Defiance, MO

Travel Guide

A rustic covered bridge with a wooden structure and red accents, surrounded by lush greenery and trees.
A wooden dock extending into a pond with lily pads, surrounded by lush greenery and a clear blue sky.
A glass of red wine on a wooden table with a vineyard in the background.
A calm lake with a solitary tree on a small island, surrounded by a forested shoreline.
A restaurant with outdoor seating and a blue sign.
Sonesta ES Suites St. Louis - Chesterfield

Sonesta ES Suites St. Louis - Chesterfield

3 out of 5
15431 Conway Rd Chesterfield MO
Stay at this hotel in Chesterfield. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. ...
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Sonesta ES Suites St. Louis - Chesterfield
Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis

3.5 out of 5
777 Casino Center Drive Maryland Heights MO
Book a stay at this business-friendly hotel in Maryland Heights. Enjoy free parking, 7 restaurants, and a casino. Our guests praise the helpful staff and the ...
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Hollywood Casino & Hotel St. Louis
Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa

4.5 out of 5
1 Ameristar Blvd St. Charles MO
Book a stay at this luxury hotel in St. Charles. Enjoy a full-service spa, 6 restaurants, and a casino. Our guests praise the clean rooms in our reviews. Popular ...
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Ameristar Casino Resort and Spa
See all 896 properties in Defiance
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Defiance attractions

Chandler Hill Vineyards

7.8/10 (7 reviews)
You can enjoy a tasting or tour at Chandler Hill Vineyards during your travels to Defiance. While in this romantic area, you can savor the top-notch restaurants.
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Things to do

St. Louis Burlesque & Nightlife Experience at The Boom Boom Room

St. Louis Burlesque & Nightlife Experience at The Boom Boom Room

$60
per adult
100% of travellers recommend
St. Louis Burlesque & Nightlife Experience at The Boom Boom Room
St. Louis & Gateway Arch NP Self Guided Walk & Drive Audio Tour

St. Louis & Gateway Arch NP Self Guided Walk & Drive Audio Tour

$17
per traveler
St. Louis & Gateway Arch NP Self Guided Walk & Drive Audio Tour
Landmarks Downtown-East Walking Tour

Landmarks Downtown-East Walking Tour

$20
per adult
Landmarks Downtown-East Walking Tour
Pappy's Smokehouse

Private Tour of St. Louis's Iconic BBQ Joints & Breweries

$139
per adult
Private Tour of St. Louis's Iconic BBQ Joints & Breweries
St. Louis: Museum of Illusions Entry Ticket

St. Louis: Museum of Illusions Entry Ticket

$35
per adult
92% of travellers recommend
St. Louis: Museum of Illusions Entry Ticket
St. Louis: Gateway Ghouls and Hauntings Walking Tour

St. Louis Ghost Tour: Sinister Sins & Shadows

$24
per adult
100% of travellers recommend
St. Louis Ghost Tour: Sinister Sins & Shadows
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Cities near Defiance

A frozen lake with a sunset and a forest in the background.

Wentzville

A city skyline with a prominent arch bridge and a lit bridge over a calm river reflecting city lights.

Chesterfield

A bridge over a calm river with a sunset sky.

St. Charles

A city skyline with a prominent arch bridge and a lit bridge over a calm river reflecting city lights.

O'Fallon