2026 4 Star Hotels in Downtown

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Featured Downtown 4 Star Hotels

The Abernathy of Clemson

The Abernathy of Clemson

4 out of 5
157 Old Greenville Hwy Clemson SC
Fully refundableReserve now, pay when you stay
The Abernathy of Clemson
The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson

4 out of 5
110 Sloan St Clemson SC
Fully refundableReserve now, pay when you stay
The Shepherd Hotel Downtown Clemson
Liberty Hall Bed and Breakfast

Liberty Hall Bed and Breakfast

4 out of 5
621 S Mechanic St Pendleton SC
Liberty Hall Bed and Breakfast
Designer Retreat w/ Pool, Golf + Beach Access!

Designer Retreat w/ Pool, Golf + Beach Access!

4 out of 5
Salem SC
Designer Retreat w/ Pool, Golf + Beach Access!
Wooded Keowee Key Retreat Near Golf & Trails

Wooded Keowee Key Retreat Near Golf & Trails

4 out of 5
Salem SC
Wooded Keowee Key Retreat Near Golf & Trails
Lake Keowee Condo: Resort Pools & Lake Access!

Lake Keowee Condo: Resort Pools & Lake Access!

4 out of 5
Salem SC
Lake Keowee Condo: Resort Pools & Lake Access!
Lake Hartwell Frank Howard Home Clemson

Lake Hartwell Frank Howard Home Clemson

4 out of 5
7008 SC-187 Anderson SC
Lake Hartwell Frank Howard Home Clemson
Keowee Key Condo w/ Lake Access & Community Pools!

Keowee Key Condo w/ Lake Access & Community Pools!

4 out of 5
Salem SC
Keowee Key Condo w/ Lake Access & Community Pools!
Salem Vacation Rental w/ Lake Keowee Access!

Salem Vacation Rental w/ Lake Keowee Access!

4 out of 5
Salem SC
Salem Vacation Rental w/ Lake Keowee Access!
See all 1,357 properties in Downtown
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.