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Hilton Jacksonville At Mayo Clinic

4.5 star property

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Breakfast, lunch, dinner served; American cuisine - Hilton Jacksonville At Mayo Clinic (Jacksonville)
Lobby - Hilton Jacksonville At Mayo Clinic (Jacksonville)
Lobby - Hilton Jacksonville At Mayo Clinic (Jacksonville)
Lake view - Hilton Jacksonville At Mayo Clinic (Jacksonville)
Terrace/patio - Hilton Jacksonville At Mayo Clinic (Jacksonville)
A short walk from Mayo Clinic Florida, Hilton Jacksonville At Mayo Clinic provides a grocery/convenience store, a firepit, and dry cleaning/laundry services. The on-site American cuisine restaurant, Coastal Kitchen, offers breakfast, lunch, dinner, and kids' meals. Stay connected with free in-room WiFi, with speed of 25+ Mbps, and guests can find other amenities such as a bar and a gym.

Reviews

9.4 out of 10
Exceptional

Popular amenities

  • Pool
  • Free WiFi
  • Restaurant
  • Air conditioning
  • Gym

Room options

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Showing 19 of 19 rooms

View all photos for Room, 1 King Bed

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 1 King Bed

8.8 out of 10
Excellent
(6 reviews)
  • Sleeps 2
  • 1 King Bed

View all photos for Deluxe Room, 1 King Bed (Water View)

View from room

Deluxe Room, 1 King Bed (Water View)

  • Water view
  • Sleeps 2
  • 1 King Bed

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View from room

Deluxe Room, 1 King Bed, Accessible (Roll-In Shower)

  • Sleeps 2
  • 1 King Bed

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Premium bedding, in-room safe, blackout drapes, iron/ironing board

Junior Suite, 1 King Bed

  • Sleeps 4
  • 1 King Bed

View all photos for Junior Suite, 1 King Bed, Corner

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Junior Suite, 1 King Bed, Corner

  • Sleeps 4
  • 1 King Bed

View all photos for Junior Suite, 1 King Bed, Accessible (Roll-In Shower)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Junior Suite, 1 King Bed, Accessible (Roll-In Shower)

  • Sleeps 2
  • 1 King Bed

View all photos for Junior Suite, 1 King Bed, Accessible (Roll-In Shower)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Junior Suite, 1 King Bed, Accessible (Roll-In Shower)

  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed, Accessible (Mobility & Hearing, Roll-In Shower)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Suite, 1 King Bed, Accessible (Mobility & Hearing, Roll-In Shower)

  • Sleeps 2
  • 1 King Bed

View all photos for Room, 1 King Bed (Water View)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 1 King Bed (Water View)

9.0 out of 10
Wonderful
(2 reviews)
  • Water view
  • Sleeps 2
  • 1 King Bed

View all photos for Room, 1 King Bed (Water View, Roll-In Shower)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 1 King Bed (Water View, Roll-In Shower)

  • Water view
  • Sleeps 2
  • 1 King Bed

View all photos for Room, 1 King Bed, Accessible (Hearing)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 1 King Bed, Accessible (Hearing)

  • Sleeps 2
  • 1 King Bed

View all photos for Room, 1 King Bed, Accessible (Roll-In Shower)

Room, 1 King Bed, Accessible (Roll-In Shower) | Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 1 King Bed, Accessible (Roll-In Shower)

  • Sleeps 2
  • 1 King Bed

View all photos for Room, 1 King Bed, Accessible (Hearing)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 1 King Bed, Accessible (Hearing)

  • Sleeps 2
  • 1 King Bed

View all photos for Room, 2 Queen Beds

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 2 Queen Beds

9.6 out of 10
Exceptional
(22 reviews)
  • Sleeps 4
  • 2 Queen Beds

View all photos for Room, 2 Queen Beds, Accessible (Water View, Hearing)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 2 Queen Beds, Accessible (Water View, Hearing)

  • Water view
  • Sleeps 4
  • 2 Queen Beds

View all photos for Room, 2 Queen Beds, Accessible, Bathtub

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 2 Queen Beds, Accessible, Bathtub

10.0 out of 10
Exceptional
(1 review)
  • Sleeps 4
  • 2 Queen Beds

View all photos for Room, 2 Queen Beds, Accessible (Hearing)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 2 Queen Beds, Accessible (Hearing)

9.0 out of 10
Wonderful
(2 reviews)
  • Sleeps 4
  • 2 Queen Beds

View all photos for Room, 2 Queen Beds (Water View)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 2 Queen Beds (Water View)

10.0 out of 10
Exceptional
(1 review)
  • Water view
  • Sleeps 4
  • 2 Queen Beds

