2026 4 Star Hotels in Lake Nona Medical City

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Featured Lake Nona Medical City 4 Star Hotels

DoubleTree by Hilton at the Entrance to Universal Orlando

DoubleTree by Hilton at the Entrance to Universal Orlando

4 out of 5
5780 Major Blvd Orlando FL
Fully refundable
DoubleTree by Hilton at the Entrance to Universal Orlando
Hyatt Regency Orlando International Airport

Hyatt Regency Orlando International Airport

4 out of 5
9300 Jeff Fuqua Boulevard Orlando FL
Fully refundableReserve now, pay when you stay
Hyatt Regency Orlando International Airport
Hyatt Regency Orlando

Hyatt Regency Orlando

4.5 out of 5
9801 International Dr Orlando FL
Fully refundableReserve now, pay when you stay
Hyatt Regency Orlando
Walt Disney World Dolphin

Walt Disney World Dolphin

4 out of 5
1500 Epcot Resort Blvd Lake Buena Vista FL
Fully refundableReserve now, pay when you stay
Walt Disney World Dolphin
Sheraton Vistana Resort Villas, Lake Buena Vista/Orlando

Sheraton Vistana Resort Villas, Lake Buena Vista/Orlando

4 out of 5
8800 Vistana Centre Dr Orlando FL
Sheraton Vistana Resort Villas, Lake Buena Vista/Orlando
Hilton Orlando Lake Buena Vista - Disney Springs® Area

Hilton Orlando Lake Buena Vista - Disney Springs® Area

4 out of 5
1751 Hotel Plaza Blvd Lake Buena Vista FL
Fully refundableReserve now, pay when you stay
Hilton Orlando Lake Buena Vista - Disney Springs® Area
DoubleTree by Hilton Hotel Orlando at SeaWorld

DoubleTree by Hilton Hotel Orlando at SeaWorld

4 out of 5
10100 International Drive Orlando FL
Fully refundableReserve now, pay when you stay
DoubleTree by Hilton Hotel Orlando at SeaWorld
Sheraton Vistana Villages Resort Villas, I-Drive/Orlando

Sheraton Vistana Villages Resort Villas, I-Drive/Orlando

4 out of 5
12401 International Dr Orlando FL
Sheraton Vistana Villages Resort Villas, I-Drive/Orlando
Courtyard by Marriott Lake Buena Vista at Vista Centre

Courtyard by Marriott Lake Buena Vista at Vista Centre

4 out of 5
8501 Palm Pkwy Orlando FL
Fully refundableReserve now, pay when you stay
Courtyard by Marriott Lake Buena Vista at Vista Centre
See all 27,672 properties in Lake Nona Medical City
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.