Defiance, MO

Travel Guide

A covered bridge at the Historic Daniel Boone Home Park in Defiance, Missouri

Wetlands landscape with a bird blind and cloudy sky reflected in a lake at the August A. Busch Memorial Conservation Area in St. Charles County Missouri

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Things to do

Defiance Hotel Deals

Hollywood Casino & Hotel St. Louis

777 Casino Center Drive Maryland Heights MO

Book a stay at this business-friendly hotel in Maryland Heights. Enjoy free parking, 7 restaurants, and a casino. Our guests praise the helpful staff and the ...

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Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

1088 South Highway Drive Fenton MO

Book a stay at this business-friendly hotel in Fenton. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...

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The Wildwood Hotel

2801 Fountain Pl Wildwood MO

Book a stay at this business-friendly hotel in Wildwood. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the convenient ...

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See all 876 properties in Defiance

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit

St. Louis Union Station

4/5(625 reviews)

You can learn about the local history of St. Louis when you make a stop at a well-known site like St. Louis Union Station. Experience the area's great live music or attend a baseball game.

Busch Stadium

4.5/5(1,487 reviews)

Catch an event at Busch Stadium during your trip to St. Louis. Experience the area's acclaimed theater scene or attend a baseball game.

Gateway Arch

4.5/5(2,542 reviews)

Find out about the history of Gateway Arch, one of the top monuments in St. Louis. Experience the area's fascinating museums or attend a baseball game.

Enterprise Center

4.5/5(493 reviews)

Catch an event at Enterprise Center during your trip to St. Louis. Experience the area's great live music or attend a baseball game.

St. Louis Zoo

4.5/5(1,225 reviews)

Why not visit the animals who live at St. Louis Zoo and see why this is a popular attraction in St. Louis? Amble around the area's lush forest or attend a sporting event.