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Hilton Jacksonville At Mayo Clinic

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Breakfast, lunch and dinner served - Hilton Jacksonville At Mayo Clinic (Jacksonville)
Terrace/patio - Hilton Jacksonville At Mayo Clinic (Jacksonville)
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Lobby - Hilton Jacksonville At Mayo Clinic (Jacksonville)
Luxury
4.5 star property
9.4

Exceptional

Mayo Clinic sanctuary

Sunlight dances across the sparkling outdoor pool with loungers and umbrellas. Inside, Coastal Kitchen serves American cuisine with children's menu options. The concierge arranges services while guests enjoy convenient access to Mayo Clinic just steps away.

Popular amenities

  • Free WiFi
  • Air conditioning
  • Gym

Room options

Available filters for rooms
Showing 19 of 19 rooms

View all photos for Room, 1 King Bed

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 1 King Bed

9.0 out of 10
Wonderful
(8 reviews)
  • Sleeps 2
  • 1 King Bed
  • Free WiFi

View all photos for Deluxe Room, 1 King Bed (Water View)

View from room

Deluxe Room, 1 King Bed (Water View)

  • Water view
  • Sleeps 2
  • 1 King Bed
  • Free WiFi

View all photos for Deluxe Room, 1 King Bed, Accessible (Roll-In Shower)

View from room

Deluxe Room, 1 King Bed, Accessible (Roll-In Shower)

  • Sleeps 2
  • 1 King Bed
  • Free WiFi

View all photos for Junior Suite, 1 King Bed

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Junior Suite, 1 King Bed

  • Sleeps 4
  • 1 King Bed
  • Free WiFi

View all photos for Junior Suite, 1 King Bed, Corner

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Junior Suite, 1 King Bed, Corner

  • Sleeps 4
  • 1 King Bed
  • Free WiFi

View all photos for Junior Suite, 1 King Bed, Accessible (Roll-In Shower)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Junior Suite, 1 King Bed, Accessible (Roll-In Shower)

  • Sleeps 2
  • 1 King Bed
  • Free WiFi

View all photos for Junior Suite, 1 King Bed, Accessible (Roll-In Shower)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Junior Suite, 1 King Bed, Accessible (Roll-In Shower)

  • Sleeps 2
  • 1 King Bed
  • Free WiFi

View all photos for Suite, 1 King Bed, Accessible (Mobility & Hearing, Roll-In Shower)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Suite, 1 King Bed, Accessible (Mobility & Hearing, Roll-In Shower)

  • Sleeps 2
  • 1 King Bed
  • Free WiFi

View all photos for Room, 1 King Bed (Water View)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 1 King Bed (Water View)

9.0 out of 10
Wonderful
(2 reviews)
  • Water view
  • Sleeps 2
  • 1 King Bed
  • Free WiFi

View all photos for Room, 1 King Bed (Water View, Roll-In Shower)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 1 King Bed (Water View, Roll-In Shower)

  • Water view
  • Sleeps 2
  • 1 King Bed
  • Free WiFi

View all photos for Room, 1 King Bed, Accessible (Hearing)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 1 King Bed, Accessible (Hearing)

  • Sleeps 2
  • 1 King Bed
  • Free WiFi

View all photos for Room, 1 King Bed, Accessible (Roll-In Shower)

Room, 1 King Bed, Accessible (Roll-In Shower) | Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 1 King Bed, Accessible (Roll-In Shower)

  • Sleeps 2
  • 1 King Bed
  • Free WiFi

View all photos for Room, 1 King Bed, Accessible (Hearing)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 1 King Bed, Accessible (Hearing)

10.0 out of 10
Exceptional
(1 review)
  • Sleeps 2
  • 1 King Bed
  • Free WiFi

View all photos for Room, 2 Queen Beds

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 2 Queen Beds

9.6 out of 10
Exceptional
(25 reviews)
  • Sleeps 4
  • 2 Queen Beds
  • Free WiFi

View all photos for Room, 2 Queen Beds, Accessible (Water View, Hearing)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 2 Queen Beds, Accessible (Water View, Hearing)

  • Water view
  • Sleeps 4
  • 2 Queen Beds
  • Free WiFi

View all photos for Room, 2 Queen Beds, Accessible, Bathtub

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 2 Queen Beds, Accessible, Bathtub

10.0 out of 10
Exceptional
(2 reviews)
  • Sleeps 4
  • 2 Queen Beds
  • Free WiFi

