San Francisco Vacation Packages for 2026

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San Francisco Flight + Hotel packages

Price found within the past 48 hours. Click for updated prices.
Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino

$768
per person
Oct 24 - Oct 28
found 1 day ago
Roundtrip non-stop flight included
Orlando (MCO) to Panama City (PTY)
Book a stay at this family-friendly resort in Tocumen. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in our reviews. Popular attractions Metromall Panama and Los Pueblos Commercial Center are located nearby.
Not all the rooms come with a fridge.

Reviewed on Aug 21, 2026

Megapolis Hotel Panamá

Megapolis Hotel Panamá

San Francisco
Save 100% on your flight
$902
per person
Oct 24 - Oct 28
found 1 day ago
Roundtrip non-stop flight included
Orlando (MCO) to Panama City (PTY)
Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Albrook Shopping Mall and Avenida Balboa are located nearby.
everything very nice

Reviewed on Aug 22, 2026

Hyatt Regency Panama City

Hyatt Regency Panama City

Bella Vista
$807
per person
Oct 24 - Oct 28
found 1 day ago
Roundtrip non-stop flight included
Orlando (MCO) to Panama City (PTY)
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, free valet parking, and 2 restaurants. Popular attractions Albrook Shopping Mall and Via Espana are located nearby.
Everything was excellent No complaints about anything

Reviewed on Aug 21, 2026

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

Bella Vista
$866
per person
Oct 25 - Oct 29
found 1 day ago
Roundtrip non-stop flight included
Orlando (MCO) to Panama City (PTY)
Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and 3 restaurants. Our guests praise the breakfast and the pool in our reviews. Popular attractions Albrook Shopping Mall and Avenida Balboa are located nearby.
La Concordia Boutique Hotel

La Concordia Boutique Hotel

Casco Viejo
$1,517
per person
Oct 25 - Oct 29
found 1 day ago
Roundtrip non-stop flight included
Orlando (MCO) to Panama City (PTY)
Book a stay at this family-friendly hotel in Panama City. Enjoy free WiFi, onsite spa services, and an airport shuttle (surcharge). Our guests praise the helpful staff and the property condition in our reviews. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.
Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

San Francisco
$770
per person
Oct 24 - Oct 28
found 1 day ago
Roundtrip non-stop flight included
Orlando (MCO) to Panama City (PTY)
Book a stay at this spa hotel in Panama City. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Albrook Shopping Mall and Avenida Balboa are located nearby.
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Top Hotel Deals

Megapolis Hotel Panamá

Megapolis Hotel Panamá

Avenida Balboa Panama City
2.07 km from San Francisco
Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
Aloft by Marriott Panama

Aloft by Marriott Panama

Via Israel & Calle 76 Panama City Panama
0.61 km from San Francisco
Book a stay at this business-friendly hotel in Panama City. Enjoy free WiFi, free parking, and a nightclub. Our guests praise the helpful staff in our reviews. ...
Courtyard by Marriott Panama Multiplaza Mall

Courtyard by Marriott Panama Multiplaza Mall

Via Israel Multiplaza Pacific Mall Panama City Panama
1.05 km from San Francisco
Book a stay at this business-friendly hotel in Panama City. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff in ...
Decapolis Hotel Panama City

Decapolis Hotel Panama City

Avenida Balboa Con Multicentro Panama City Panama
2.01 km from San Francisco
Book a stay at this spa hotel in Panama City. Enjoy free breakfast, free WiFi, and free valet parking. Our guests praise the breakfast and the helpful staff ...
Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

Av. Balboa con Calle 53 Panama City Panama
1.92 km from San Francisco
Book a stay at this spa hotel in Panama City. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the breakfast and the helpful staff in ...
Ramada Plaza by Wyndham Panama Punta Pacifica

Ramada Plaza by Wyndham Panama Punta Pacifica

Via Israel y Calle 71, San Francisco Panama City Panama
0.58 km from San Francisco
Book a stay at this business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and room service. Our guests praise the breakfast and the helpful ...
Plaza Paitilla Inn Hotel

Plaza Paitilla Inn Hotel

Italy Avenue, Punta Paitilla Panama City Panama
2.31 km from San Francisco
Book a stay at this business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in ...
JW Marriott Panama

JW Marriott Panama

Calle Punta Colon, Punta Pacifica Panama City Panama
1.93 km from San Francisco
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, 4 outdoor pools, and 3 restaurants. Our guests praise the helpful staff in our reviews. Popular ...
Sheraton Grand Panama

Sheraton Grand Panama

Via Israel And 77th Street Panama City Panama
0.75 km from San Francisco
Book a stay at this spa resort in Panama City. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff and the property condition ...
Residence Inn by Marriott Panama City

Residence Inn by Marriott Panama City

CALLE RAMON H JURADO EDIFICO P Panama City
1.71 km from San Francisco
Book a stay at this business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
Dovle Residences by HMS-Preferred Member

Dovle Residences by HMS-Preferred Member

Vía Cincuentenario Panama City Provincia de Panamá
1.57 km from San Francisco
Book a stay at this business-friendly apartment in Panama City. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Albrook Shopping Mall ...
Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

Calle 50, Urb. Marbella Panama City Panama
1.99 km from San Francisco
Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and 3 restaurants. Our guests praise the breakfast and the pool in our reviews. ...
Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

Ave. Domingo Diaz Tocumen Panama
15.65 km from San Francisco
Book a stay at this family-friendly hotel in Tocumen. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the breakfast and ...
Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

Plaza de la Independencia Casco Viejo Panama City Panama
5.39 km from San Francisco
Book a stay at this spa hotel in Panama City. Enjoy free WiFi, a full-service spa, and 3 restaurants. Our guests praise the helpful staff and the clean rooms ...
Dreams Playa Bonita Panama - All Inclusive

Dreams Playa Bonita Panama - All Inclusive

KM 7, Road to Veracruz Veracruz Panama
13.34 km from San Francisco
Book a stay at this beach property in Veracruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the pool and the helpful staff in our reviews. ...
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Flight Deals

These prices were available within the past 7 days. Prices quoted are per person, round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Copa
avianca
United
Tue, Oct 20 - Mon, Oct 26
FLL
Fort Lauderdale - Hollywood Intl.
PTY
Tocumen Intl.
$517
Roundtrip
found 1 day ago
Select United flight, departing Tue, Oct 20 from Fort Lauderdale - Hollywood Intl. to Tocumen Intl., returning Mon, Oct 26, priced at $517 found 1 day ago
Delta
Fri, Oct 16 - Fri, Nov 6
ATL
Hartsfield-Jackson Atlanta Intl.
PTY
Tocumen Intl.
$616
Roundtrip
found 2 days ago
Select Delta flight, departing Fri, Oct 16 from Hartsfield-Jackson Atlanta Intl. to Tocumen Intl., returning Fri, Nov 6, priced at $616 found 2 days ago