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Holiday Inn Express & Suites St. Louis South - I-55 by IHG

Property class: 2.5

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Property amenity - Holiday Inn Express & Suites St. Louis South - I-55 by IHG (St. Louis)
Fitness facility - Holiday Inn Express & Suites St. Louis South - I-55 by IHG (St. Louis)
Property amenity - Holiday Inn Express & Suites St. Louis South - I-55 by IHG (St. Louis)
Free daily buffet breakfast - Holiday Inn Express & Suites St. Louis South - I-55 by IHG (St. Louis)
Exterior - Holiday Inn Express & Suites St. Louis South - I-55 by IHG (St. Louis)
Located in the business district, Holiday Inn Express & Suites St. Louis South - I-55 offers practical comforts for busy travelers. Enjoy a hearty breakfast buffet, reliable in-room WiFi, an indoor pool for relaxation, and a 24-hour gym.

Reviews

9.6 out of 10
Exceptional

Popular amenities

  • Free WiFi
  • Air conditioning

Room options

Available filters for rooms
Showing 10 of 10 rooms

View all photos for Standard Room, 2 Queen Beds, Accessible (Comm, Bath Shwr Combo)

Room amenity

Standard Room, 2 Queen Beds, Accessible (Comm, Bath Shwr Combo)

9.4 out of 10
Exceptional
(13 reviews)
  • 28 sq m
  • 1 bedroom
  • Sleeps 4
  • 2 Queen Beds

View all photos for Standard Room, 2 Queen Beds, Accessible (Mobil Tub)

Standard Room, 2 Queen Beds, Accessible (Mobil Tub) | In-room safe, desk, laptop workspace, blackout drapes

Standard Room, 2 Queen Beds, Accessible (Mobil Tub)

9.6 out of 10
Exceptional
(4 reviews)
  • 28 sq m
  • 1 bedroom
  • Sleeps 4
  • 2 Queen Beds

View all photos for Suite, 1 Bedroom (2 Queen, Extra Living Area)

Room amenity

Suite, 1 Bedroom (2 Queen, Extra Living Area)

9.4 out of 10
Exceptional
(30 reviews)
  • 28 sq m
  • 1 bedroom
  • Sleeps 6
  • 2 Queen Beds

View all photos for Standard Room, 1 King Bed, Accessible (Comm, Bath Shower Combo)

Room amenity

Standard Room, 1 King Bed, Accessible (Comm, Bath Shower Combo)

9.0 out of 10
Wonderful
(7 reviews)
  • 28 sq m
  • 1 bedroom
  • Sleeps 4
  • 1 King Bed

View all photos for Standard Room, 1 King Bed, Accessible (Mobil Roll In Shwr)

Free toiletries, hair dryer, towels, soap

Standard Room, 1 King Bed, Accessible (Mobil Roll In Shwr)

10.0 out of 10
Exceptional
(2 reviews)
  • 28 sq m
  • 1 bedroom
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed (Extra Living, Walk in Shwr)

Suite, 1 King Bed (Extra Living, Walk in Shwr) | In-room safe, desk, laptop workspace, blackout drapes

Suite, 1 King Bed (Extra Living, Walk in Shwr)

9.0 out of 10
Wonderful
(4 reviews)
  • 28 sq m
  • 1 bedroom
  • Sleeps 4
  • 1 King Bed

View all photos for Standard Room, 1 King Bed (Bath Shwr Combo)

Room amenity

Standard Room, 1 King Bed (Bath Shwr Combo)

9.6 out of 10
Exceptional
(17 reviews)
  • 28 sq m
  • 1 bedroom
  • Sleeps 4
  • 1 King Bed

View all photos for Standard Room

Standard Room | In-room safe, desk, laptop workspace, blackout drapes

Standard Room

  • 28 sq m
  • 1 bedroom
  • Sleeps 2
  • 1 Twin Bed

View all photos for Suite, 1 King Bed, Accessible (Mobil Tub, Extra Living)

Suite, 1 King Bed, Accessible (Mobil Tub, Extra Living) | In-room safe, desk, laptop workspace, blackout drapes

Suite, 1 King Bed, Accessible (Mobil Tub, Extra Living)

  • 28 sq m
  • 1 bedroom
  • Sleeps 4
  • 1 King Bed

View all photos for Standard Room, 2 Queen Beds

Room amenity

Standard Room, 2 Queen Beds

9.4 out of 10
Exceptional
(75 reviews)
  • 28 sq m
  • 1 bedroom
  • Sleeps 4
  • 2 Queen Beds