View all photos for Room, 2 Queen Beds, Accessible (Hearing)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 2 Queen Beds, Accessible (Hearing)

9.0 out of 10
Wonderful
(2 reviews)
  • Sleeps 4
  • 2 Queen Beds
  • Free WiFi

View all photos for Room, 2 Queen Beds (Water View)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 2 Queen Beds (Water View)

10.0 out of 10
Exceptional
(1 review)
  • Water view
  • Sleeps 4
  • 2 Queen Beds
  • Free WiFi

View all photos for Room, 2 Queen Beds, Accessible, Bathtub (View)

Premium bedding, in-room safe, blackout drapes, iron/ironing board

Room, 2 Queen Beds, Accessible, Bathtub (View)

  • Sleeps 4
  • 2 Queen Beds
  • Free WiFi

About the neighborhood

Jacksonville is home to Hilton Jacksonville At Mayo Clinic. Players by the Sea and Beaches Museum & History Park are cultural highlights, and some of the area's landmarks include Ribault Monument and Fort Caroline National Memorial. Looking to enjoy an event or a game while in town? See what's going on at EverBank Stadium, or consider a night out at Hodges Stadium. Visit our Jacksonville travel guide
Map
4745 Transformation Way, Jacksonville, FL, 32224

What's nearby

  • Jacksonville_UniversityofNorthFlorida_6127797_04
    University of North Florida
    5 min drive - 5.2 miles
  • Jacksonville_StJohnsTownCenter_6127793_05
    St. Johns Town Center
    7 min drive - 7.5 miles
  • Golf Course
    TPC Sawgrass
    16 min drive - 8.5 miles
  • Mayport Naval Station
    Mayport Naval Station
    25 min drive - 12.0 miles
  • F/A-18 Hornets at NAS Jacksonville
    Jacksonville Naval Air Station
    28 min drive - 29.9 miles

Getting around

  • Jacksonville Station
    28 min drive
  • Jacksonville International Airport (JAX)
    33 min drive

Restaurants

  • Culver’s
    3 min drive
  • Circle K
    16 min walk
  • Starbucks
    3 min drive
  • Mayo Clinic - Employee Cafeteria
    14 min walk
  • M Brothers at Mayo
    14 min walk

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Property amenities

Internet

  • Available in all rooms: Free WiFi
  • In-room WiFi speed: 25+ Mbps
  • Available in some public areas: Free WiFi

Parking and transportation

  • Electric car charging station on site
  • Free area shuttle up to 350 yds
  • Uncovered self parking on site (USD 12 per night)

Food and drink

  • Daily buffet breakfast available 6:00 AM to 10:30 AM for a fee: USD 26.99 to 26.99 for adults and USD 15 to 30 for children
  • A bar/lounge
  • A restaurant

Restaurants on site

  • Coastal Kitchen
  • Coastal Kitchen Bar

Things to do

  • Gym
  • Outdoor pool
  • TV in common areas

Family friendly

  • Free area shuttle
  • Grocery/convenience store
  • In-room crib
  • Laundry facilities
  • Mini-fridge
  • Outdoor pool
  • Rollaway/extra bed (surcharge)

Conveniences

  • 24-hour front desk
  • ATM
  • Grocery/convenience store
  • Laundry facilities
  • Luggage storage

Guest services

  • Concierge services
  • Dry cleaning/laundry service
  • Housekeeping (daily)
  • Porter/bellhop
  • Proposal/romance packages
  • Wedding services

Business services

  • 12 meeting rooms
  • 20,000 square feet of conference space
  • Coworking space

Outdoors

  • Firepit
  • Outdoor furniture
  • Pool loungers
  • Pool umbrellas

Accessibility

  • Tile flooring in public areas

More

  • 1 building
  • 8 floors
  • Built in 2025
  • Comprehensive food waste policy
  • Locally sourced food prioritized
  • Smoking not allowed
  • Some LED lighting used
  • Traditional architecture
  • Vegetarian breakfast available
  • Vegetarian dining options

Room amenities

Bedroom

  • Blackout drapes
  • Free crib
  • Premium bedding
  • Rollaway/extra bed (surcharge)

Bathroom

  • Bathtub or shower
  • Hair dryer
  • Shampoo
  • Soap
  • Toilet paper
  • Towels provided