View all photos for Room, 2 Queen Beds, Accessible, Bathtub (View)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 2 Queen Beds, Accessible, Bathtub (View)

  • Sleeps 4
  • 2 Queen Beds

About the neighborhood

Jacksonville is home to Hilton Jacksonville At Mayo Clinic. Players by the Sea and Beaches Museum & History Park are cultural highlights, and some of the area's landmarks include San Jose Episcopal Church and Fort Caroline National Memorial. Looking to enjoy an event or a game while in town? See what's happening at EverBank Stadium or Jacksonville Beach Tennis Center. Visit our Jacksonville travel guide
Map
4745 Transformation Way, Jacksonville, FL, 32224

What's nearby

  • Jacksonville_UniversityofNorthFlorida_6127797_04
    University of North Florida
    6 min drive - 5.2 miles
  • Jacksonville_StJohnsTownCenter_6127793_05
    St. Johns Town Center
    8 min drive - 7.2 miles
  • Golf Course
    TPC Sawgrass
    13 min drive - 9.1 miles
  • Mayport Naval Station
    Mayport Naval Station
    17 min drive - 11.6 miles
  • F/A-18 Hornets at NAS Jacksonville
    Jacksonville Naval Air Station
    32 min drive - 29.2 miles

Getting around

  • Jacksonville Station
    28 min drive
  • Jacksonville International Airport (JAX)
    33 min drive

Restaurants

  • Culver’s
    3 min drive
  • Starbucks
    3 min drive
  • Circle K
    16 min walk
  • Starbucks
    13 min walk
  • M Brothers at Mayo
    14 min walk

About this property

Hilton Jacksonville At Mayo Clinic

Luxury hotel near St. Johns Town Center
A short walk from Mayo Clinic Florida, Hilton Jacksonville At Mayo Clinic provides a grocery/convenience store, a firepit, and dry cleaning/laundry services. The on-site American cuisine restaurant, Coastal Kitchen, offers breakfast, lunch, dinner, and kids' meals. In addition to a bar and a gym, guests can connect to free in-room WiFi, with speed of 25+ Mbps.
Other perks at this hotel include:
  • An outdoor pool along with sun loungers and pool umbrellas
  • Buffet breakfast (surcharge), a free area shuttle, and self parking (surcharge)
  • An electric car charging station, express check-out, and smoke-free premises
  • Concierge services, 12 meeting rooms, and a 24-hour front desk
Room features
All 252 rooms offer comforts such as premium bedding and laptop-compatible safes, as well as perks like late night room service and free WiFi.
Extra conveniences in all rooms include:
  • Recycling and LED light bulbs
  • Tubs or showers, hair dryers, and shampoo
  • 55-inch Smart TVs with Netflix, streaming services, and premium channels
  • Mini fridges, free infant beds, and coffee/tea makers

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Property amenities

Internet

  • Available in all rooms: Free WiFi
  • In-room WiFi speed: 25+ Mbps
  • Available in some public areas: Free WiFi

Parking and transportation

  • Electric car charging station on site
  • Free area shuttle up to 350 yds
  • Uncovered self parking on site (USD 12 per night)

Food and drink

  • Daily buffet breakfast available 6:00 AM to 10:30 AM for a fee: USD 26.99 to 26.99 for adults and USD 15 to 30 for children
  • A bar/lounge
  • A restaurant

Restaurants on site

  • Coastal Kitchen
  • Coastal Kitchen Bar

Things to do

  • Gym
  • Outdoor pool
  • TV in common areas

Family friendly

  • Free area shuttle
  • Grocery/convenience store
  • In-room crib
  • Laundry facilities
  • Mini-fridge
  • Outdoor pool
  • Rollaway/extra bed (surcharge)

Conveniences

  • 24-hour front desk
  • Grocery/convenience store
  • Laundry facilities
  • Luggage storage

Guest services

  • Concierge services
  • Dry cleaning/laundry service
  • Housekeeping (daily)
  • Porter/bellhop
  • Proposal/romance packages
  • Wedding services

Business services

  • 12 meeting rooms
  • 20,000 square feet of conference space
  • Coworking space

Outdoors

  • Firepit
  • Outdoor furniture
  • Pool loungers
  • Pool umbrellas

Accessibility

  • Tile flooring in public areas

More

  • 1 building
  • 8 floors
  • At least 80% lighting from LEDs
  • At least 80% of food locally-sourced
  • Built in 2025
  • Comprehensive food waste policy
  • Smoking not allowed
  • Traditional architecture
  • Vegetarian breakfast available
  • Vegetarian dining options

Room amenities

Bedroom

  • Blackout drapes
  • Free crib
  • Premium bedding
  • Rollaway/extra bed (surcharge)