About the neighborhood

Located in St. Louis, Holiday Inn Express & Suites St. Louis South - I-55 by IHG is in the business district. Jefferson Barracks Historic Park and Missouri Civil War Museum are cultural highlights, and some of the area's landmarks include Ulysses S. Grant National Historic Site and Mastodon State Historic Site. Looking to enjoy an event or a game while in town? See what's happening at Webster Groves Tennis Center or Shaw Park Tennis Center. Visit our St. Louis travel guide
Map
4250 Midamerica Lane, St. Louis, MO, 63129

What's nearby

  • Busch Stadium
    Busch Stadium
    16 min drive - 17.6 miles
  • Gateway Arch
    Gateway Arch
    17 min drive - 18.0 miles
  • Union Station, St. Louis, MO
    St. Louis Union Station
    18 min drive - 17.6 miles
  • St. Louis Zoo
    St. Louis Zoo
    23 min drive - 22.2 miles
  • Barnes Jewish South Campus
    6 min walk - 0.4 miles

Getting around

  • Kirkwood Station
    17 min drive
  • St. Louis Lambert Intl. Airport (STL)
    32 min drive

Restaurants

  • McDonald's
    5 min drive
  • Burger King
    10 min walk
  • Popeyes Louisiana Kitchen
    4 min walk
  • Hardee's / Red Burrito
    11 min walk
  • Rich & Charlie's Italian Restaurant
    3 min drive

About this property

Holiday Inn Express & Suites St. Louis South - I-55 by IHG

Hotel in the business district
A free breakfast buffet, a 24-hour gym, and a business center are just a few of the amenities provided at Holiday Inn Express & Suites St. Louis South - I-55 by IHG. Stay connected with free in-room WiFi.
You'll also enjoy perks such as:
  • An indoor pool along with sun loungers
  • Free self parking
  • An elevator, meeting rooms, and a front-desk safe
  • A banquet hall, a 24-hour front desk, and a vending machine
  • Guest reviews say great things about the breakfast and helpful staff
Room features
All 99 rooms offer comforts such as laptop-friendly workspaces and air conditioning, as well as thoughtful touches like free WiFi and safes. Guest reviews highly rate the clean rooms at the property.
More amenities include:
  • Bathrooms with free toiletries and hair dryers
  • 49-inch flat-screen TVs with cable channels
  • Wardrobes/closets, refrigerators, and microwaves

Similar properties

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Hampton Inn & Suites St. Louis/South I-55
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  • Pool
  • Breakfast included
  • Pet friendly
  • Parking included
9.6 out of 10, Exceptional, 1,001 reviews
Hampton Inn & Suites St. Louis/South I-55
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Property amenities

Internet

  • Available in all rooms: Free WiFi and wired internet
  • Available in some public areas: Free WiFi

Parking and transportation

  • Free self parking on site
  • Wheelchair-accessible parking and van parking available

Food and drink

  • Free buffet breakfast available daily 6:00 AM to 9:30 AM

Things to do

  • 24-hour gym
  • Indoor pool

Family friendly

  • In-room crib
  • In-room microwave
  • In-room refrigerator
  • Indoor pool

Conveniences

  • 24-hour front desk
  • Safe at front desk
  • Vending machine

Guest services

  • Change of bedsheets (on request)
  • Change of towels on request
  • Housekeeping (daily)

Business services

  • Business center
  • Meeting rooms

Outdoors

  • Pool loungers

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Elevator
  • Stair-free path to entrance
  • Visual alarms in hallways
  • Well-lit path to entrance
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible concierge desk
  • Wheelchair-accessible gym
  • Wheelchair-accessible lounge
  • Wheelchair-accessible parking
  • Wheelchair-accessible path of travel
  • Wheelchair-accessible path to elevator
  • Wheelchair-accessible pool
  • Wheelchair-accessible public washroom
  • Wheelchair-accessible van parking

More

  • 4 floors
  • At least 10% of profits reinvested in community and sustainability
  • Banquet hall
  • No plastic drinking straws
  • Smoking not allowed

Room amenities

Bedroom

  • Bedsheets provided
  • Blackout drapes
  • Free crib

Bathroom

  • Free toiletries
  • Hair dryer
  • Private bathroom
  • Shampoo
  • Soap
  • Toilet paper
  • Toothbrush and toothpaste (on request)
  • Towels provided

