Mission District Vacation Packages for 2025

Build a Flight + Hotel Bundle & Save up to $536 On Your Vacation*

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Mission District Flight + Hotel packages

Price found within the past 48 hours. Click for updated prices.
Fitzgerald Hotel

Fitzgerald Hotel

3 out of 5
Union Square
Save 100% on your flight
Price was $550, price is now $280 per person
$280
per person
Oct 28 - Nov 1
found 1 day ago
Roundtrip flight included
Denver (DEN) to San Francisco (SFO)
Stay at this hotel in San Francisco. Enjoy free breakfast, free WiFi, and valet parking (surcharge). Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Oracle Park and Pier 39 are located nearby.

Bay Landing San Francisco Airport Hotel

Bay Landing San Francisco Airport Hotel

3 out of 5
Save 100% on your flight
Price was $597, price is now $359 per person
$359
per person
Oct 28 - Nov 1
found 1 day ago
Roundtrip flight included
Denver (DEN) to San Francisco (SFO)
Stay at this 3-star business-friendly hotel in Burlingame. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Bayfront Park and Millbrae Square Shopping Center are located nearby.

Nob Hill Hotel

Nob Hill Hotel

4 out of 5
Downtown San Francisco
Save 100% on your flight
Price was $721, price is now $442 per person
$442
per person
Oct 28 - Nov 1
found 1 day ago
Roundtrip flight included
Denver (DEN) to San Francisco (SFO)
Stay at this 4-star hotel in San Francisco. Enjoy free breakfast, free WiFi, and room service. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Pier 39 and Oracle Park are located nearby.

Argonaut Hotel

Argonaut Hotel

4.5 out of 5
Fisherman's Wharf
Save 100% on your flight
Price was $1,153, price is now $709 per person
$709
per person
Oct 29 - Nov 3
found 1 day ago
Roundtrip flight included
Phoenix (PHX) to San Francisco (SFO)
Stay at this 4.5-star luxury hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the restaurant and the helpful staff in our reviews. Popular attractions Pier 39 and Alcatraz Island are located nearby.

Hotel Riu Plaza Fisherman's Wharf

Hotel Riu Plaza Fisherman's Wharf

4 out of 5
Fisherman's Wharf
Save 100% on your flight
Price was $870, price is now $538 per person
$538
per person
Oct 28 - Nov 1
found 1 day ago
Roundtrip flight included
Denver (DEN) to San Francisco (SFO)
Book a stay at this eco-certified hotel in San Francisco. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the pool in our reviews. Popular attractions Pier 39 and Alcatraz Island are located nearby.

The Andrews Hotel

The Andrews Hotel

4 out of 5
Union Square
Save 100% on your flight
Price was $714, price is now $447 per person
$447
per person
Oct 28 - Nov 1
found 1 day ago
Roundtrip flight included
Denver (DEN) to San Francisco (SFO)
Stay at this 4-star business-friendly hotel in San Francisco. Enjoy free breakfast, free WiFi, and room service. Our guests praise the restaurant and the helpful staff in our reviews. Popular attractions Oracle Park and Pier 39 are located nearby.

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Top Hotel Deals

Holiday Inn Golden Gateway by IHG

Holiday Inn Golden Gateway by IHG

3.5 out of 5
1500 Van Ness Ave, San Francisco, CA
3.43 km from Mission District
Book a stay at this business-friendly hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the pool ...
Hyatt Regency San Francisco

Hyatt Regency San Francisco

4 out of 5
5 Embarcadero Center, San Francisco, CA
4.22 km from Mission District
Stay at this 4-star eco-certified hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the ...
Hotel Riu Plaza Fisherman's Wharf

Hotel Riu Plaza Fisherman's Wharf

4 out of 5
2500 Mason St, San Francisco, CA
5.3 km from Mission District
Book a stay at this eco-certified hotel in San Francisco. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and ...
Crowne Plaza San Francisco Airport by IHG

Crowne Plaza San Francisco Airport by IHG

3.5 out of 5
1177 Airport Blvd, Burlingame, CA
19.41 km from Mission District
Stay at this 3.5-star business-friendly hotel in Burlingame. Enjoy free WiFi, room service, and a fitness center. Our guests praise the helpful staff and the ...
Club Quarters Hotel in San Francisco

Club Quarters Hotel in San Francisco

4 out of 5
424 Clay St, San Francisco, CA
4.2 km from Mission District
Stay at this 4-star business-friendly hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and ...
Best Western Plus Grosvenor Airport Hotel

Best Western Plus Grosvenor Airport Hotel

3 out of 5
380 S Airport Boulevard, South San Francisco, CA
12.92 km from Mission District
Stay at this 3-star business-friendly hotel in South San Francisco. Enjoy free breakfast, a free airport shuttle, and room service. Our guests praise the helpful ...
Hilton San Francisco Financial District

