
Vacations Close To Florida Keys National Marine Sanctuary
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Florida Keys National Marine Sanctuary Flight + Hotel packages
Price found within the past 48 hours. Click for updated prices.


The Marker Key West Harbor Resort
Key West Historic District
Save 100% on your flight
Price was $3,403, price is now $2,284 per person
$2,284
per person
Dec 22 - Dec 29
found 8 hours ago
Roundtrip non-stop flight included
St. Louis (STL) to Key West (EYW)
Doesn't present in real life like it does online. Hallways were hot. Pools were very small and we felt like sardines in a bathtub. The room itself was styled well.
Reviewed on Nov 6, 2026

The Key West Hotel
Key West Historic District
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Price was $5,359, price is now $3,667 per person
$3,667
per person
Dec 22 - Dec 29
found 8 hours ago
Roundtrip non-stop flight included
St. Louis (STL) to Key West (EYW)
Clean, clean, clean. Hidden! Elite Backyard Oasis. Top Tier bar and fantastic nightly entertainment. If your traveling with anyone under 25, choose different. Will be back, no doubt!
Reviewed on Oct 29, 2026


Southernmost Beach Resort and Guesthouses
Old Town Key West
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Price was $3,155, price is now $2,285 per person
$2,285
per person
Dec 22 - Dec 29
found 8 hours ago
Roundtrip non-stop flight included
St. Louis (STL) to Key West (EYW)
I didn't like the fact that when I booked the trip, it didn't say that the room was 2 or 3 blocks from the original hotel that Iwas thinking I booked. We had to do the check in ourselves in the original hotel while others around us got it done by staff , we felt like we were discriminated . The staff didn't say to us where to have breakfast the next day , that of course it was on the original property and we had to go back the next morning. Nobody was on the second property to help you if you need something. The website showed one thing and the reality another completely different.
Reviewed on Nov 5, 2026


Southernmost House - Adult Exclusive
Old Town Key West
Save 100% on your flight
Price was $3,815, price is now $2,986 per person
$2,986
per person
Dec 22 - Dec 29
found 8 hours ago
Roundtrip non-stop flight included
St. Louis (STL) to Key West (EYW)
Our honeymoon stay was for one week. We will return again for one week for our first anniversary. Our bed linens were not changed every day. The temperature was 80°. The pool water was 85°. We were not sure why they kept the pool water so hot
Reviewed on Nov 5, 2026

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See all available trips from Columbus to Florida Keys National Marine Sanctuary
View all tripsBest Lodging Options Near Florida Keys National Marine Sanctuary

La Concha Key West, Autograph Collection
430 Duval St Key West FL
0.81 km from Florida Keys National Marine Sanctuary
Book a stay at this business-friendly hotel in Key West. Enjoy free WiFi, 3 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the clean ...

Southernmost Beach Resort and Guesthouses
1319 Duval Street Key West FL
1.14 km from Florida Keys National Marine Sanctuary
Book a stay at this spa hotel in Key West. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in our ...

The Southernmost Inn - Adults Only
525 United Street Key West FL
1.13 km from Florida Keys National Marine Sanctuary
Stay at this hotel in Key West. Enjoy free breakfast, 2 outdoor pools, and parking (surcharge). Our guests praise the breakfast and the pool in our reviews. ...

Tranquility Guest House
302 Angela st Key West FL
0.49 km from Florida Keys National Marine Sanctuary
Stay at this hotel in Key West. Enjoy free WiFi, a garden, and cable TV channels. Popular attractions Duval Street and Ernest Hemingway Home and Museum are located ...

Douglas House - Adults Only
419 Amelia St Key West FL
0.89 km from Florida Keys National Marine Sanctuary
Stay at this guesthouse in Key West. Enjoy free WiFi, daily housekeeping, and a garden. Popular attractions Duval Street and Mallory Square are located ...

Winslow's Bungalows - Key West Historic Inns
725 Truman Avenue Key West FL
1.18 km from Florida Keys National Marine Sanctuary
Stay at this hotel in Key West. Enjoy free WiFi, 3 outdoor pools, and breakfast (surcharge). Our guests praise the breakfast and the pool in our reviews. Popular ...
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See all available properties in Florida Keys National Marine Sanctuary
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

