Mission Bay Vacation Packages for 2026

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Mission Bay Flight + Hotel packages

Price found within the past 48 hours. Click for updated prices.
Hilton San Diego Gaslamp Quarter

Hilton San Diego Gaslamp Quarter

4 out of 5
Downtown San Diego
Save 100% on your flight
Price was $744, price is now $473 per person
$473
per person
Apr 3 - Apr 7
found 1 day ago
Roundtrip flight included
Chicago (ORD) to San Diego (SAN)
Book a stay at this business-friendly hotel in San Diego. Enjoy breakfast (surcharge), a 24-hour fitness center, and WiFi (surcharge). Our guests praise the helpful staff in our reviews. Popular attractions Petco Park and Port of San Diego are located nearby.

The Sofia Hotel

The Sofia Hotel

3.5 out of 5
Downtown San Diego
Save 100% on your flight
Price was $1,505, price is now $800 per person
$800
per person
Mar 22 - Mar 27
found 13 hours ago
Roundtrip non-stop flight included
Milwaukee (MKE) to San Diego (SAN)
Book a stay at this historic hotel in San Diego. Enjoy free WiFi, room service, and a 24-hour fitness center. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Port of San Diego and Petco Park are located nearby.

Paradise Point Resort & Spa

Paradise Point Resort & Spa

4 out of 5
Mission Bay
Save 100% on your flight
Price was $1,143, price is now $680 per person
$680
per person
Mar 22 - Mar 27
found 13 hours ago
Roundtrip non-stop flight included
Milwaukee (MKE) to San Diego (SAN)
Book a stay at this beach resort in San Diego. Enjoy free WiFi, 5 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in our reviews. Popular attractions Mission Bay and Port of San Diego are located nearby.

Margaritaville Hotel San Diego Gaslamp Quarter

Margaritaville Hotel San Diego Gaslamp Quarter

4 out of 5
Downtown San Diego
Save 100% on your flight
Price was $1,697, price is now $1,068 per person
$1,068
per person
Mar 22 - Mar 27
found 13 hours ago
Roundtrip non-stop flight included
Milwaukee (MKE) to San Diego (SAN)
Stay at this hotel in San Diego. Enjoy a rooftop terrace, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Petco Park and Port of San Diego are located nearby.

Alma San Diego Downtown, a Tribute Portfolio Hotel

Alma San Diego Downtown, a Tribute Portfolio Hotel

4 out of 5
Downtown San Diego
Save 100% on your flight
Price was $779, price is now $501 per person
$501
per person
Apr 3 - Apr 7
found 1 day ago
Roundtrip flight included
Chicago (ORD) to San Diego (SAN)
Book a stay at this boutique hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the helpful staff in our reviews. Popular attractions Petco Park and Port of San Diego are located nearby.

The Beau Downtown San Diego Gaslamp Quar

The Beau Downtown San Diego Gaslamp Quar

3 out of 5
Downtown San Diego
Save 100% on your flight
Price was $1,286, price is now $865 per person
$865
per person
Mar 22 - Mar 27
found 13 hours ago
Roundtrip non-stop flight included
Milwaukee (MKE) to San Diego (SAN)
Stay at this hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and parking (surcharge). Popular attractions Petco Park and Port of San Diego are located nearby.

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Top Hotel Deals

Paradise Point Resort & Spa

Paradise Point Resort & Spa

4 out of 5
1404 Vacation Rd San Diego CA
1.55 km from Mission Bay
Book a stay at this beach resort in San Diego. Enjoy free WiFi, 5 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...
The Dana on Mission Bay

The Dana on Mission Bay

3.5 out of 5
1710 W Mission Bay Dr San Diego CA
1.75 km from Mission Bay
Stay at this hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 hot tubs. Our guests praise the pool and the restaurant in our reviews. Popular attractions ...
San Diego Mission Bay Resort

San Diego Mission Bay Resort

4 out of 5
1775 E Mission Bay Dr San Diego CA
1.16 km from Mission Bay
Book a stay at this beach hotel in San Diego. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the pool and the helpful staff in our ...
Hyatt Regency Mission Bay Spa and Marina

Hyatt Regency Mission Bay Spa and Marina

4 out of 5
1441 Quivira Rd San Diego CA
2.01 km from Mission Bay
Book a stay at this spa hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in our ...
Bay Club Hotel & Marina

