Clayton Vacation Packages for 2026
Build a Flight + Hotel Bundle & Save up to $536 On Your Vacation*
Clayton Flight + Hotel packages
Price found within the past 48 hours. Click for updated prices.
Crowne Plaza St. Louis Airport by IHG
Price was $507, price is now $396 per person
$396
per person
May 16 - May 20
found 22 hours ago
Roundtrip flight included
Detroit (DTW) to St. Louis (STL)
Book a stay at this business-friendly hotel in Bridgeton. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful staff in our reviews. Popular attractions Hollywood Casino Amphitheatre and Ameristar Casino St. Charles are located nearby.
The Cheshire
Save 100% on your flight
Price was $810, price is now $592 per person
$592
per person
May 16 - May 20
found 22 hours ago
Roundtrip flight included
Detroit (DTW) to St. Louis (STL)
Book a stay at this boutique hotel in Richmond Heights. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions St. Louis Zoo and St. Louis Union Station are located nearby.
Angad Arts Hotel St. Louis, Tapestry Collection by Hilton
Grand Center
Save 100% on your flight
Price was $808, price is now $591 per person
$591
per person
May 16 - May 20
found 22 hours ago
Roundtrip flight included
Detroit (DTW) to St. Louis (STL)
Book a stay at this business-friendly hotel in St. Louis. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions St. Louis Union Station and Enterprise Center are located nearby.
Hilton Garden Inn Chesterfield
Price was $547, price is now $404 per person
$404
per person
May 16 - May 20
found 22 hours ago
Roundtrip flight included
Detroit (DTW) to St. Louis (STL)
Book a stay at this business-friendly hotel in Chesterfield. Enjoy free WiFi, free parking, and breakfast (surcharge). Popular attractions The J - Chesterfield Gym & Fitness Center and Topgolf are located nearby.
HoteLumiere at the Arch - A Caesars Rewards Destination
Downtown St. Louis
Price was $590, price is now $439 per person
$439
per person
May 16 - May 20
found 22 hours ago
Roundtrip flight included
Detroit (DTW) to St. Louis (STL)
Book a stay at this business-friendly hotel in St. Louis. Enjoy 3 restaurants, a casino, and a 24-hour front desk. Our guests praise the clean rooms in our reviews. Popular attractions Gateway Arch and Busch Stadium are located nearby.
Ameristar Casino Resort and Spa
Price was $760, price is now $574 per person
$574
per person
May 16 - May 20
found 22 hours ago
Roundtrip flight included
Detroit (DTW) to St. Louis (STL)
Book a stay at this luxury hotel in St. Charles. Enjoy an outdoor pool, a full-service spa, and 6 restaurants. Our guests praise the clean rooms in our reviews. Popular attractions Ameristar Casino St. Charles and Hollywood Casino Amphitheatre are located nearby.
Top Hotel Deals
Clayton Plaza Hotel & Extended Stay
7750 Carondelet Avenue St. Louis MO
1.34 km from Clayton
Book a stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and ...
The Ritz-Carlton, St. Louis
100 Carondelet Plaza St. Louis MO
0.95 km from Clayton
Book a stay at this luxury hotel in St. Louis. Enjoy 2 restaurants, 3 bars/lounges, and breakfast (surcharge). Our guests praise the helpful staff and the room ...
Le Méridien St. Louis Clayton
7730 Bonhomme Ave St. Louis MO
1.21 km from Clayton
Book a stay at this business-friendly hotel in St. Louis. Enjoy an outdoor pool, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
AC Hotel St. Louis Clayton
227 South Central Ave St. Louis MO
1.41 km from Clayton
Book a stay at this business-friendly hotel in St. Louis. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Popular attractions St. Louis Zoo and Forest Park ...
Hampton Inn & Suites Clayton/St. Louis-Galleria Area
216 N Meramec Ave St. Louis MO
1.89 km from Clayton
Book a stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, a fitness center, and parking (surcharge). Our guests praise the helpful staff ...
Homewood Suites by Hilton St Louis - Galleria
8040 Clayton Road Richmond Heights MO
1.86 km from Clayton
Book a stay at this business-friendly hotel in Richmond Heights. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the helpful ...
Drury Plaza Hotel St. Louis at the Arch
2 South 4th Street St. Louis MO
11.89 km from Clayton
Book a stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and 2 hot tubs. Our guests praise the breakfast and the pool in our ...
Pear Tree Inn St. Louis Near Union Station
2211 Market Street St. Louis MO
9.77 km from Clayton
Book a stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the restaurant ...
21C Museum Hotel St Louis
1528 Locust street St. Louis MO
10.6 km from Clayton
Book a stay at this luxury hotel in St. Louis. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the pool and the restaurant in our ...
Hyatt Regency St. Louis at The Arch
315 Chestnut St St. Louis MO
11.95 km from Clayton
Book a stay at this business-friendly hotel in St. Louis. Enjoy free WiFi, 3 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the clean ...
Hollywood Casino & Hotel St. Louis
777 Casino Center Drive Maryland Heights MO
18.34 km from Clayton
Book a stay at this business-friendly hotel in Maryland Heights. Enjoy free parking, 7 restaurants, and a casino. Our guests praise the helpful staff and the ...
Pear Tree Inn St. Louis Airport
10810 Pear Tree Ln St. Ann MO
11.49 km from Clayton
Book a stay at this business-friendly hotel in St. Ann. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
Drury Inn & Suites St. Louis Union Station
201 S 20th St St. Louis MO
10.03 km from Clayton
Book a stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top Flight Deals
These prices were available within the past 7 days. Prices quoted are per person, round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.
Wed, May 27 - Wed, Jun 3
DEN
Denver Intl.
STL
Lambert-St. Louis Intl.
$78 Roundtrip, found 4 days ago
$78
Roundtrip
found 4 days ago
Thu, May 28 - Wed, Jun 3
DEN
Denver Intl.
STL
Lambert-St. Louis Intl.
$221 Roundtrip, found 12 hours ago
$221
Roundtrip
found 12 hours ago
Thu, May 28 - Wed, Jun 3
DEN
Denver Intl.
STL
Lambert-St. Louis Intl.
$221 Roundtrip, found 12 hours ago
$221
Roundtrip
found 12 hours ago
Mon, Jun 8 - Tue, Jun 9
SEA
Seattle - Tacoma Intl.
STL
Lambert-St. Louis Intl.
$299 Roundtrip, found 4 days ago
$299
Roundtrip
found 4 days ago
Mon, Jun 8 - Tue, Jun 9
SEA
Seattle - Tacoma Intl.
STL
Lambert-St. Louis Intl.
$407 Roundtrip, found 4 days ago
$407
Roundtrip
found 4 days ago