Entertainment

  • 55-inch smart TV with premium cable channels
  • Netflix
  • Streaming services

Food and drink

  • Coffee/tea maker
  • Free bottled water
  • Late-night room service
  • Mini-fridge

More

  • Air conditioning
  • Free local calls
  • Free long-distance calls
  • Heating
  • Iron/ironing board
  • Laptop-compatible safe
  • LED lighting
  • Mobile key entry
  • Phone
  • Recycling
  • Water-efficient showers
  • Water-efficient toilets

Policies

Check-in

Check-in start time: 4:00 PM; Check-in end time: 5:00 AM
Late check-in subject to availability
Minimum check-in age: 21

Check-out

Check-out before 11:00 AM
Contactless check-out available
Express check-out available

Special check-in instructions

Front desk staff will greet guests on arrival at the property
If you are planning to arrive after 11:00 PM please contact the property in advance using the information on the booking confirmation
The credit card used to book the reservation must be presented by the cardholder at check-in along with matching photo identification, and other arrangements must be coordinated with the property prior to arrival
Information provided by the property may be translated using automated translation tools

Access methods

Staffed front desk

Pets

Pets not allowed

Children and extra beds

Children are welcome
2 children, per adult, up to the age of 18 years, can stay for free if using existing beds when occupying the parent or guardian's room
Rollaway/extra beds are available for USD 50.00 per night
Free cribs are available on request at the property

Property payment types

Important information

Fees

You'll be asked to pay the following charges at the property. Fees may include applicable taxes:

  • Breakage deposit: USD 100 per day

We have included all charges provided to us by the property.

Optional extras

  • Fee for buffet breakfast: approximately USD 26.99 to 26.99 for adults, and USD 15 to 30 for children
  • Uncovered self parking fee: USD 12.00 per night
  • Rollaway bed fee: USD 50.00 per night

The above list may not be comprehensive. Fees and deposits may not include tax and are subject to change.

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
The name on the credit card used at check-in to pay for incidentals must be the primary name on the guestroom reservation
This property accepts credit cards and debit cards; cash is not accepted
This property reserves the right to pre-authorize the guest's credit card prior to arrival.
Cashless transactions are available
Safety features at this property include a carbon monoxide detector, a fire extinguisher, and a smoke detector

We should mention

Pool access available from 8:00 AM to 10:00 PM
Only registered guests are allowed in the guestrooms
A car is not required for transportation to and from this property
Guests under 21 years old are not allowed in the fitness facility, and guests under 16 years old are only allowed in the swimming pool with adult supervision
This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly)

Frequently asked questions

Does Hilton Jacksonville At Mayo Clinic have a pool?

Yes, this property has an outdoor pool. Pool access is from 8:00 AM–10:00 PM.

Is Hilton Jacksonville At Mayo Clinic pet-friendly?

No, pets are not allowed at this property.

How much is parking?

Self parking is available for USD 12.00 per night.

What time is check-in at Hilton Jacksonville At Mayo Clinic?

Check-in start time: 4:00 PM; Check-in end time: 5:00 AM. Late check-in is available during limited hours.

What time is check-out at Hilton Jacksonville At Mayo Clinic?

Check-out is at 11:00 AM.

Where is Hilton Jacksonville At Mayo Clinic located?

Situated in Jacksonville, this luxury hotel is 0.3 mi (0.5 km) from Mayo Clinic Florida and within 6 mi (10 km) of Windsor Commons Shopping Center and Windsor Parke Golf Club. University of North Florida and Gonzales Park are also within 6 mi (10 km).

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Reviews

Hilton Jacksonville At Mayo Clinic Reviews

9.4

Exceptional

9.8

Cleanliness

9.4

Amenities

9.8

Staff & service

9.8

Property conditions & facilities
Rating 10 - Excellent. 208 out of 258 reviews
Rating 8 - Good. 24 out of 258 reviews
Rating 6 - Okay. 13 out of 258 reviews
Rating 4 - Poor. 8 out of 258 reviews
Rating 2 - Terrible. 5 out of 258 reviews

Reviews

Verified

10/10 Excellent

christine

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Beautiful hotel!! It was extremely quiet and we all slept amazing!!
Stayed 1 night in May 2026
Verified

10/10 Excellent

Richard

Clean, modern and super location.
Stayed 1 night in May 2026
Verified

10/10 Excellent

DALARNA

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Beautiful, clean, easy to find. Within great distance to shopping and beaches!!!!
Stayed 2 nights in May 2026
Verified

