2025 4 Star Hotels in Downtown Syracuse

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Featured Downtown Syracuse 4 Star Hotels

Marriott Syracuse Downtown

Marriott Syracuse Downtown

4 out of 5
100 East Onondaga Street Syracuse NY
Fully refundableReserve now, pay when you stay
Marriott Syracuse Downtown
DoubleTree by Hilton Hotel Syracuse

DoubleTree by Hilton Hotel Syracuse

4 out of 5
6301 Route 298 East Syracuse NY
Fully refundableReserve now, pay when you stay
DoubleTree by Hilton Hotel Syracuse
Mirbeau Inn and Spa

Mirbeau Inn and Spa

4 out of 5
851 West Genesee Street Skaneateles NY
Fully refundableReserve now, pay when you stay
Mirbeau Inn and Spa
Skaneateles Fields Resort & Spa, Curio Collection By Hilton

Skaneateles Fields Resort & Spa, Curio Collection By Hilton

4 out of 5
1000 Mottville Road Skaneateles NY
Fully refundableReserve now, pay when you stay
Skaneateles Fields Resort & Spa, Curio Collection By Hilton
The Brewster Inn

The Brewster Inn

4 out of 5
6 Ledyard Avenue Cazenovia NY
Fully refundableReserve now, pay when you stay
The Brewster Inn
The Bond 1835

The Bond 1835

4 out of 5
2498 E Lake Rd Skaneateles NY
The Bond 1835
Comfort Inn & Suites Airport

Comfort Inn & Suites Airport

4 out of 5
6701 Buckley Rd North Syracuse NY
Comfort Inn & Suites Airport
See all 563 properties in Downtown Syracuse
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.