Photo by Catherine Edejer-McCormick
Choose from 4807 Downtown South San Francisco Hotel Deals
La Quinta Inn & Suites by Wyndham San Francisco Airport N
20 Airport Blvd, South San Francisco, CA
1.03 km from Downtown South San Francisco
Stay at this business-friendly hotel in South San Francisco. Enjoy free breakfast, free WiFi, and a free airport shuttle. Our guests praise the breakfast and ...
Holiday Inn Golden Gateway, an IHG Hotel
1500 Van Ness Ave, San Francisco, CA
Free Cancellation
14.8 km from Downtown South San Francisco
Stay at this business-friendly hotel in San Francisco. Enjoy free WiFi, a 24-hour fitness center, and onsite parking. Our guests praise the pool and the helpful ...
Hotel Riu Plaza Fisherman's Wharf
2500 Mason St, San Francisco, CA
Free Cancellation
Reserve now, pay when you stay
16.69 km from Downtown South San Francisco
Stay at this business-friendly hotel in San Francisco. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
King George Hotel
334 Mason Street, San Francisco, CA
Free Cancellation
Reserve now, pay when you stay
14.47 km from Downtown South San Francisco
Stay at this hotel in San Francisco. Enjoy WiFi, a 24-hour front desk, and daily housekeeping. Our guests praise the helpful staff and the clean rooms in our ...
The Marker San Francisco
501 Geary St, San Francisco, CA
Free Cancellation
Reserve now, pay when you stay
14.44 km from Downtown South San Francisco
Stay at this boutique hotel in San Francisco. Enjoy breakfast, a 24-hour fitness center, and valet parking. Our guests praise the restaurant and the helpful ...
Hotel Caza Fisherman's Wharf
1300 Columbus Avenue, San Francisco, CA
Free Cancellation
Reserve now, pay when you stay
16.66 km from Downtown South San Francisco
Stay at this 4-star family-friendly hotel in San Francisco. Enjoy free WiFi, breakfast, and a 24-hour fitness center. Our guests praise the helpful staff and ...
Club Quarters Hotel in San Francisco
424 Clay St, San Francisco, CA
Free Cancellation
Reserve now, pay when you stay
15.43 km from Downtown South San Francisco
Stay at this 4-star business-friendly hotel in San Francisco. Enjoy free WiFi, breakfast, and room service. Our guests praise the restaurant and the helpful ...
Hyatt Centric Fisherman's Wharf San Francisco
555 N Point St, San Francisco, CA
Free Cancellation
16.62 km from Downtown South San Francisco
Stay at this business-friendly hotel in San Francisco. Enjoy free WiFi, breakfast, and a 24-hour fitness center. Our guests praise the pool and the restaurant ...
Hyatt Regency San Francisco
5 Embarcadero Center, San Francisco, CA
Free Cancellation
15.33 km from Downtown South San Francisco
Stay at this business-friendly hotel in San Francisco. Enjoy free WiFi, breakfast, and room service. Our guests praise the helpful staff and the clean rooms ...
Hotel Zephyr San Francisco
250 Beach Street, San Francisco, CA
Free Cancellation
16.77 km from Downtown South San Francisco
Stay at this 4-star boutique hotel in San Francisco. Enjoy free WiFi, a 24-hour fitness center, and valet parking. Our guests praise the helpful staff and the ...
Chancellor Hotel on Union Square
433 Powell St, San Francisco, CA
Free Cancellation
Reserve now, pay when you stay
14.69 km from Downtown South San Francisco
Stay at this business-friendly hotel in San Francisco. Enjoy free WiFi, a 24-hour front desk, and a business center. Our guests praise the helpful staff and ...
The Westin St. Francis San Francisco on Union Square
335 Powell Street, San Francisco, CA
Free Cancellation
Reserve now, pay when you stay
14.58 km from Downtown South San Francisco
Stay at this business-friendly hotel in San Francisco. Enjoy breakfast, WiFi, and room service. Our guests praise the helpful staff and the clean rooms in our ...
The Westin San Francisco Airport
1 Old Bayshore Hwy, Millbrae, CA
6.85 km from Downtown South San Francisco
Stay at this business-friendly hotel in Millbrae. Enjoy breakfast, WiFi, and a free airport shuttle. Our guests praise the pool and the helpful staff in our ...
Bay Landing San Francisco Airport Hotel
1550 Bayshore Hwy, Burlingame, CA
Free Cancellation
Reserve now, pay when you stay
7.85 km from Downtown South San Francisco
Stay at this 3-star business-friendly hotel in Burlingame. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
DoubleTree by Hilton Hotel Berkeley Marina
200 Marina Blvd, Berkeley, CA
Free Cancellation
Reserve now, pay when you stay
25.26 km from Downtown South San Francisco
Stay at this 4-star business-friendly hotel in Berkeley. Enjoy free WiFi, a marina, and breakfast. Our guests praise the pool and the restaurant in our reviews. ...
Hotel Nikko San Francisco
222 Mason St, San Francisco, CA
Free Cancellation
Reserve now, pay when you stay
14.35 km from Downtown South San Francisco
Stay at this hotel in San Francisco. Enjoy a nightclub, a rooftop terrace, and breakfast. Our guests praise the breakfast and the pool in our reviews. Popular ...
Don't see what you're looking for?
See all available properties in Downtown South San Francisco
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Downtown South San Francisco, San Francisco Hotel Guide
Search for hotels in Downtown South San Francisco on Expedia.com. You can easily find your hotels in Downtown South San Francisco using one of the methods below:
- View our selection of featured hotels in Downtown South San Francisco
- Use the map to find hotels in the Downtown South San Francisco neighborhood you prefer
- Use the filters to see hotels in a specific area of Downtown South San Francisco, select a specific theme, brand, or hotel class from basic (1 Star) to luxury hotels (5 Stars) in Downtown South San Francisco
- Enter your travel dates to view the best deals on hotels in Downtown South San Francisco - while they last
More Downtown South San Francisco Hotel Deals for Seniors and Members
- La Quinta Inn & Suites by Wyndham San Francisco Airport N
- Holiday Inn Golden Gateway, an IHG Hotel
- Hotel Riu Plaza Fisherman's Wharf
- King George Hotel
- The Marker San Francisco
- Hotel Caza Fisherman's Wharf
- Club Quarters Hotel in San Francisco
- Hyatt Centric Fisherman's Wharf San Francisco
- Hyatt Regency San Francisco
- Hotel Zephyr San Francisco