
Business Hotels in St. Charles 2025
Featured St. Charles Business Hotels

Home2 Suites by Hilton St. Charles St.Louis
32 Research Park Circle St. Charles MO

Best Western Plus The Charles Hotel
1425 South 5th Street St. Charles MO
Fully refundableReserve now, pay when you stay

Embassy Suites by Hilton St. Louis St. Charles
2 Convention Center Plz St. Charles MO
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Country Inn & Suites by Radisson, St. Charles Historic District
1190 S Main St St. Charles MO

Ameristar Casino Resort and Spa
1 Ameristar Blvd St. Charles MO
Fully refundableReserve now, pay when you stay

Hampton Inn St. Charles St. Peters
3720 W Clay St St. Charles MO
Fully refundableReserve now, pay when you stay
Red Roof Inn St Louis - St Charles
2010 Zumbehl Road St. Charles MO

Americas Best Value Inn & Suites St. Louis, St. Charles Inn
1310 Bass Pro Drive St. Charles MO
Fully refundableReserve now, pay when you stay

Comfort Suites St Charles - St Louis
1400 S 5th St St. Charles MO

Holiday Inn Express Hotel and Suites St. Charles by IHG
3098 Elm Point Industrial Drive St. Charles MO
Fully refundable

Drury Plaza Hotel St. Louis St. Charles
380 Mulholland Drive St. Charles MO

Sleep Inn & Suites
150 Fountain Lakes Blvd St. Charles MO

Candlewood Suites St Louis St Charles by IHG
1800 Zumbehl Rd St. Charles MO
Fully refundable

WoodSpring Suites St Louis St Charles
2100 Old Hwy 94 S St. Charles MO

Super 8 by Wyndham St Charles
3040 W Clay St St. Charles MO

Baymont by Wyndham St. Charles
801 Veterans Memorial Parkway St. Charles MO

Relax Inn Saint Charles
3800 Harry S Truman Blvd St. Charles MO
Fully refundable
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.