Defiance, MO

Travel Guide

A rustic covered bridge with a wooden structure and red accents, surrounded by lush greenery and trees.
A calm lake with a solitary tree on a small island, surrounded by a forested shoreline.
A wooden dock extending into a pond with lily pads, surrounded by lush greenery and a clear blue sky.
A restaurant with outdoor seating and a blue sign.
A glass of red wine on a wooden table with a vineyard in the background.
Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis

3.5 out of 5
777 Casino Center Drive Maryland Heights MO
Book a stay at this business-friendly hotel in Maryland Heights. Enjoy free parking, 7 restaurants, and a casino. Our guests praise the helpful staff and the ...
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Hollywood Casino & Hotel St. Louis
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

3 out of 5
1088 South Highway Drive Fenton MO
Book a stay at this business-friendly hotel in Fenton. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
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Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
The Wildwood Hotel

The Wildwood Hotel

3.5 out of 5
2801 Fountain Pl Wildwood MO
Book a stay at this business-friendly hotel in Wildwood. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the convenient ...
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The Wildwood Hotel
See all 877 properties in Defiance
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Defiance attractions

A glass of red wine on a wooden table with a vineyard in the background.
Photo by Pages of Travel
Open Photo by Pages of Travel

Chandler Hill Vineyards

7.8/5 (7 reviews)
You can enjoy a tasting or tour at Chandler Hill Vineyards during your travels to Defiance. While in this romantic area, you can savor the top-notch restaurants.
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Things to do

Pappy's Smokehouse

Private Tour of St. Louis's Iconic BBQ Joints & Breweries

$129
per adult
Private Tour of St. Louis's Iconic BBQ Joints & Breweries
Best of St. Louis Small Group Tour w/ Arch & River Cruise

St. Louis Premium Small Group Tour With Arch & River Cruise

$161
per adult
84% of travellers recommend
St. Louis Premium Small Group Tour With Arch & River Cruise
Lemp Haunted Neighborhood Walking Tour

Lemp Haunted Neighborhood Walking Tour

$25
per adult
84% of travellers recommend
Lemp Haunted Neighborhood Walking Tour
St. Louis: Gateway Ghouls and Hauntings Walking Tour

St. Louis Ghost Tour: Sinister Sins & Shadows

$24
per adult
100% of travellers recommend
St. Louis Ghost Tour: Sinister Sins & Shadows
St Louis Self-Guided Driving and Walking Audio Tour

St Louis Self-Guided Driving and Walking Audio Tour

$17
per traveler
St Louis Self-Guided Driving and Walking Audio Tour
St. Louis Premium Driving Tour with Boat Ride & Arch

St. Louis Premium Driving Tour with Boat Ride & Arch

$174
per adult
100% of travellers recommend
St. Louis Premium Driving Tour with Boat Ride & Arch
See all activities in Defiance

Cities near Defiance

A forested cliff with autumn foliage and a clear sky.

Wentzville

A town with a prominent church spire, residential buildings, and a hill in the background.

Chesterfield

A calm lake reflecting trees with autumn foliage, a clear sky, and a distant shoreline.

St. Charles

A city skyline with a prominent arch bridge and a lit bridge over a calm river reflecting city lights.

O'Fallon