Entertainment

  • 49-inch flat-screen TV with cable channels

Food and drink

  • Coffee/tea maker
  • Microwave
  • Refrigerator

More

  • Air conditioning (climate-controlled)
  • Connecting rooms available
  • Desk
  • Free local calls
  • Heating
  • Iron/ironing board
  • Laptop workspace
  • Phone
  • Safe

Policies

Check-in

Check-in start time: 3:00 PM; Check-in end time: 2:30 AM
Minimum check-in age: 21

Check-out

Check-out before 11 AM
Contactless check-out available

Special check-in instructions

Front desk staff will greet guests on arrival at the property
Information provided by the property may be translated using automated translation tools

Access methods

Staffed front desk

Pets

Pets not allowed (service animals are welcome, and are exempt from fees)

Children and extra beds

Children are welcome
Free cribs are available on request at the property

Property payment types

Important information

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
This property accepts credit cards; cash is not accepted
Safety features at this property include a fire extinguisher
This property affirms that it follows the cleaning and disinfection practices of Clean Promise (IHG)

We should mention

Pool access available from 8 AM to 10 PM
The property has connecting/adjoining rooms, which are subject to availability and can be requested by contacting the property using the number on the booking confirmation
This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly)

Property is also known as

Holiday Inn Express St. Louis South I-55 Hotel
Holiday Inn Express St. Louis South I-55
Inn Express St Louis I55
Holiday Inn Express Suites St. Louis South I 55
Holiday Inn Express Suites St. Louis South I 55 by IHG
Holiday Inn Express Suites St. Louis South I 55 an IHG Hotel
Holiday Inn Express & Suites St. Louis South - I-55 by IHG Hotel

Frequently asked questions

Does Holiday Inn Express & Suites St. Louis South - I-55 by IHG have a pool?

Yes, this property has an indoor pool. Pool access is from 8 AM–10 PM.

Is Holiday Inn Express & Suites St. Louis South - I-55 by IHG pet-friendly?

No, only service animals are welcome at the property.

How much is parking?

Self parking is free at this property.

What time is check-in at Holiday Inn Express & Suites St. Louis South - I-55 by IHG?

Check-in start time: 3:00 PM; Check-in end time: 2:30 AM.

What time is check-out at Holiday Inn Express & Suites St. Louis South - I-55 by IHG?

Check-out is at 11 AM.

Where is Holiday Inn Express & Suites St. Louis South - I-55 by IHG located?

Situated in the business district, this hotel is 0.3 mi (0.6 km) from Barnes Jewish South Campus and within 3 mi (5 km) of BounceU of St. Louis and St Anthony's. Suson Park and Kindred Hospital St. Louis South are also within 3 mi (5 km).

Can I cancel my reservation for free and receive a full refund?

Yes, this property offers free cancellation on select room rates, because flexibility matters! Please refer to the property cancellation policy on our site for more details about any exclusions or requirements.

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Reviews

Holiday Inn Express & Suites St. Louis South - I-55 by IHG Reviews

9.6

Exceptional

9.6

Cleanliness

9.4

Location

9.6

Staff & service

9.6

Property conditions & facilities
Rating 10 - Excellent. 799 out of 1000 reviews
Rating 8 - Good. 144 out of 1000 reviews
Rating 6 - Okay. 35 out of 1000 reviews
Rating 4 - Poor. 15 out of 1000 reviews
Rating 2 - Terrible. 7 out of 1000 reviews

Reviews

Verified

10/10 Excellent

Jamie

Liked: Cleanliness, staff & service
Clean room, friendly staff.
Stayed 1 night in Feb 2026
Verified

10/10 Excellent

Megan

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Great breakfast, location was ideal for activities in St Louis, complimentary parking and warm cookies at night!
Stayed 4 nights in Mar 2026
Verified

10/10 Excellent

Mary C

Liked: Cleanliness, staff & service, property conditions & facilities
Breakfast was great, quite a variety of food and drink. Staff were all kind and thoughtful. Real treat was warm cookies and milk in evening!!
Stayed 3 nights in Apr 2026
Verified

10/10 Excellent

Jennifer

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The staff was so kind and helpful. Breakfast was delicious. We really loved the fluffy scrambled eggsa and the bean to brew coffee machine. Will definitely stay again.
Stayed 2 nights in Mar 2026
Verified

