 10, Excellent, 1,005 reviews
Omni Amelia Island Resort & Spa

About the neighborhood

Map
4745 Transformation Way, Jacksonville, FL, 32224

What's nearby

  • Mayo Clinic Florida - 1 min walk - 0.0 miles
  • University of North Florida - 5 min drive - 5.2 miles
  • St. Johns Town Center - 7 min drive - 6.8 miles
  • Mayport Naval Station - 17 min drive - 11.8 miles
  • Jacksonville Naval Air Station - 29 min drive - 29.2 miles

Getting around

  • Jacksonville Station - 28 min drive
  • Jacksonville International Airport (JAX) - 31 min drive

Restaurants

  • ‪Culver's #964 - ‬3 min drive
  • ‪M Brothers at Mayo - ‬14 min walk
  • ‪Starbucks - ‬3 min drive
  • ‪Circle K - ‬16 min walk
  • ‪Mayo Clinic - Employee Cafeteria - ‬14 min walk

About this property

Hilton Jacksonville At Mayo Clinic

Luxury hotel near St. Johns Town Center
A short walk from Mayo Clinic Florida, Hilton Jacksonville At Mayo Clinic provides a grocery/convenience store, a firepit, and dry cleaning/laundry services. The on-site American cuisine restaurant, Coastal Kitchen, offers breakfast, lunch, dinner, and kids' meals. In addition to a bar and a gym, guests can connect to free in-room WiFi, with speed of 25+ Mbps.
Other perks at this hotel include:
  • An outdoor pool along with sun loungers and pool umbrellas
  • Free self parking
  • Buffet breakfast (surcharge), a free area shuttle, and an electric car charging station
  • Express check-out, outdoor furniture, and smoke-free premises
Room features
All 252 rooms offer comforts such as premium bedding and laptop-compatible safes, as well as perks like late night room service and free WiFi.
Extra conveniences in all rooms include:
  • Recycling and LED light bulbs
  • Tubs or showers, hair dryers, and shampoo
  • 55-inch Smart TVs with Netflix, streaming services, and premium channels
  • Mini fridges, free infant beds, and coffee/tea makers

Similar properties

On the beach, white sand, surfing, kayaking
Margaritaville Jacksonville Beach
  • Pool
  • Free WiFi
  • Restaurant
  • Air conditioning
9.0 out of 10, Wonderful, 3,407 reviews
Margaritaville Jacksonville Beach

Property amenities

Internet

  • Available in all rooms: Free WiFi
  • In-room WiFi speed: 25+ Mbps
  • Available in some public areas: Free WiFi

Parking and transportation

  • Electric car charging station on site
  • Free area shuttle up to 350 yds
  • Free uncovered self parking on site

Food and drink

  • Daily buffet breakfast available 6:00 AM to 10:30 AM for a fee: USD 26.99 to 26.99 for adults and USD 15 to 21 for children
  • A bar/lounge
  • A restaurant

Restaurants on site

  • Coastal Kitchen
  • Coastal Kitchen Bar

Things to do

  • Gym
  • Outdoor pool
  • TV in common areas

Family friendly

  • Free area shuttle
  • Grocery/convenience store
  • In-room crib
  • Laundry facilities
  • Mini-fridge
  • Outdoor pool
  • Rollaway/extra bed (surcharge)

Conveniences

  • 24-hour front desk
  • Grocery/convenience store
  • Laundry facilities
  • Luggage storage

Guest services

  • Concierge services
  • Dry cleaning/laundry service
  • Housekeeping (daily)
  • Porter/bellhop
  • Proposal/romance packages
  • Wedding services

Business services

  • 12 meeting rooms
  • 20,000 square feet of conference space
  • Coworking space

Outdoors

  • Firepit
  • Outdoor furniture
  • Pool loungers
  • Pool umbrellas

Accessibility

  • Tile flooring in public areas

More

  • 1 building
  • 8 floors
  • At least 80% lighting from LEDs
  • At least 80% of food locally-sourced
  • Built in 2025
  • Comprehensive food waste policy
  • Smoking not allowed
  • Traditional architecture
  • Vegetarian breakfast available
  • Vegetarian dining options

Room amenities

Bedroom

  • Blackout drapes
  • Free crib
  • Premium bedding
  • Rollaway/extra bed (surcharge)

Bathroom

  • Bathtub or shower
  • Hair dryer
  • Shampoo
  • Soap
  • Toilet paper
  • Towels provided

Entertainment

  • 55-inch smart TV with premium cable channels
  • Netflix
  • Streaming services

Food and drink

  • Coffee/tea maker
  • Free bottled water
  • Late-night room service
  • Mini-fridge

More

  • Air conditioning
  • Free local calls
  • Free long-distance calls
  • Heating
  • Iron/ironing board
  • Laptop-compatible safe
  • LED lighting
  • Mobile key entry
  • Phone
  • Recycling
  • Water-efficient showers
  • Water-efficient toilets