Bathroom

  • Bathtub or shower
  • Hair dryer
  • Shampoo
  • Soap
  • Toilet paper
  • Towels provided

Entertainment

  • 55-inch smart TV with premium cable channels
  • Netflix
  • Streaming services

Food and drink

  • Coffee/tea maker
  • Free bottled water
  • Late-night room service
  • Mini-fridge

More

  • Air conditioning
  • Free local calls
  • Free long-distance calls
  • Heating
  • Iron/ironing board
  • Laptop-compatible safe
  • LED lighting
  • Mobile key entry
  • Phone
  • Recycling
  • Water-efficient showers
  • Water-efficient toilets

Policies

Check-in

Check-in start time: 4:00 PM; Check-in end time: 5:00 AM
Late check-in subject to availability
Minimum check-in age: 21

Check-out

Check-out before 11:00 AM
Contactless check-out available
Express check-out available

Special check-in instructions

Front desk staff will greet guests on arrival at the property
If you are planning to arrive after 11:00 PM please contact the property in advance using the information on the booking confirmation
The credit card used to book the reservation must be presented by the cardholder at check-in along with matching photo identification, and other arrangements must be coordinated with the property prior to arrival
Information provided by the property may be translated using automated translation tools

Access methods

Staffed front desk

Pets

Pets not allowed

Children and extra beds

Children are welcome
2 children, per adult, up to the age of 18 years, can stay for free if using existing beds when occupying the parent or guardian's room
Rollaway/extra beds are available for USD 50.00 per night
Free cribs are available on request at the property

Property payment types

Important information

Fees

You'll be asked to pay the following charges at the property. Fees may include applicable taxes:

  • Breakage deposit: USD 100 per day

We have included all charges provided to us by the property.

Optional extras

  • Fee for buffet breakfast: approximately USD 26.99 to 26.99 for adults, and USD 15 to 30 for children
  • Uncovered self parking fee: USD 12.00 per night
  • Rollaway bed fee: USD 50.00 per night

The above list may not be comprehensive. Fees and deposits may not include tax and are subject to change.

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
The name on the credit card used at check-in to pay for incidentals must be the primary name on the guestroom reservation
This property accepts credit cards and debit cards; cash is not accepted
This property reserves the right to pre-authorize the guest's credit card prior to arrival.
Cashless transactions are available
Safety features at this property include a carbon monoxide detector, a fire extinguisher, and a smoke detector

We should mention

Pool access available from 8:00 AM to 10:00 PM
Only registered guests are allowed in the guestrooms
A car is not required for transportation to and from this property
Guests under 21 years old are not allowed in the fitness facility, and guests under 16 years old are only allowed in the swimming pool with adult supervision
This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly)

Property is also known as

Hilton Jacksonville At Mayo Clinic Hotel
Hilton Jacksonville At Mayo Clinic Jacksonville
Hilton Jacksonville At Mayo Clinic Hotel Jacksonville

Frequently asked questions

Does Hilton Jacksonville At Mayo Clinic have a pool?

Yes, this property has an outdoor pool. Pool access is from 8:00 AM–10:00 PM.

Is Hilton Jacksonville At Mayo Clinic pet-friendly?

No, pets are not allowed at this property.

How much is parking?

Self parking is available for USD 12.00 per night.

What time is check-in at Hilton Jacksonville At Mayo Clinic?

Check-in start time: 4:00 PM; Check-in end time: 5:00 AM. Late check-in is available during limited hours.

What time is check-out at Hilton Jacksonville At Mayo Clinic?

Check-out is at 11:00 AM.

Where is Hilton Jacksonville At Mayo Clinic located?

Situated in Jacksonville, this luxury hotel is 0.3 mi (0.5 km) from Mayo Clinic Florida and within 6 mi (10 km) of Windsor Commons Shopping Center and Windsor Parke Golf Club. University of North Florida and Gonzales Park are also within 6 mi (10 km).

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Reviews

Hilton Jacksonville At Mayo Clinic Reviews

9.4

Exceptional

9.6

Cleanliness

9.4

Amenities

9.6

Staff & service

9.8

Property conditions & facilities
Rating 10 - Excellent. 173 out of 214 reviews
Rating 8 - Good. 20 out of 214 reviews
Rating 6 - Okay. 10 out of 214 reviews
Rating 4 - Poor. 6 out of 214 reviews
Rating 2 - Terrible. 5 out of 214 reviews

Reviews

Verified

10/10 Excellent

Jorge Miguel

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The staff and the location are great.
Stayed 1 night in Mar 2026
Verified

10/10 Excellent

Paul

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Property was very clean and convenient for access to Mayo Clinic.
Stayed 2 nights in Mar 2026
Verified