Hilton San Francisco Financial District

4 out of 5
750 Kearny St, San Francisco, CA
4.11 km from Mission District
Book a stay at this business-friendly hotel in San Francisco. Enjoy breakfast (surcharge), a fitness center, and WiFi (surcharge). Our guests praise the helpful ...
Fairmont San Francisco

Fairmont San Francisco

5 out of 5
950 Mason Street Atop Nob Hill, San Francisco, CA
3.72 km from Mission District
Stay at this 5-star luxury hotel in San Francisco. Enjoy a full-service spa, 2 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the property ...
Chancellor Hotel on Union Square

Chancellor Hotel on Union Square

3.5 out of 5
433 Powell St, San Francisco, CA
3.35 km from Mission District
Stay at this 3.5-star hotel in San Francisco. Enjoy free WiFi, a 24-hour front desk, and daily housekeeping. Our guests praise the helpful staff and the clean ...
Handlery Union Square Hotel

Handlery Union Square Hotel

3.5 out of 5
351 Geary St, San Francisco, CA
3.17 km from Mission District
Book a stay at this business-friendly hotel in San Francisco. Enjoy free WiFi, a fitness center, and valet parking (surcharge). Our guests praise the pool and ...
DoubleTree by Hilton Hotel Berkeley Marina

DoubleTree by Hilton Hotel Berkeley Marina

4 out of 5
200 Marina Blvd, Berkeley, CA
15.18 km from Mission District
Stay at this 4-star eco-certified hotel in Berkeley. Enjoy free WiFi, a marina, and breakfast (surcharge). Our guests praise the breakfast and the restaurant ...
FOUND Hotel Carlton, Nob Hill

FOUND Hotel Carlton, Nob Hill

2 out of 5
1075 Sutter St, San Francisco, CA
3.18 km from Mission District
Stay at this hotel in San Francisco. Enjoy free WiFi, a 24-hour front desk, and Netflix. Our guests praise the helpful staff in our reviews. Popular attractions ...
Bay Landing San Francisco Airport Hotel

Bay Landing San Francisco Airport Hotel

3 out of 5
1550 Bayshore Hwy, Burlingame, CA
18.41 km from Mission District
Stay at this 3-star business-friendly hotel in Burlingame. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
Hotel Caza Fisherman's Wharf

Hotel Caza Fisherman's Wharf

4 out of 5
1300 Columbus Avenue, San Francisco, CA
5.26 km from Mission District
Stay at this 4-star family-friendly hotel in San Francisco. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the pool ...
Mayflower Hotel

Mayflower Hotel

2 out of 5
975 Bush St, San Francisco, CA
3.36 km from Mission District
Stay at this hotel in San Francisco. Enjoy free breakfast, free WiFi, and a 24-hour front desk. Popular attractions Pier 39 and Oracle Park are located ...
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See all available properties in Mission District
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Flight Deals

These prices were available within the past 7 days. Prices quoted are per person, round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Frontier Airlines
Wed, Nov 19 - Wed, Dec 3
LAX
Los Angeles Intl.
SFO
San Francisco Intl.
$74 Roundtrip, found 4 days ago
$74
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Wed, Nov 19 from Los Angeles Intl. to San Francisco Intl., returning Wed, Dec 3, priced at $74 found 4 days ago
Alaska Airlines
Wed, Nov 19 - Wed, Dec 3
LAX
Los Angeles Intl.
SFO
San Francisco Intl.
$87 Roundtrip, found 4 days ago
$87
Roundtrip
found 4 days ago
Select Alaska Airlines flight, departing Wed, Nov 19 from Los Angeles Intl. to San Francisco Intl., returning Wed, Dec 3, priced at $87 found 4 days ago
American Airlines
Wed, Nov 19 - Wed, Dec 3
LAX
Los Angeles Intl.
SFO
San Francisco Intl.
$97 Roundtrip, found 4 days ago
$97
Roundtrip
found 4 days ago
Select American Airlines flight, departing Wed, Nov 19 from Los Angeles Intl. to San Francisco Intl., returning Wed, Dec 3, priced at $97 found 4 days ago
Delta
Wed, Nov 19 - Wed, Dec 3
LAX
Los Angeles Intl.
SFO
San Francisco Intl.
$97 Roundtrip, found 4 days ago
$97
Roundtrip
found 4 days ago
Select Delta flight, departing Wed, Nov 19 from Los Angeles Intl. to San Francisco Intl., returning Wed, Dec 3, priced at $97 found 4 days ago
United
Wed, Nov 19 - Wed, Dec 3
LAX
Los Angeles Intl.
SFO
San Francisco Intl.
$97 Roundtrip, found 4 days ago
$97
Roundtrip
found 4 days ago
Select United flight, departing Wed, Nov 19 from Los Angeles Intl. to San Francisco Intl., returning Wed, Dec 3, priced at $97 found 4 days ago