Policies

Check-in

Check-in start time: 4:00 PM; Check-in end time: 5:00 AM
Late check-in subject to availability
Minimum check-in age: 21

Check-out

Check-out before 11:00 AM
Contactless check-out available
Express check-out available

Special check-in instructions

Front desk staff will greet guests on arrival at the property
If you are planning to arrive after 11:00 PM please contact the property in advance using the information on the booking confirmation
The credit card used to book the reservation must be presented by the cardholder at check-in along with matching photo identification, and other arrangements must be coordinated with the property prior to arrival
Information provided by the property may be translated using automated translation tools

Access methods

Staffed front desk

Pets

Pets not allowed

Children and extra beds

Children are welcome
2 children, per adult, up to the age of 18 years, can stay for free if using existing beds when occupying the parent or guardian's room
Rollaway/extra beds are available for USD 50.00 per night
Free cribs are available on request at the property

Property payment types

Important information

Fees

You'll be asked to pay the following charges at the property. Fees may include applicable taxes:

  • Breakage deposit: USD 100 per stay

We have included all charges provided to us by the property.

Optional extras

  • Fee for buffet breakfast: approximately USD 26.99 to 26.99 for adults, and USD 15 to 21 for children
  • Rollaway bed fee: USD 50.00 per night

The above list may not be comprehensive. Fees and deposits may not include tax and are subject to change.

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
The name on the credit card used at check-in to pay for incidentals must be the primary name on the guestroom reservation
This property accepts credit cards and debit cards; cash is not accepted
This property reserves the right to pre-authorize the guest's credit card prior to arrival.
Cashless transactions are available
Safety features at this property include a carbon monoxide detector and a smoke detector

We should mention

Pool access available from 8:00 AM to 10:00 PM
Only registered guests are allowed in the guestrooms
A car is not required for transportation to and from this property
Guests under 16 years old are not allowed in the fitness facility, and guests under 16 years old are only allowed in the swimming pool with adult supervision
This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly)

Property is also known as

Hilton Jacksonville At Mayo Clinic Hotel
Hilton Jacksonville At Mayo Clinic Jacksonville
Hilton Jacksonville At Mayo Clinic Hotel Jacksonville

Frequently asked questions

Does Hilton Jacksonville At Mayo Clinic have a pool?

Yes, this property has an outdoor pool. Pool access is from 8:00 AM–10:00 PM.

Is Hilton Jacksonville At Mayo Clinic pet-friendly?

No, pets are not allowed at this property.

How much is parking?

Self parking is free at this property.

What time is check-in at Hilton Jacksonville At Mayo Clinic?

Check-in start time: 4:00 PM; Check-in end time: 5:00 AM. Late check-in is available during limited hours.

What time is check-out at Hilton Jacksonville At Mayo Clinic?

Check-out is at 11:00 AM.

Where is Hilton Jacksonville At Mayo Clinic located?

Situated in Jacksonville, this luxury hotel is 0.3 mi (0.5 km) from Mayo Clinic Florida and within 6 mi (10 km) of Windsor Commons Shopping Center and Windsor Parke Golf Club. Adventure Landing and University of North Florida are also within 6 mi (10 km).

Have a question?

AI iconBeta

Get instant answers with AI powered search of property information and reviews.

Reviews

Hilton Jacksonville At Mayo Clinic Reviews

9.6

Exceptional

10

Cleanliness

9.8

Amenities

9.8

Staff & service

10

Eco-friendliness

10

Property conditions & facilities
Rating 10 - Excellent. 35 out of 41 reviews
Rating 8 - Good. 2 out of 41 reviews
Rating 6 - Okay. 3 out of 41 reviews
Rating 4 - Poor. 1 out of 41 reviews
Rating 2 - Terrible. 0 out of 41 reviews

Reviews

10/10 Excellent

Albert

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Great staff and rooms
Stayed 1 night in Oct 2025

10/10 Excellent

Laurie

Liked: Cleanliness, staff & service, property conditions & facilities
Very nice hotel
Stayed 4 nights in Oct 2025

10/10 Excellent

Joahnna

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Clean, comfortable, nice restaurant & coffee shop.
Stayed 3 nights in Oct 2025

10/10 Excellent

gurpreet

Liked: Cleanliness
Great location
Stayed 1 night in Oct 2025

10/10 Excellent

Shearn

Liked: Cleanliness, staff & service, property conditions & facilities
Very nice facility and staff. Would recommend to anyone visiting the Mayo Clinic.
Stayed 2 nights in Nov 2025

10/10 Excellent

Shahriar

Liked: Cleanliness, amenities, property conditions & facilities
This is by far the best Hilton in the country. Super modern, clean and classy. The room was also super nice, clean and spacious.
Stayed 1 night in Nov 2025

10/10 Excellent

STEPHEN

Liked: Cleanliness, amenities, property conditions & facilities
Very very nice
Stayed 2 nights in Oct 2025