10/10 Excellent

Shaunte

Liked: Cleanliness, staff & service, amenities
The staff and hotel were wonderful!
Stayed 1 night in Jan 2026
Verified

10/10 Excellent

Maria Ines

Liked: Cleanliness, amenities, property conditions & facilities
Good restaurant, convenient location for Mayo Clinic, easy parking.
Stayed 3 nights in Jan 2026
Verified

10/10 Excellent

Schylea

Liked: Cleanliness, amenities, property conditions & facilities
Clean rooms, friendly staff close to Mayo Clinic.
Stayed 2 nights in Jan 2026
Verified

10/10 Excellent

Mark

Liked: Cleanliness, staff & service, amenities
Room was spotless, amenities were great, and staff was super nice!
Stayed 5 nights in Dec 2025
Verified

10/10 Excellent

Julie

Liked: Cleanliness, amenities, property conditions & facilities
Beautiful, clean, great atmosphere, very nice staff!
Stayed 2 nights in Dec 2025
Verified

10/10 Excellent

Daisy

Liked: Cleanliness, amenities, property conditions & facilities
Loved this hotel! Great location - friendly staff- yummy food and drinks at Coastal restaurant- hire and rooms are so nice and clean - pool and gym area were a plus! Coffee spot and shuttle also nice to have available.
Stayed 3 nights in Jan 2026
Verified

10/10 Excellent

Mark

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Newly opened so everything is great. Staff is very professional, friendly and accommodating. Room size is comfortable yet pretty standard. Just an FYI if sharing the room, the door to the bathroom does not lock it just slides closed.
Stayed 2 nights in Jan 2026
Verified

10/10 Excellent

Melissa

The rooms were clean. Bar staff were wonderful, great personalities.
Stayed 3 nights in Jan 2026
Verified

10/10 Excellent

Albert

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Great staff and rooms
Stayed 1 night in Oct 2025
Verified

10/10 Excellent

Erron

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Very nice hotel. Food is excellent and friendly staff.
Stayed 2 nights in Oct 2025
Verified

10/10 Excellent

Gary

Yes very clean beautiful and nice staff. Conveniently located to Mayo.
Stayed 2 nights in Dec 2025
Verified

10/10 Excellent

Joahnna

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Clean, comfortable, nice restaurant & coffee shop.
Stayed 3 nights in Oct 2025
Verified

10/10 Excellent

Mohsin

Liked: Cleanliness, amenities, property conditions & facilities
Newly constructed, very clean and well maintained. Great staff. Highly recommend.
Stayed 1 night in Jan 2026
Verified

10/10 Excellent

Christian

Liked: Cleanliness, property conditions & facilities
The hotel looks like brand new! Modern and clean.
Stayed 1 night in Jan 2026
Verified

10/10 Excellent

Victor

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Parking was safe. Only complaint is that Wi-Fi is free but cumbersome to get there. You have to join some Hilton club for free to get Wi-Fi. I didn’t bother as it seemed to invasive. Also paying for parking daily seems a bit much with the price of the room being what it is.
Stayed 3 nights in Apr 2026
Verified

10/10 Excellent

DEBORAH

Liked: Cleanliness, staff & service, amenities
Spotless rooms, very friendly service!
Stayed 4 nights in Oct 2025
Verified

10/10 Excellent

Samuel

Nice room
Stayed 2 nights in Oct 2025
Verified

10/10 Excellent

Catherine

Liked: Cleanliness, staff & service, amenities
Beautiful hotel! Very comfortable beds. Spotless!! Definitely recommend. A+++++
Stayed 1 night in Jan 2026
Verified

10/10 Excellent

michael

Liked: Cleanliness, amenities, property conditions & facilities
Room was great and spacious. hoteal and bar staff was very accomodating
Stayed 1 night in Dec 2025
Verified

8/10 Good

Tristan

Liked: Cleanliness, staff & service, amenities
The staff were courteous, the amenities fantastic. Only problem was a clump of hair from a previous guest found in the shower.
Stayed 1 night in Dec 2025
Verified

8/10 Good

Taylor

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Everything and everyone was wonderful! The room service food was excellent, and the breakfast buffet was great. The only downside was the AC. It took quite a while for the room to cool down, and there wasn’t much air circulation. Since we were only staying one night, we didn’t request a room change—but it’s something to be aware of.
Stayed 1 night in Mar 2026
Verified

10/10 Excellent

Cathy

Liked: Cleanliness, staff & service, amenities
Room was spotless, new hotel, wonderful friendly staff
Stayed 1 night in Oct 2025
Verified

10/10 Excellent

Carrie

Liked: Cleanliness, amenities, property conditions & facilities
Room was amazing. Staff friendly and very knowledgeable!
Stayed 1 night in Dec 2025