Bay Club Hotel & Marina

3.5 out of 5
2131 Shelter Island Dr San Diego CA
6.77 km from Mission Bay
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, a marina, and a health club. Our guests praise the breakfast and the restaurant in ...
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl San Diego CA
8.97 km from Mission Bay
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 6 restaurants, and 3 bars/lounges. Our guests praise the pool and the helpful staff ...
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4 out of 5
207 5th Ave San Diego CA
9.66 km from Mission Bay
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the helpful staff and the convenient parking in our reviews. ...
The Sofia Hotel

The Sofia Hotel

3.5 out of 5
150 W Broadway San Diego CA
8.69 km from Mission Bay
Book a stay at this historic hotel in San Diego. Enjoy free WiFi, room service, and a 24-hour fitness center. Our guests praise the helpful staff and the clean ...
The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

3 out of 5
1617 1st Avenue San Diego CA
8.2 km from Mission Bay
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr San Diego CA
5.95 km from Mission Bay
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and 5 restaurants. Our guests praise the pool and the restaurant ...
Hilton San Diego Mission Valley

Hilton San Diego Mission Valley

4 out of 5
901 Camino Del Rio S San Diego CA
6.38 km from Mission Bay
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the ...
DoubleTree by Hilton San Diego - Del Mar

DoubleTree by Hilton San Diego - Del Mar

4 out of 5
11915 El Camino Real San Diego CA
17.76 km from Mission Bay
Book a stay at this business-friendly hotel in San Diego. Enjoy breakfast (surcharge), room service, and a fitness center. Our guests praise the helpful staff ...
Courtyard by Marriott San Diego Downtown Little Italy

Courtyard by Marriott San Diego Downtown Little Italy

4 out of 5
1646 Front St San Diego CA
8.08 km from Mission Bay
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
7.95 km from Mission Bay
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
Sentral Gaslamp Quarter

Sentral Gaslamp Quarter

4 out of 5
502 10th Avenue San Diego CA
9.64 km from Mission Bay
Stay at this hotel in San Diego. Enjoy free WiFi, a rooftop terrace, and a 24-hour fitness center. Popular attractions Petco Park and Port of San Diego are located ...
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See all available properties in Mission Bay
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Flight Deals

These prices were available within the past 7 days. Prices quoted are per person, round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Frontier Airlines
Sun, Mar 22 - Mon, Mar 30
DEN
Denver Intl.
SAN
San Diego Intl.
$66 Roundtrip, found 2 days ago
$66
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Sun, Mar 22 from Denver Intl. to San Diego Intl., returning Mon, Mar 30, priced at $66 found 2 days ago
Alaska Airlines
Tue, Feb 24 - Sat, Feb 28
ORD
O'Hare Intl.
SAN
San Diego Intl.
$157 Roundtrip, found 12 hours ago
$157
Roundtrip
found 12 hours ago
Select Alaska Airlines flight, departing Tue, Feb 24 from O'Hare Intl. to San Diego Intl., returning Sat, Feb 28, priced at $157 found 12 hours ago
American Airlines
Tue, Feb 17 - Fri, Feb 20
DEN
Denver Intl.
CLD
McClellan-Palomar
$159 Roundtrip, found 3 days ago
$159
Roundtrip
found 3 days ago
Select American Airlines flight, departing Tue, Feb 17 from Denver Intl. to McClellan-Palomar, returning Fri, Feb 20, priced at $159 found 3 days ago
Hawaiian Airlines
Mon, Feb 23 - Tue, Mar 3
BOS
Logan Intl.
SAN
San Diego Intl.
$227 Roundtrip, found 1 day ago
$227
Roundtrip
found 1 day ago
Select Hawaiian Airlines flight, departing Mon, Feb 23 from Logan Intl. to San Diego Intl., returning Tue, Mar 3, priced at $227 found 1 day ago
Delta
Fri, Aug 21 - Sat, Sep 5
EWR
Newark Liberty Intl. Airport
SAN
San Diego Intl.
$237 Roundtrip, found 6 days ago
$237
Roundtrip
found 6 days ago
Select Delta flight, departing Fri, Aug 21 from Newark Liberty Intl. Airport to San Diego Intl., returning Sat, Sep 5, priced at $237 found 6 days ago