10/10 Excellent

Jessica

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The breakfast was fresh, hot, and delicious. Various choices from cinnamon rolls and pancakes to cheese omelettes and sausage to cereal and yogurt. The room was clean.
Stayed 2 nights in Mar 2026
Verified

10/10 Excellent

James

Clean room, location, excellent staff
Stayed 4 nights in Dec 2025
Verified

10/10 Excellent

Anita

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Room was clean and staff was friendly.
Stayed 2 nights in Nov 2025
Verified

10/10 Excellent

Terri

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Lovely clean comfortable hotel. The only improvement would if streaming on TV was possible. But overall an excellent hotel
Stayed 1 night in Feb 2026
Verified

10/10 Excellent

James

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Clean and nice.
Stayed 2 nights in Mar 2026
Verified

10/10 Excellent

Pamela

Liked: Cleanliness, amenities, property conditions & facilities
Staff is very nice! The rooms are clean and comfortable.
Stayed 1 night in Jan 2026
Verified

10/10 Excellent

Brandy

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Friendly staff clean rooms
Stayed 1 night in Jan 2026
Verified

10/10 Excellent

Roderick

Liked: Cleanliness, amenities, property conditions & facilities
A clean room and a nice room, with a nice bathroom, comfortable bed, tv with a good selection of channels free, the warm chocolate chip cookies with milk at 8 pm was very nice complimentary, and complimentary breakfast was very good! Staff was very friendly and helpful! Nice swimming pool
Stayed 1 night in Jan 2026
Verified

8/10 Good

Eleanor

Liked: Cleanliness, staff & service, amenities
Everything was clean. Coffee was great. Breakfast was better than expected. We will be staying at this hotel our next trip to St. Louis.
Stayed 2 nights in Jan 2026
Verified

8/10 Good

Therese

Liked: Cleanliness, staff & service, amenities
Clean rooms. Easy check-in. Great breakfast.
Stayed 4 nights in Dec 2025
Verified

10/10 Excellent

Jennifer

Liked: Cleanliness, amenities, property conditions & facilities
Everything was very clean. Breakfast was good. And coffee in the lobby was really appreciated. It has been a long time since I have stayed at a Holiday Inn Express but I'd definitely stay here again.
Stayed 1 night in Jan 2026
Verified

10/10 Excellent

Kevin

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Had to make a 2 day trip to Wisconsin from Texas. As always we stayed at Holiday inn because we know we will get a nice clean place to stay with a good breakfast. Also we feel safe staying at your Hotels. Thanks to your staff, we had a worry free trip.
Stayed 2 nights in Jan 2026
Verified

10/10 Excellent

tiffany

Liked: Cleanliness, amenities, property conditions & facilities
Room was very clean! enjoyed the amenities!
Stayed 1 night in Dec 2025
Verified

10/10 Excellent

Zackariah

Liked: Cleanliness, amenities, property conditions & facilities
The breakfast was very great! They also served cookies and milk during the evening in the lobby. The gym and swimming pool were very nice and conveniently located near the elevators and outside doorway with two bathrooms nearby.
Stayed 1 night in Dec 2025
Verified

10/10 Excellent

Melissa

Liked: Cleanliness
Staff was welcoming and helpful at check in. Offered cookies and milk. The room was clean and the breakfast was good too. I would stay again.
Stayed 1 night in Dec 2025
Verified

10/10 Excellent

Tonya

Liked: Cleanliness, staff & service, amenities
Clean room, facility, exceptional continental breakfast. One issue was heat or air not working. They promptly got me a new room. Kind and courteous service. I would definitely stay here again.
Stayed 1 night in Jan 2026
Verified

10/10 Excellent

Jamie

Liked: Cleanliness, amenities, property conditions & facilities
Great staff!
Stayed 2 nights in Oct 2025
Verified

10/10 Excellent

Kalina

Staff was extremely helpful
Stayed 1 night in Nov 2025
Verified

10/10 Excellent

Jessica

Great breakfast, great rooms and comfy beds.
Stayed 1 night in May 2025
Verified

10/10 Excellent

Merry

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Exceptional front desk staff! Beautiful property! Excellent room, with spacious bathroom! Everything was perfect!
Stayed 1 night in Nov 2025
Verified

10/10 Excellent

James

Very nice new hotel and even the breakfast was great.
Stayed 2 nights in Jul 2025