10/10 Excellent

Laurie

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
This property is brand new and it was so nice. The staff was very helpful and very nice. We went there for Mayo Clinic. The shuttle was nice so we didn’t have to drive to the hospital and area doctor visits and tests. Wish there was a shuttle from the airport. Overall a very nice hotel.
Stayed 1 night in Oct 2025

6/10 Okay

Michael

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The room was clean, but the bed and pillows were quite worn, and the thermostat wouldn’t go above 76°F. Other than that, everything else was fine and the stay was okay overall.
Stayed 3 nights in Oct 2025

10/10 Excellent

Renee

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
I booked this hotel after seeing it on TikTok and it ended up being the perfect staycation choice. The property is new, modern, and very clean. Our room was cozy with a beautiful view of both the sunset and sunrise. The bed was incredibly comfortable, and I loved the motion-sensor lights along the sides — such a thoughtful touch for nighttime. The bathroom was spacious, and the shower was a great size. The room also had an empty mini fridge (ideal for keeping drinks chilled) and a microwave for leftovers, which made the stay even more convenient. The gym was well-equipped with quality workout machines, much better than the typical hotel gym setup. I didn’t get a chance to check out the pool this time, but I definitely plan to when I return. Overall, this Hilton exceeded my expectations. Stylish, quiet, and comfortable — I’d absolutely stay here again.
Stayed 1 night in Nov 2025

10/10 Excellent

Patty

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Beautiful hotel. Close to Mayo Clinic.
Stayed 2 nights in Nov 2025

10/10 Excellent

Kyle

Liked: Cleanliness, amenities
Everything in this brand new hotel is Beautifully designed. Elegant. Only complaint is doors slam to rooms!
Stayed 3 nights in Nov 2025

10/10 Excellent

Varun

Liked: Cleanliness, amenities
Lot of efforts taken to make guests feel special and comfortable. Special thoughts were given to address many minor details. Breakfast had lot of variety and the pool was open till 10 PM. It was perfect for staying during family vacation.
Stayed 3 nights in Nov 2025

10/10 Excellent

Pratul

Liked: Cleanliness, amenities, property conditions & facilities
Room was spotless. Friendly staff
Stayed 2 nights in Nov 2025

10/10 Excellent

Aubrey Thomas

Liked: Cleanliness, property conditions & facilities
Great experience. Beautiful lobby
Stayed 1 night in Nov 2025

10/10 Excellent

Dwayne

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Beautiful New Property!
Stayed 1 night in Nov 2025

10/10 Excellent

Aaron

Liked: Cleanliness, amenities, property conditions & facilities
Room was spotless and staff was extremely professional
Stayed 1 night in Nov 2025

10/10 Excellent

Jo

Liked: Cleanliness, amenities, property conditions & facilities
Everything was absolutely fantastic!!! Room, staff, decor, restaurant. Stayed here for an early procedure at Mayo Clinic, Jacksonville, FL.
Stayed 1 night in Nov 2025

6/10 Okay

Patrick

Liked: Cleanliness, property conditions & facilities
Nice hotel but Restaurant/Food is like gas station vending machines. Everything tastes frozen or mass produced. Yuck
Stayed 1 night in Nov 2025

10/10 Excellent

Joseph

Liked: Cleanliness, amenities, property conditions & facilities
We stayed at this newly opened hotel for three nights while I attended an appointment at the Mayo Clinic. The customer service was exceptional, and the property offers convenient amenities including an all-day restaurant, a heated pool, and shuttle service to and from the medical facilities. I highly recommend giving them a try
Stayed 2 nights in Nov 2025

10/10 Excellent

Maria

Liked: Cleanliness, staff & service, property conditions & facilities
Muy moderno y bonito el hotel
Stayed 3 nights in Oct 2025

10/10 Excellent

Theodore Thomson

Liked: Cleanliness, staff & service, property conditions & facilities
Stayed 1 night in Oct 2025

8/10 Good

Murtaza

Stayed 3 nights in Oct 2025

6/10 Okay

Gisela

Stayed 7 nights in Oct 2025
Expedia Group trademark logo

Policies

† More information about the $50 gift card with flight package benefit may be found at: https://www.expedia-aarp.com/lp/b/vacationpackages50prepaid
English Copyright 1995 - 2025. All rights reserved. Use of this Web site constitutes acceptance of the Expedia User Agreement and Privacy Policy. AARP and its affiliates do not provide retail goods or services or discounts on such goods or services. All goods or services and discounts offered via the AARP® Travel Center powered by Expedia®, are provided by third-party suppliers. AARP and its affiliates do not endorse and are not responsible for the goods or services and discounts made available on this site. Offers are subject to change and may have restrictions. Please contact the AARP Travel Center directly for full details. Expedia pays a royalty fee to AARP for the use of AARP's intellectual property. These fees are used for the general purposes of AARP.