Clayton Vacation Packages for 2025

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Top Hotel Deals

Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay

3.5 out of 5
7750 Carondelet Avenue, St. Louis, MO
1.34 km from Clayton
Stay at this 3.5-star business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and ...
AC Hotel St. Louis Clayton

AC Hotel St. Louis Clayton

3 out of 5
227 South Central Ave, St. Louis, MO
1.41 km from Clayton
Stay at this 3-star business-friendly hotel in St. Louis. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Popular attractions St. Louis Zoo and Forest Park ...
The Ritz-Carlton, St. Louis

The Ritz-Carlton, St. Louis

5 out of 5
100 Carondelet Plaza, St. Louis, MO
0.95 km from Clayton
Stay at this 5-star luxury hotel in St. Louis. Enjoy breakfast (surcharge), room service, and a fitness center. Our guests praise the helpful staff and the room ...
Le Méridien St. Louis Clayton

Le Méridien St. Louis Clayton

4 out of 5
7730 Bonhomme Ave, St. Louis, MO
1.21 km from Clayton
Book a stay at this eco-certified hotel in St. Louis. Enjoy an outdoor pool, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
Hampton Inn & Suites Clayton/St. Louis-Galleria Area

Hampton Inn & Suites Clayton/St. Louis-Galleria Area

3 out of 5
216 N Meramec Ave, St. Louis, MO
1.89 km from Clayton
Stay at this 3-star business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the helpful staff in our reviews. ...
Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch

4 out of 5
315 Chestnut St, St. Louis, MO
11.95 km from Clayton
Stay at this 4-star business-friendly hotel in St. Louis. Enjoy free WiFi, 3 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the clean ...
Renaissance St. Louis Airport Hotel

Renaissance St. Louis Airport Hotel

4 out of 5
9801 Natural Bridge Road, St. Louis, MO
10.06 km from Clayton
Stay at this 4-star business-friendly hotel in St. Louis. Enjoy an outdoor pool, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful ...
Drury Plaza Hotel St. Louis at the Arch

Drury Plaza Hotel St. Louis at the Arch

3 out of 5
2 South 4th Street, St. Louis, MO
11.88 km from Clayton
Stay at this 3-star business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the pool ...
Pear Tree Inn St. Louis Airport

Pear Tree Inn St. Louis Airport

2.5 out of 5
10810 Pear Tree Ln, St. Ann, MO
11.49 km from Clayton
Book a stay at this business-friendly hotel in St. Ann. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis

3.5 out of 5
777 Casino Center Drive, Maryland Heights, MO
18.34 km from Clayton
Book a stay at this business-friendly hotel in Maryland Heights. Enjoy free parking, 7 restaurants, and a casino. Our guests praise the helpful staff and the ...
The Arch Convention Hotel

The Arch Convention Hotel

3.5 out of 5
811 N 9th Street, St. Louis, MO
11.43 km from Clayton
Stay at this 3.5-star business-friendly hotel in St. Louis. Enjoy free WiFi, a 24-hour fitness center, and parking (surcharge). Our guests praise the helpful ...
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

3 out of 5
1088 South Highway Drive, Fenton, MO
16.72 km from Clayton
Stay at this 3-star business-friendly hotel in Fenton. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

4 out of 5
421 N 8th St, St. Louis, MO
11.53 km from Clayton
Stay at this 4-star business-friendly hotel in St. Louis. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the bar and the helpful ...
Marriott St. Louis Grand

Marriott St. Louis Grand

4 out of 5
800 Washington Ave, St. Louis, MO
11.55 km from Clayton
Stay at this 4-star business-friendly hotel in St. Louis. Enjoy breakfast (surcharge), 24-hour room service, and a 24-hour fitness center. Our guests praise ...
Moonrise Hotel

Moonrise Hotel

4 out of 5
6177 Delmar Blvd, St. Louis, MO
2.59 km from Clayton
Stay at this 4-star boutique hotel in St. Louis. Enjoy free WiFi, free parking, and 2 bars/lounges. Our guests praise the restaurant and the bar in our reviews. ...
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Flight Deals

These prices were available within the past 7 days. Prices quoted are per person, round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Frontier Airlines
Wed, Oct 8 - Sat, Oct 11
DEN
Denver Intl.
STL
Lambert-St. Louis Intl.
$103 Roundtrip, found 14 hours ago
$103
Roundtrip
found 14 hours ago
Select Frontier Airlines flight, departing Wed, Oct 8 from Denver Intl. to Lambert-St. Louis Intl., returning Sat, Oct 11, priced at $103 found 14 hours ago
American Airlines
Wed, Oct 15 - Sun, Oct 19
TPA
Tampa Intl.
STL
Lambert-St. Louis Intl.
$175 Roundtrip, found 3 days ago
$175
Roundtrip
found 3 days ago
Select American Airlines flight, departing Wed, Oct 15 from Tampa Intl. to Lambert-St. Louis Intl., returning Sun, Oct 19, priced at $175 found 3 days ago
Spirit Airlines
Tue, Oct 14 - Tue, Oct 21
TPA
Tampa Intl.
STL
Lambert-St. Louis Intl.
$185 Roundtrip, found 3 days ago
$185
Roundtrip
found 3 days ago
Select Spirit Airlines flight, departing Tue, Oct 14 from Tampa Intl. to Lambert-St. Louis Intl., returning Tue, Oct 21, priced at $185 found 3 days ago
Delta
Sat, Oct 18 - Mon, Oct 20
TPA
Tampa Intl.
STL
Lambert-St. Louis Intl.
$197 Roundtrip, found 3 days ago
$197
Roundtrip
found 3 days ago
Select Delta flight, departing Sat, Oct 18 from Tampa Intl. to Lambert-St. Louis Intl., returning Mon, Oct 20, priced at $197 found 3 days ago
United
Sat, Sep 13 - Wed, Sep 17
EWR
Newark Liberty Intl. Airport
STL
Lambert-St. Louis Intl.
$256 Roundtrip, found 6 days ago
$256
Roundtrip
found 6 days ago
Select United flight, departing Sat, Sep 13 from Newark Liberty Intl. Airport to Lambert-St. Louis Intl., returning Wed, Sep 17, priced at $256 found 6 days ago