We had a suite on the third floor of a historical building in the middle of Old Town right between Charles Bridge and Old Town Square. Very walkable to everywhere, lots of shops and restaurants within easy reach. The suite was spacious with historical painted wood ceilings but a modern bed and bathroom. There was also a queen bed in the main living area. The only small thing missing was conditioner in the shower, otherwise we had all we needed. The building is accessible to a point: there is an elevator, but there is a step up from the street, a heavy narrow doorway and narrow passages. Also note that there is no reception/staff on site. This was not an issue for us in any way, but just be aware that registration is done over email and there is a number to call if you need help.