Clayton Vacation Packages for 2025
Build a Flight + Hotel Bundle & Save up to $536 On Your Vacation*
Top Hotel Deals
Clayton Plaza Hotel & Extended Stay
7750 Carondelet Avenue, St. Louis, MO
1.34 km from Clayton
Stay at this 3.5-star business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and ...
Le Méridien St. Louis Clayton
7730 Bonhomme Ave, St. Louis, MO
1.21 km from Clayton
Book a stay at this eco-certified hotel in St. Louis. Enjoy an outdoor pool, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
AC Hotel St. Louis Clayton
227 South Central Ave, St. Louis, MO
1.41 km from Clayton
Stay at this 3-star business-friendly hotel in St. Louis. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Popular attractions St. Louis Zoo and Forest Park ...
Hampton Inn & Suites Clayton/St. Louis-Galleria Area
216 N Meramec Ave, St. Louis, MO
1.89 km from Clayton
Stay at this 3-star business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the helpful staff in our reviews. ...
Hyatt Regency St. Louis at The Arch
315 Chestnut St, St. Louis, MO
11.95 km from Clayton
Stay at this 4-star business-friendly hotel in St. Louis. Enjoy free WiFi, 3 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the clean ...
Drury Plaza Hotel St. Louis at the Arch
2 South 4th Street, St. Louis, MO
11.88 km from Clayton
Stay at this 3-star business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the pool ...
Pear Tree Inn St. Louis Airport
10810 Pear Tree Ln, St. Ann, MO
11.49 km from Clayton
Book a stay at this business-friendly hotel in St. Ann. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
Hollywood Casino & Hotel St. Louis
777 Casino Center Drive, Maryland Heights, MO
18.34 km from Clayton
Book a stay at this business-friendly hotel in Maryland Heights. Enjoy free parking, 7 restaurants, and a casino. Our guests praise the helpful staff and the ...
Casino Queen Hotel
200 Front Street, East St. Louis, IL
13 km from Clayton
Stay at this 3-star business-friendly hotel in East St. Louis. Enjoy free WiFi, free parking, and a casino. Our guests praise the helpful staff and the clean ...
Moonrise Hotel
6177 Delmar Blvd, St. Louis, MO
2.59 km from Clayton
Stay at this 4-star boutique hotel in St. Louis. Enjoy free WiFi, free parking, and 2 bars/lounges. Our guests praise the restaurant and the bar in our reviews. ...
Wingate by Wyndham St. Louis Airport
10820 Pear Tree Lane, St. Ann, MO
11.48 km from Clayton
Book a stay at this business-friendly hotel in St. Ann. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
DoubleTree by Hilton St. Louis Airport
4505 Woodson Road, St. Louis, MO
10.49 km from Clayton
Stay at this 4-star family-friendly hotel in St. Louis. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and the ...
Drury Inn & Suites St. Louis Union Station
201 S 20th St, St. Louis, MO
10.03 km from Clayton
Book a stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top Flight Deals
These prices were available within the past 7 days. Prices quoted are per person, round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.
Mon, Jul 14 - Mon, Jul 21
EWR
Newark Liberty Intl. Airport
STL
Lambert-St. Louis Intl.
$141 Roundtrip, found 1 day ago
$141
Roundtrip
found 1 day ago
Thu, Jul 10 - Thu, Jul 17
TPA
Tampa Intl.
STL
Lambert-St. Louis Intl.
$169 Roundtrip, found 2 days ago
$169
Roundtrip
found 2 days ago
Wed, Sep 24 - Mon, Sep 29
PHL
Philadelphia Intl.
STL
Lambert-St. Louis Intl.
$174 Roundtrip, found 8 hours ago
$174
Roundtrip
found 8 hours ago
Thu, Aug 28 - Sun, Sep 14
DFW
Dallas-Fort Worth Intl.
STL
Lambert-St. Louis Intl.
$176 Roundtrip, found 3 days ago
$176
Roundtrip
found 3 days ago
Best points of interest in St. Louis
- Chapel of St. Timothy And St. Titus Vacations
- Busch Stadium Vacations
- Enterprise Center Vacations
- St. Louis Union Station Vacations
- St. Louis Zoo Vacations
- Gateway Arch Vacations
- Washington University in St. Louis Vacations
- City Museum Vacations
- Dome at America’s Center Vacations
- Hollywood Casino Amphitheatre Vacations
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More Types of Hotels
- Hotels with Bars in Clayton
- Hotels with WiFi in Clayton
- Hotels with Air Conditioning in Clayton
- Family Hotels in Clayton
- Hotels with a Pool in Clayton
- Hotels with Hot Tubs in Clayton
- Hotel with a Concierge in Clayton
- Hotels with Complimentary Breakfast in Clayton
- Hotel with wifi in Clayton
- Luxury Hotels in Clayton
- Hotels with Balconies in Clayton
- Cheap Hotels in Clayton
- Resorts & Hotels with Spas in Clayton
- Smoke Free Hotels in Clayton
- Hotels with an Indoor Pool in Clayton
- Pet-friendly Hotels in Clayton
- Hotels with Free Airport Shuttle in Clayton
- Hotels with Tennis Courts in Clayton