2025 4 Star Hotels in City Center Medford

Choose two or more items and save on your trip:

Featured City Center Medford 4 Star Hotels

Compass by Margaritaville in Medford

Compass by Margaritaville in Medford

4 out of 5
2399 S Pacific Hwy, Medford, OR
Compass by Margaritaville in Medford
McCall House Boutique Inn

McCall House Boutique Inn

4 out of 5
153 Oak St, Ashland, OR
McCall House Boutique Inn
Hummingbird Estate Wine & Suites

Hummingbird Estate Wine & Suites

4.5 out of 5
1677 Old Stage Rd, Central Point, OR
Hummingbird Estate Wine & Suites
Country Willows Inn and Estate

Country Willows Inn and Estate

4 out of 5
1313 Clay St, Ashland, OR
Fully refundableReserve now, pay when you stay
Country Willows Inn and Estate
Paschal Winery

Paschal Winery

4.5 out of 5
1122 Suncrest Rd, Talent, OR
Paschal Winery
The Mountain Ave House by WanderLodges

The Mountain Ave House by WanderLodges

4 out of 5
78 N Mountain Ave, Ashland, OR
The Mountain Ave House by WanderLodges
Arden Forest Inn

Arden Forest Inn

4 out of 5
261 W Hersey St, Ashland, OR
Arden Forest Inn
Hanna's House by WanderLodges

Hanna's House by WanderLodges

4 out of 5
39 4th St, Ashland, OR
Hanna's House by WanderLodges
Barclay Klum House by WanderLodges

Barclay Klum House by WanderLodges

4 out of 5
1023 E Main St, Ashland, OR
Barclay Klum House by WanderLodges
See all 666 properties in City Center Medford
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.