Cheap 2024 Downtown South San Francisco Hotels

Photo by Catherine Edejer-McCormick

Choose from 4807 Downtown South San Francisco Hotel Deals

Don't see what you're looking for?
See all available properties in Downtown South San Francisco
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Downtown South San Francisco, San Francisco Hotel Guide

Search for hotels in Downtown South San Francisco on Expedia.com. You can easily find your hotels in Downtown South San Francisco using one of the methods below:

  • View our selection of featured hotels in Downtown South San Francisco
  • Use the map to find hotels in the Downtown South San Francisco neighborhood you prefer
  • Use the filters to see hotels in a specific area of Downtown South San Francisco, select a specific theme, brand, or hotel class from basic (1 Star) to luxury hotels (5 Stars) in Downtown South San Francisco
  • Enter your travel dates to view the best deals on hotels in Downtown South San Francisco - while they last