10/10 Excellent

Guacayarima

Liked: Cleanliness, staff & service, property conditions & facilities
The most helpful and nicest staff. They go the extra mile to make your stay go smoothly.
Stayed 6 nights in Jun 2026
Verified

10/10 Excellent

Sandra

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
This is a beautiful hotel right next to May Clinic. We were there for a graduation party and the food was excellent, the staff was great and the room was spacious with all the amenities.
Stayed 2 nights in May 2026
Verified

10/10 Excellent

Jorge Miguel

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The staff and the location are great.
Stayed 1 night in Mar 2026
Verified

10/10 Excellent

shondeen

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The gym was amazing
Stayed 1 night in May 2026
Verified

10/10 Excellent

Mark

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Very friendly staff. New hotel so everything works and is clean and in good condition. Comfortable rooms. Some rooms don’t have a good view like the rooftop with AC equipment. Very modern look. It’s definitely my preferred place to stay in that area.
Stayed 5 nights in Apr 2026
Verified

10/10 Excellent

Shaunte

Liked: Cleanliness, staff & service, amenities
The staff and hotel were wonderful!
Stayed 1 night in Jan 2026
Verified

10/10 Excellent

Paul

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Property was very clean and convenient for access to Mayo Clinic.
Stayed 2 nights in Mar 2026
Verified

10/10 Excellent

Thomas

Liked: Cleanliness, staff & service, property conditions & facilities
Very clean and room was nice
Stayed 2 nights in Mar 2026
Verified

10/10 Excellent

Maria Ines

Liked: Cleanliness, amenities, property conditions & facilities
Good restaurant, convenient location for Mayo Clinic, easy parking.
Stayed 3 nights in Jan 2026
Verified

10/10 Excellent

Mark

Liked: Cleanliness, staff & service, amenities
Room was spotless, amenities were great, and staff was super nice!
Stayed 5 nights in Dec 2025
Verified

10/10 Excellent

Schylea

Liked: Cleanliness, amenities, property conditions & facilities
Clean rooms, friendly staff close to Mayo Clinic.
Stayed 2 nights in Jan 2026
Verified

10/10 Excellent

Julie

Liked: Cleanliness, amenities, property conditions & facilities
Beautiful, clean, great atmosphere, very nice staff!
Stayed 2 nights in Dec 2025
Verified

10/10 Excellent

Daisy

Liked: Cleanliness, amenities, property conditions & facilities
Loved this hotel! Great location - friendly staff- yummy food and drinks at Coastal restaurant- hire and rooms are so nice and clean - pool and gym area were a plus! Coffee spot and shuttle also nice to have available.
Stayed 3 nights in Jan 2026
Verified

10/10 Excellent

Mark

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Newly opened so everything is great. Staff is very professional, friendly and accommodating. Room size is comfortable yet pretty standard. Just an FYI if sharing the room, the door to the bathroom does not lock it just slides closed.
Stayed 2 nights in Jan 2026
Verified

10/10 Excellent

Melissa

The rooms were clean. Bar staff were wonderful, great personalities.
Stayed 3 nights in Jan 2026
Verified

10/10 Excellent

Albert

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Great staff and rooms
Stayed 1 night in Oct 2025
Verified

10/10 Excellent

Diane

Liked: Cleanliness, staff & service, amenities
Friendly welcoming staff at the front desk and the restaurant! Immaculate! Comfy bedding and pillows!
Stayed 1 night in Feb 2026
Verified

10/10 Excellent

Erron

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Very nice hotel. Food is excellent and friendly staff.
Stayed 2 nights in Oct 2025
Verified

10/10 Excellent

Gary

Yes very clean beautiful and nice staff. Conveniently located to Mayo.
Stayed 2 nights in Dec 2025
Verified

10/10 Excellent

Joahnna

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Clean, comfortable, nice restaurant & coffee shop.
Stayed 3 nights in Oct 2025
Verified

10/10 Excellent

Mohsin

Liked: Cleanliness, amenities, property conditions & facilities
Newly constructed, very clean and well maintained. Great staff. Highly recommend.
Stayed 1 night in Jan 2026
Verified

10/10 Excellent

Christian

Liked: Cleanliness, property conditions & facilities
The hotel looks like brand new! Modern and clean.
Stayed 1 night in Jan 2026